Clinical Research Directory

Inclusion Criteria: * Medical screening. * Female and male subjects aged 8-16 years and 11 months, with clinical anorexia nervosa and / or reference to the diagnostic criteria of DSM-IV (1) before or at early puberty (Tanner stage 1 or 2) and with a prolonged Catch-Down for at least 18 months (HV ≤ 2 cm / year), with bone age ≤ 12 years in girls and ≤14 years in boys. * Anorexia nervosa diagnosed at least 1 year before the study * Growth velocity documented for at least 18 months before inclusion * As with any child with a severe Catch-Down an assessment of GH secretion must be performed before inclusion (in the context of care) in the trial, which is not conditioned by the GH peak value : GH value of \<20 miu / L will lead to the production of a brain MRI (in the context of care) that have to be normal (normal hypothalamic-pituitary axis and absence of tumor pathology) to allow Inclusion of the patient. * Normal glucose tolerance * Stable metabolic state with of weight gain of at least 10% of body weight from the time the body mass index was the lowest in relation to the occurrence of the disease and normal blood electrolytes (no hypokalemia) . * Subjects whose holders have signed parental consent * Subjects whose holders of parental authority are affiliated to a social security scheme * CMU (CMU universal medical coverage). Exclusion Criteria: * Subjects in the mid-puberty (Tanner stage 3 or 4) or with menarche. * Subjects with a chromosomal abnormality or other chronic disease associated chronic requiring long-term treatment. * Impaired glucose tolerance or diabetes. * Inability of the patient or the medical team to ensure the progress and monitoring under the protocol. * Participation in another trial. * Bradycardia ≤ 50 bpm. * Children whose holders of parental authority are not beneficiaries of social security * Contra-indication to SOMATROPINE