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ACTIVE NOT RECRUITING

NCT00310180

PHASE3

Hormone Therapy With or Without Combination Chemotherapy in Treating Women Who Have Undergone Surgery for Node-Negative Breast Cancer (The TAILORx Trial)

Sponsor: National Cancer Institute (NCI)

View on ClinicalTrials.gov

Summary

This randomized phase III trial studies the best individual therapy for women who have node-negative, estrogen-receptor positive breast cancer by using a special test (Oncotype DX), and whether hormone therapy alone or hormone therapy together with combination chemotherapy is better for women who have an Oncotype DX recurrence score of 11-25. Estrogen can cause the growth of breast cancer cells. Hormone therapy may fight breast cancer by blocking the use of estrogen by the tumor cells or by lowering the amount of estrogen the body makes. Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving hormone therapy together with more than one chemotherapy drug (combination chemotherapy) has been shown to reduce the chance of breast cancer recurrence, but the benefit of adding chemotherapy to hormone therapy for women with node-negative, estrogen-receptor positive breast cancer is small. New tests may provide information about which patients are more likely to benefit from chemotherapy.

Official title: Program for the Assessment of Clinical Cancer Tests (PACCT-1): Trial Assigning Individualized Options for Treatment:The TAILORx Trial

Key Details

Gender

FEMALE

Age Range

18 Years - 75 Years

Study Type

INTERVENTIONAL

Enrollment

10273

Start Date

2006-04-07

Completion Date

2030-09-30

Last Updated

2026-10-01

Healthy Volunteers

Conditions

Breast Adenocarcinoma Hormone Receptor Positive Stage IA Breast Cancer AJCC v7 Stage IB Breast Cancer AJCC v7 Stage IIA Breast Cancer AJCC v6 and v7 Stage IIB Breast Cancer AJCC v6 and v7 Stage IIIB Breast Cancer AJCC v7

Interventions

DRUG

Anastrozole

Given PO

DRUG

Exemestane

Given PO

OTHER

Laboratory Biomarker Analysis

Correlative studies

DRUG

Letrozole

Given PO

OTHER

Quality-of-Life Assessment

Ancillary studies

RADIATION

Radiation Therapy

Undergo radiation therapy or partial breast irradiation

DRUG

Tamoxifen Citrate

Given PO

Inclusion Criteria: * Patients with operable histologically confirmed adenocarcinoma of the female breast who have completed primary surgical treatment and meet the following criteria: * ER and/or progesterone receptor (PR)-positive: Estrogen and/or progesterone receptor positive disease (as defined by local pathology laboratory) * Negative axillary nodes: As assessed by a sentinel lymph node biopsy, an axillary dissection, or both, and as defined by the Sixth Edition of the American Joint Committee on Cancer (AJCC) staging criteria * Tumor size 1.1-5.0 cm (or 5 mm-1.0 cm plus unfavorable histological features): * Unfavorable features defined as intermediate or poor nuclear and/or histologic grade, or lymphovascular invasion * NOTE: Definition of tumor size: The tumor size used for determination of eligibility is the pathologic tumor size, which is usually determined by the size of the tumor as measured by inspection of the gross specimen; if the tumor size is measured microscopically and the tumor includes ductal carcinoma in-situ, the measurement should include only the invasive component of the tumor * The tumor must be human epidermal growth factor receptor 2 (Her2)/neu negative by either fluorescent in-situ hybridization (FISH) or immunohistochemistry (e.g. 0 or 1+ by DAKO Herceptest) * The patient and physician must be agreeable to initiate standard chemotherapy and hormonal therapy as adjuvant therapy * A tissue specimen from the primary breast cancer has been located and is ready to be shipped to the appropriate laboratory after consent is obtained and within 3 days following pre-registration; NOTE: For determination of the Oncotype Recurrence Score, tissue must be shipped to Genomic Health; if the Oncotype DX Recurrence Score was previously performed by Genomic Health (prior to pre-registration), tissue must be submitted to the Eastern Cooperative Oncology Group (ECOG)-American College of Radiology Imaging Network (ACRIN) Central Biorepository and Pathology Facility upon randomization * Leukocyte count \>= 3500/mm\^3 * Platelets \>= 100,000/mm\^3 * Serum creatinine =\< 1.5 mg/dL * Serum aspartate transaminase (AST) that is =\< 3-fold the upper institutional limits of normal * Patients must be disease-free of prior invasive malignancies for \>= 5 years with the exception of curatively-treated basal cell or squamous cell carcinoma of the skin or carcinoma in situ of the cervix; patients with a previous ipsilateral or contralateral invasive breast cancer, or with bilateral synchronous cancers, are not eligible; patients with previous ipsilateral or contralateral ductal in situ carcinoma (DCIS) are not eligible * Prior treatment * Mandatory prior surgery criteria: * Patient must pre-register within 84 days from the final surgical procedure required to adequately treat the primary tumor (please note that if margins are not clear and a resection has to be conducted after pre-registration but before randomization, the patient will be deemed to be within the 84 day window allowed by protocol and therefore eligible) * All tumors should be removed by either a mastectomy or local excision plus an acceptable axillary procedure (i.e., sentinel lymph node biopsy, axillary dissection, or both); there must be adequate (at least 1 mm if margin width specified) tumor-free margins of resection (for invasive and ductal carcinoma in-situ) in order for the patients to be eligible; patients with lobular carcinoma in-situ involving the resection margins are eligible * Criteria re: other prior treatments: * No prior chemotherapy for this malignancy * No prior radiation therapy for this malignancy; this includes no prior MammoSite Brachytherapy radiation therapy (RT) * Hormonal therapy: Patients who develop breast cancer while receiving a selective estrogen-receptor modulator (SERM; e.g., tamoxifen, toremifene, raloxifene) or an aromatase inhibitor (e.g., anastrazole, letrozole, exemestane) for breast cancer prevention or a SERM for other indications (e.g., raloxifene for osteoporosis) are not eligible; however, patients may have received up to 8 weeks of a SERM or aromatase inhibitor for this malignancy and still be eligible for study entry * Patients must have an anticipated life expectancy of at least 10 years * Patients with the following medical conditions should not be enrolled on the study: * Chronic obstructive pulmonary disease requiring treatment * Chronic liver disease (e.g., cirrhosis, chronic active hepatitis) * Previous history of a cerebrovascular accident * History of congestive heart failure or other cardiac disease that would represent a contraindication to the use of an anthracycline (e.g., doxorubicin or epirubicin) * Chronic psychiatric condition or other condition that would impair compliance with the treatment regimen * Women must not be pregnant or breast-feeding; all females of childbearing potential must have a blood test or urine study within 2 weeks prior to pre-registration to rule out pregnancy * Women of childbearing potential must be strongly advised to utilize an accepted and effective form of non-hormonal contraception (e.g. intrauterine device, condoms, diaphragm, abstinence) * Patients must not have previously had the Oncotype DX Assay performed, with the exception of patients who have had the assay performed and have a recurrence score of 11-25

Locations (1222)

Northeast Alabama Regional Medical Center

Anniston, Alabama, United States

University of Alabama at Birmingham Cancer Center

Birmingham, Alabama, United States

Mobile Infirmary Medical Center

Mobile, Alabama, United States

Providence Hospital

Mobile, Alabama, United States

University of South Alabama Mitchell Cancer Institute

Mobile, Alabama, United States

Alaska Regional Hospital

Anchorage, Alaska, United States

Providence Alaska Medical Center

Anchorage, Alaska, United States

Fairbanks Memorial Hospital

Fairbanks, Alaska, United States

Banner Thunderbird Medical Center

Glendale, Arizona, United States

Banner Desert Medical Center

Mesa, Arizona, United States

Banner Baywood Medical Center

Mesa, Arizona, United States

Banner-University Medical Center Phoenix

Phoenix, Arizona, United States

Western Regional CCOP

Phoenix, Arizona, United States

Virginia G Piper Cancer Care-Del Camino

Scottsdale, Arizona, United States

Banner University Medical Center - Tucson

Tucson, Arizona, United States

Sparks Regional Medical Center

Fort Smith, Arkansas, United States

Mercy Hospital Fort Smith

Fort Smith, Arkansas, United States

CHI Saint Vincent Cancer Center Hot Springs

Hot Springs, Arkansas, United States

NEA Baptist Memorial Hospital

Jonesboro, Arkansas, United States

Saint Bernards Regional Medical Center

Jonesboro, Arkansas, United States

University of Arkansas for Medical Sciences

Little Rock, Arkansas, United States

Arroyo Grande Community

Arroyo Grande, California, United States

PCR Oncology

Arroyo Grande, California, United States

Alta Bates Summit Medical Center-Herrick Campus

Berkeley, California, United States

Providence Saint Joseph Medical Center/Disney Family Cancer Center

Burbank, California, United States

Mills-Peninsula Medical Center

Burlingame, California, United States

East Bay Radiation Oncology Center

Castro Valley, California, United States

Eden Hospital Medical Center

Castro Valley, California, United States

Valley Medical Oncology Consultants-Castro Valley

Castro Valley, California, United States

Enloe Medical Center

Chico, California, United States

Community Cancer Institute

Clovis, California, United States

John Muir Medical Center-Concord

Concord, California, United States

City of Hope Comprehensive Cancer Center

Duarte, California, United States

Bay Area Breast Surgeons Inc

Emeryville, California, United States

Kaiser Permanente-Fremont

Fremont, California, United States

Valley Medical Oncology Consultants-Fremont

Fremont, California, United States

Washington Health

Fremont, California, United States

California Cancer Associates for Research and Excellence (cCare)

Fresno, California, United States

Saint Jude Medical Center

Fullerton, California, United States

Glendale Memorial Hospital and Health Center

Glendale, California, United States

Marin Cancer Care Inc

Greenbrae, California, United States

Marin General Hospital

Greenbrae, California, United States

Saint Rose Hospital

Hayward, California, United States

Scripps Green Hospital

La Jolla, California, United States

UC San Diego Moores Cancer Center

La Jolla, California, United States

Loma Linda University Medical Center

Loma Linda, California, United States

Long Beach Memorial Medical Center-Todd Cancer Institute

Long Beach, California, United States

USC / Norris Comprehensive Cancer Center

Los Angeles, California, United States

UCLA / Jonsson Comprehensive Cancer Center

Los Angeles, California, United States

Contra Costa Regional Medical Center

Martinez, California, United States

Fremont - Rideout Cancer Center

Marysville, California, United States

Providence Holy Cross Medical Center

Mission Hills, California, United States

Memorial Medical Center

Modesto, California, United States

Community Hospital of Monterey Peninsula

Monterey, California, United States

Palo Alto Medical Foundation-Camino Division

Mountain View, California, United States

Northridge Hospital Medical Center

Northridge, California, United States

Sutter Cancer Research Consortium

Novato, California, United States

Wilma Chan Highland Hospital