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Study of Durvalumab With Tremelimumab Versus SoC as 1st Line Therapy in Metastatic Non Small-Cell Lung Cancer (NSCLC) (NEPTUNE)
Sponsor: AstraZeneca
Summary
This is a randomized, open-label, multi-center, global, Phase III study to determine the efficacy and safety of durvalumab + tremelimumab combination therapy versus platinum-based SoC chemotherapy in the first-line treatment of patients with epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) wild-type advanced or metastatic NSCLC.
Official title: A Phase III Randomized, Open-Label, Multi-Center, Global Study of MEDI4736 in Combination With Tremelimumab Therapy Versus Standard of Care Platinum-Based Chemotherapy in First-Line Treatment of Patients With Advanced or Metastatic Non Small-Cell Lung Cancer (NSCLC).
Key Details
Gender
All
Age Range
18 Years - 130 Years
Study Type
INTERVENTIONAL
Enrollment
953
Start Date
2015-11-03
Completion Date
2026-12-31
Last Updated
2026-08-06
Healthy Volunteers
No
Conditions
Interventions
Durvalumab +Tremelimumab
Paclitaxel + carboplatin
Chemotherapy Agents
Gemcitabine + cisplatin
Chemotherapy Agents
Gemcitabine + carboplatin
Chemotherapy Agents
Pemetrexed + cisplatin
Chemotherapy Agent
Pemetrexed + carboplatin
Chemotherapy Agent
Locations (210)
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Anaheim, California, United States
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San Diego, California, United States
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Santa Rosa, California, United States
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Louisville, Kentucky, United States
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Florham Park, New Jersey, United States
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Albuquerque, New Mexico, United States
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East Setauket, New York, United States
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Fresh Meadows, New York, United States
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Poughkeepsie, New York, United States
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Stony Brook, New York, United States
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Canton, Ohio, United States
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Columbus, Ohio, United States
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Zanesville, Ohio, United States
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Pittsburgh, Pennsylvania, United States
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Houston, Texas, United States
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Berazategui, Argentina
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CABA, Argentina
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Ciudad de Buenos Aires, Argentina
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Córdoba, Argentina
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La Rioja, Argentina
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Rosario, Argentina
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San Salvador de Jujuy, Argentina
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Santa Rosa, Argentina
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Barretos, Brazil
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Belo Horizonte, Brazil
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Belo Horizonte, Brazil
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Fortaleza, Brazil
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Ijuí, Brazil
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Itajaí, Brazil
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Porto Alegre, Brazil
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Porto Alegre, Brazil
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Porto Alegre, Brazil
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São José do Rio Preto, Brazil
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São Paulo, Brazil
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São Paulo, Brazil
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São Paulo, Brazil
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São Paulo, Brazil
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Plovdiv, Bulgaria
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Shumen, Bulgaria
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Sofia, Bulgaria
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Sofia, Bulgaria
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Sofia, Bulgaria
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Sofia, Bulgaria
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Varna, Bulgaria
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Vratsa, Bulgaria
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Santiago, Chile
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Santiago, Chile
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Santiago, Chile
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Santiago, Chile
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Santiago, Chile
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Temuco, Chile
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Viña del Mar, Chile
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Beijing, China
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Changchun, China
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Chongqing, China
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Guangzhou, China
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Hangzhou, China
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Shanghai, China
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Shanghai, China
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Ürümqi, China
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Wuhan, China
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Wuhan, China
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Odense C, Denmark
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Oulu, Finland
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Tampere, Finland
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Athens, Greece
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Athens, Greece
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Athens, Greece
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Heraklion, Greece
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Holargos, Athens, Greece
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Ioannina, Greece
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Hong Kong, Hong Kong
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King's Park, Hong Kong
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Shatin, Hong Kong
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Ahmedabad, India
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Bangalore, India
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Bangalore, India
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Chennai, India
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Gurgaon, India
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Karamsad, India
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New Delhi, India
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Beersheba, Israel
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Jerusalem, Israel
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Kfar Saba, Israel
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Nahariya, Israel
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Petah Tikva, Israel
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Ramat Gan, Israel
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Bunkyō City, Japan
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Fukushima, Japan
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Habikino-shi, Japan
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Hirosaki-shi, Japan
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Iizuka-shi, Japan
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Iwakuni-shi, Japan
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Kanazawa, Japan
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Kishiwada-shi, Japan
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Kobe, Japan
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Kurume-shi, Japan
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Kyoto, Japan
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Mitaka-shi, Japan
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Nagaoka-shi, Japan