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A Study Comparing Risankizumab to Placebo in Participants With Active Psoriatic Arthritis Including Those Who Have a History of Inadequate Response or Intolerance to Biologic Therapy(Ies)
Sponsor: AbbVie
Summary
The purpose of this study is to evaluate the safety and efficacy of risankizumab in adults with moderately to severely active psoriatic arthritis (PsA).
Official title: A Phase 3, Randomized, Double-Blind Study Comparing Risankizumab to Placebo in Subjects With Active Psoriatic Arthritis Including Those Who Have a History of Inadequate Response or Intolerance to Biologic Therapy(Ies) (KEEPsAKE 2)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
444
Start Date
2019-03-07
Completion Date
2029-01
Last Updated
2026-10-28
Healthy Volunteers
No
Conditions
Interventions
Placebo
Placebo for risankizumab administered by subcutaneous (SC) injection
Risankizumab
Risankizumab administered by subcutaneous (SC) injection
Locations (138)
Pinnacle Research Group /ID# 167953
Anniston, Alabama, United States
St. Jude Heritage /ID# 166842
Fullerton, California, United States
Newport Huntington Medica /ID# 207423
Huntington Beach, California, United States
Arthritis & Osteo Medical Ctr /ID# 166541
La Palma, California, United States
East Bay Rheumatology Medical /ID# 166845
San Leandro, California, United States
Inland Rheum Clin Trials Inc. /ID# 166621
Upland, California, United States
Denver Arthritis Clinic /ID# 166442
Denver, Colorado, United States
New England Research Associates, LLC /ID# 166525
Bridgeport, Connecticut, United States
Yale University /ID# 166330
New Haven, Connecticut, United States
Arthritis & Rheumatic Disease Specialties /ID# 212582
Aventura, Florida, United States
SIMED Health, LLC /ID# 207457
Gainesville, Florida, United States
Sweet Hope Research Specialty Inc /ID# 168163
Hialeah, Florida, United States
Rheum Assoc of Central FL /ID# 201629
Orlando, Florida, United States
HMD Research LLC /ID# 208428
Orlando, Florida, United States
Millennium Research /ID# 201627
Ormond Beach, Florida, United States
Arthritis Center, Inc. /ID# 208116
Palm Harbor, Florida, United States
IRIS Research and Development, LLC /ID# 166351
Plantation, Florida, United States
BayCare Medical Group /ID# 201630
St. Petersburg, Florida, United States
West Broward Rheumatology Associates /ID# 201234
Tamarac, Florida, United States
University of South Florida /ID# 208467
Tampa, Florida, United States
ForCare Clinical Research /ID# 166375
Tampa, Florida, United States
Arthritis and Rheumatology /ID# 169438
Atlanta, Georgia, United States
Clinic of Robert Hozman/Clinical Investigation Specialists /ID# 166681
Skokie, Illinois, United States
Springfield Clinic /ID# 166345
Springfield, Illinois, United States
Ochsner Clinic Foundation /ID# 166622
Baton Rouge, Louisiana, United States
The Arthritis & Diabetes Clinic, Inc. /ID# 166707
Monroe, Louisiana, United States
MMP Women's Health /ID# 169334
Portland, Maine, United States
Klein and Associates MD /ID# 166549
Hagerstown, Maryland, United States
Duplicate_The Center for Rheumatology & Bone Research /ID# 166448
Wheaton, Maryland, United States
Clinical Pharmacology Study Gr /ID# 166455
Worcester, Massachusetts, United States
St. Paul Rheumatology /ID# 166599
Eagan, Minnesota, United States
Clinvest Research LLC /ID# 166745
Springfield, Missouri, United States
Clayton Medical Associates, P.C. dba Saint Louis Rheumatology /ID# 166389
St Louis, Missouri, United States
Glacier View Research Institute /ID# 169344
Kalispell, Montana, United States
Dartmouth-Hitchcock Medical Center /ID# 169443
Lebanon, New Hampshire, United States
Ocean Rheumatology, PA /ID# 166561
Toms River, New Jersey, United States
Arthritis Rheumatic and Back Disease Associates. P.A. /ID# 166658
Voorhees Township, New Jersey, United States
Paramount Medical Research Con /ID# 166334
Middleburg Heights, Ohio, United States
Health Research of Oklahoma /ID# 166408
Oklahoma City, Oklahoma, United States
Altoona Ctr Clinical Res /ID# 166691
Duncansville, Pennsylvania, United States
Clinical Research Ctr Reading /ID# 166354
Wyomissing, Pennsylvania, United States
West Tennessee Research Institute /ID# 166429
Jackson, Tennessee, United States
Nashville Arthritis and Rheumatology /ID# 208395
Nashville, Tennessee, United States
Amarillo Ctr for Clin Research /ID# 208340
Amarillo, Texas, United States
Tekton Research, Inc. /ID# 166493
Austin, Texas, United States
Precision Comprehensive Clinical Research Solutions /ID# 208156
Colleyville, Texas, United States
Rheumatology Clinic of Houston /ID# 166636
Houston, Texas, United States
West Texas Clinical Research /ID# 208155
Lubbock, Texas, United States
SW Rheumatology Res. LLC /ID# 166587
Mesquite, Texas, United States
Trinity Universal Research Associates, Inc /ID# 208387
Plano, Texas, United States
DM Clinical Research /ID# 208350
Tomball, Texas, United States
Kadlec Clinic Rheumatology /ID# 167667
Kennewick, Washington, United States
Arthritis Northwest, PLLC /ID# 169535
Spokane, Washington, United States
Rheumatology and Pulmonary Clinic /ID# 169341
Beckley, West Virginia, United States
Rheumatic Disease Center, LLP /ID# 166682
Glendale, Wisconsin, United States
Hospital General de Agudos J. M. Ramos Mejia /ID# 169152
Buenos Aires, Ciuadad Autonoma de Buenos Aires, Argentina
Hospital Italiano de Buenos Aires /ID# 208473
Ciudad Autonoma Buenos Aires, Ciuadad Autonoma de Buenos Aires, Argentina
DOM Centro de Reumatologia /ID# 208478
Ciudad Autonoma de Buenos Aire, Ciuadad Autonoma de Buenos Aires, Argentina
Centro de Enfermedades del Hígado y Aparato Digestivo /ID# 169151
Rosario, Santa Fe Province, Argentina
Instituto CAICI /ID# 169156
Rosario, Santa Fe Province, Argentina
Centro Medico Privado de Reumatologia /ID# 208342
San Miguel de Tucumán, Tucumán Province, Argentina
Cimer /Id# 169155
San Miguel de Tucumán, Argentina
The Canberra Hospital /ID# 207591
Garran, Australian Capital Territory, Australia
Rheumatology Research Unit Sunshine Coast /ID# 207191
Maroochydore, Queensland, Australia
Griffith University /ID# 207504
Southport, Queensland, Australia
Emeritus Research /ID# 207195
Camberwell, Victoria, Australia
Monash Medical Centre /ID# 208033
Clayton, Victoria, Australia
UZ Gent /ID# 210037
Ghent, Oost-Vlaanderen, Belgium
Universitair Ziekenhuis Leuven /ID# 208209
Leuven, Vlaams-Brabant, Belgium
ReumaClinic /ID# 208211
Genk, Belgium
ZNA - Jan Palfijn /ID# 208210
Merksem, Belgium
CIP - Centro Internacional de Pesquisa /ID# 169524
Goiânia, Goiás, Brazil
LMK Sevicos Medicos S/S /ID# 169541
Porto Alegre, Rio Grande do Sul, Brazil
Percuro Clinical Research, Ltd /ID# 169530
Victoria, British Columbia, Canada
CIADS Research Co Ltd /ID# 169526
Winnipeg, Manitoba, Canada
Dermatrials Research /ID# 208303
Hamilton, Ontario, Canada
K. Papp Clinical Research /ID# 169527
Waterloo, Ontario, Canada
Centre Rhumatologie de l'Est /ID# 208302
Rimouski, Quebec, Canada
Bispebjerg and Frederiksberg Hospital /ID# 168763
Frederiksberg, Capital Region, Denmark
Aarhus University Hospital /ID# 168762
Aarhus C, Central Jutland, Denmark
East Tallinn Central Hospital /ID# 208317
Tallinn, Harju, Estonia
MediTrials /ID# 207815
Tartu, Tartu, Estonia
North Estonia Medical Centre /ID# 208319
Tallinn, Estonia
Ite Pihlajanlinna Kuopio /ID# 208316
Kuopio, Finland
Turku University Hospital /ID# 208199
Turku, Finland
Duplicate_CHU Bordeaux-Hopital Pellegrin /ID# 211159
Bordeaux, France
CHRU Tours - Hopital Trousseau /ID# 209343
Chambray-lès-Tours, France
Rheumazentrum Ruhrgebiet /ID# 207212
Herne, North Rhine-Westphalia, Germany
Immanuel Krankenhaus Berlin /ID# 207214
Buch, Germany
Center of Innovative Diagnostics and Therapeutics (CIRI GmbH) /ID# 209494
Frankfurt, Germany
MVZ Rheumatologie und Autoimmunmedizin Hamburg GmbH /ID# 209493
Hamburg, Germany
University General Hospital of Heraklion PA.G.N.I /ID# 206930
Heraklion, Crete, Greece
Naval Hospital of Athens /ID# 206928
Athens, Greece
Olympion General Clinic SA /ID# 207047
Pátrai, Greece
CRU Hungary Egeszsegugyi és Szolgaltato Kft. /ID# 169248
Miskolc, Borsod-Abauj Zemplen county, Hungary
Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont /ID# 169237
Szeged, Csongrád megye, Hungary
Vital-Medicina Kft. /ID# 208123
Veszprém, Veszprém megye, Hungary
Betegapolo Irgalmasrend Budai Irgalmasrendi Korhaz /ID# 209054
Budapest, Hungary
Sheba Medical Center /ID# 207468
Ramat Gan, Tel Aviv, Israel
Barzilai Medical Center /ID# 207471
Ashkelon, Israel