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Duration of Dual Anti-Platelet Therapy (DUAL-ACS)
Sponsor: University of Edinburgh
Summary
Despite substantial evidence supporting the use of dual anti-platelet therapy in patients with acute coronary syndrome, there remains major uncertainty regarding the optimal duration of therapy. Recent evidence suggests that shorter durations of dual anti-platelet therapy are superior because the avoidance of atherothrombotic events is counterbalanced by the greater risks of excess major bleeding with apparent increases in all-cause mortality with longer durations. We here propose an international randomised controlled trial of 18,318 patients with type 1 myocardial infarction allocated to differing durations of dual anti-platelet therapy. We will use electronic health record linkage to track duration of therapy and clinical outcomes in a real-world, real-time, efficient and highly cost-effective trial. This has the potential to define treatment duration, settle a major outstanding international controversy, and influence modern cardiology practice across the world.
Official title: Duration of Dual Anti-Platelet Therapy in Acute Coronary Syndrome
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
5094
Start Date
2018-04-26
Completion Date
2023-02-04
Last Updated
2026-11-03
Healthy Volunteers
No
Interventions
3 months dual anti-platelet therapy
Patients with acute coronary syndrome will be randomised to 3 months dual anti-platelet therapy.
12 months dual anti-platelet therapy
Patients with acute coronary syndrome will be randomised to 12 months dual anti-platelet therapy.
Locations (49)
Auckland City Hospital
Auckland, New Zealand
Middlemore Hospital
Auckland, New Zealand
Christchurch Hospital
Christchurch, New Zealand
Rotorua Hospital
Rotorua, New Zealand
Tauranga Hospital
Tauranga, New Zealand
Aberdeen Royal Infirmary
Aberdeen, United Kingdom
University Hospital Monklands
Airdrie, United Kingdom
William Harvey Hospital
Ashford, United Kingdom
University Hospital
Ayr, United Kingdom
Blackpool Victoria Hospital
Blackpool, United Kingdom
Royal Bournemouth Hospital
Bournemouth, United Kingdom
Bradford Royal Infirmary
Bradford, United Kingdom
Bristol Heart Institute
Bristol, United Kingdom
Cumberland Infirmary and West Cumberland Hospital
Carlisle, United Kingdom
Northumbria Specialist Emergency Care Hospital
Cramlington, United Kingdom
Dorset County Hospital
Dorchester, United Kingdom
Dumfries and Galloway Royal Infirmary
Dumfries, United Kingdom
Ninewells Hospital
Dundee, United Kingdom
University Hospital Hairmyres
East Kilbride, United Kingdom
Western General Hospital
Edinburgh, United Kingdom
Edinburgh Royal Infirmary
Edinburgh, United Kingdom
Royal Devon and Exeter Hospital
Exeter, United Kingdom
Glasgow Royal Infirmary
Glasgow, United Kingdom
Queen Elizabeth University Hospital
Glasgow, United Kingdom
Golden Jubilee National Hospital
Glasgow, United Kingdom
Inverclyde Royal Hospital
Greenock, United Kingdom
Conquest Hospital
Hastings, United Kingdom
Wycombe Hospital
High Wycombe, United Kingdom
Raigmore Hospital
Inverness, United Kingdom
West Middlesex University Hospital
Isleworth, United Kingdom
University Hospital Crosshouse
Kilmarnock, United Kingdom
Victoria Hospital
Kirkcaldy, United Kingdom
Forth Valley Royal Hospial
Larbert, United Kingdom
St John's Hospital
Livingston, United Kingdom
Royal Free Hospital
London, United Kingdom
St Thomas' Hospital
London, United Kingdom
Macclesfield District General Hospital
Macclesfield, United Kingdom
Borders General Hospital
Melrose, United Kingdom
James Cook Hospital
Middlesbrough, United Kingdom
John Radcliffe Hospital
Oxford, United Kingdom
Royal Alexandra Hospital
Paisley, United Kingdom
Perth Royal Infirmary
Perth, United Kingdom
Royal Berkshire Hospital
Reading, United Kingdom
Northern General Hospital
Sheffield, United Kingdom
Southampton General Hospital
Southampton, United Kingdom
Torbay Hospital
Torquay, United Kingdom
Royal Albert Edward Infirmary
Wigan, United Kingdom
University Hospital
Wishaw, United Kingdom
Yeovil District Hospital
Yeovil, United Kingdom