Clinical Research Directory

Inclusion Criteria for Part 1 of the study: * Male and between 18-65 years of age. * Diagnosed with X-ALD based on genetic testing. * Clinical evidence of spinal cord involvement. Additional Inclusion Criteria for Part 2 of the study: \- Completion of the entire 96-week double-blind period of the study (Part 1). Exclusion Criteria for both parts of the study: * Any other chronic neurological disease with signs of spastic paraplegia, such as hereditary spastic paraplegia, multiple sclerosis, etc. * Presence of inflammatory (Gd-enhancing) MRI lesions or any abnormality other than those mentioned in the inclusion criteria. * Known type 1 or type 2 diabetes. * Known intolerance to pioglitazone or any other thiazolidinedione. * Taking or have taken honokiol, pioglitazone or other thiazolidinediones within the 6 months prior to screening. * Previous bone marrow transplantation. * Previous or current history of cancer (other than treated basal cell carcinoma). * Previous or current history of congestive heart failure.