Clinical Research Directory

Inclusion Criteria: * Age \>18 years * Willing to participate and able to understand, read and sign the informed consent document before the planned procedure * Eligible for coronary angiography and/or PCI * Coronary artery disease in one or more native major epicardial vessels or their branches by coronary angiogram with visually assessed de novo coronary stenosis in which the physiological severity of the lesion is in question (typically 40-90% diameter stenosis). * Stable angina or acute coronary syndrome (non-culprit vessels only and outside of primary intervention during acute STEMI or NSTE-ACS) Exclusion Criteria: * Previous CABG with patent grafts to the interrogated vessel * Tandem stenoses separated by more than 10 mm that require separate pressure guide wire interrogation or PCI (not to be interrogated or treated as a single stenosis) * Total coronary occlusions * Hemodynamic instability (Killip class III-IV) * Heavily calcified or tortuous vessels * Terminal disease with life expectancy of less than 12 months * STEMI within 24 hours of procedure * Severe valvular heart disease requiring intervention/surgery * ACS patients with difficulty in assessing the culprit lesion * Significant contraindication to adenosine administration (e.g. Asthma bronchiale) * Pregnancy