Clinical Research Directory

Inclusion Criteria: * Scheduled for elective posterolateral lumbar spine fusion with bilateral transpedicular screw instrumentation under general anaesthesia. * Written informed consent from the participating subject Exclusion Criteria: * A previous history of intolerance to the study drug or related compounds and additives * Concomitant drug therapy with oxycodone or buprenorphine. * History of ischemic heart disease or conduction disturbance * BMI \> 35 * Existing significant haematological, endocrine, metabolic or gastrointestinal disease * History of alcoholism, drug abuse, psychological or other emotional problems that are likely to invalidate informed consent * Allergy to dexmedetomidine or oxycodone * Blood loss exceeding 1500 ml during operation