Clinical Research Directory
Browse clinical research sites, groups, and studies.
A Study of Cabozantinib Compared With Placebo in Subjects With Radioiodine-refractory Differentiated Thyroid Cancer Who Have Progressed After Prior Vascular Endothelial Growth Factor Receptor (VEGFR) -Targeted Therapy
Sponsor: Exelixis
Summary
The objective of this study is to evaluate the effect of cabozantinib compared with placebo on progression free survival (PFS) and objective response rate (ORR) in subjects with Radioiodine-Refractory Differentiated Thyroid Cancer (DTC) who have progressed after prior vascular endothelial growth factor receptor (VEGFR)-Targeted therapy.
Official title: A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Cabozantinib (XL184) in Subjects With Radioiodine-Refractory Differentiated Thyroid Cancer Who Have Progressed After Prior Vascular Endothelial Growth Factor Receptor (VEGFR) -Targeted Therapy
Key Details
Gender
All
Age Range
16 Years - Any
Study Type
INTERVENTIONAL
Enrollment
187
Start Date
2018-10-05
Completion Date
2027-07-31
Last Updated
2026-10-20
Healthy Volunteers
No
Conditions
Interventions
Cabozantinib
Tablets containing 60-mg or 20-mg cabozantinib once daily orally.
Placebo
Tablets containing placebo equivalent of 60-mg or 20-mg cabozantinib once daily orally.
Locations (164)
Exelixis Clinical Site #2
Newport Beach, California, United States
Exelixis Clinical Site #98
Sacramento, California, United States
Exelixis Clinical Site #69
San Francisco, California, United States
Exelixis Clinical Site #10
Stanford, California, United States
Exelixis Clinical Site #3
Torrance, California, United States
Exelixis Clinical Site #9
Aurora, Colorado, United States
Exelixis Clinical Site #21
New Haven, Connecticut, United States
Exelixis Clinical Site #4
Washington D.C., District of Columbia, United States
Exelixis Clinical Site #94
Miami, Florida, United States
Exelixis Clinical Site #93
Orlando, Florida, United States
Exelixis Clinical Site #6
Tampa, Florida, United States
Exelixis Clinical Site #164
Chicago, Illinois, United States
Exelixis Clinical Site #54
Lexington, Kentucky, United States
Exelixis Clinical Site #153
Boston, Massachusetts, United States
Exelixis Clinical Site #80
Ann Arbor, Michigan, United States
Exelixis Clinical Site #78
Detroit, Michigan, United States
Exelixis Clinical Site #22
Detroit, Michigan, United States
Exelixis Clinical Site #63
Columbia, Missouri, United States
Exelixis Clinical Site #42
St Louis, Missouri, United States
Exelixis Clinical Site #11
Omaha, Nebraska, United States
Exelixis Clinical Site #118
Morristown, New Jersey, United States
Exelixis Clinical Site #76
Charlotte, North Carolina, United States
Exelixis Clinical Site #19
Durham, North Carolina, United States
Exelixis Clinical Site #7
Cincinnati, Ohio, United States
Exelixis Clinical Site #5
Bethlehem, Pennsylvania, United States
Exelixis Clinical Site #1
Philadelphia, Pennsylvania, United States
Exelixis Clinical Site #75
Pittsburgh, Pennsylvania, United States
Exelixis Clinical Site #134
Charleston, South Carolina, United States
Exelixis Clinical Site #68
Nashville, Tennessee, United States
Exelixis Clinical Site #8
Houston, Texas, United States
Exelixis Clinical Site #113
Seattle, Washington, United States
Exelixis Clinical Site #96
Pergamino, Buenos Aires, Argentina
Exelixis Clinical Site #97
Caba, Argentina
Exelixis Clinical Site #129
Córdoba, Argentina
Exelixis Clinical Site #17
St Leonards, New South Wales, Australia
Exelixis Clinical Site #25
Waratah, New South Wales, Australia
Exelixis Clinical Site #86
Bedford Park, South Australia, Australia
Exelixis Clinical Site #24
Melbourne, Victoria, Australia
Exelixis Clinical Site #12
Herston, Australia
Exelixis Clinical Site #62
Salzburg, Austria
Exelixis Clinical Site #119
Vienna, Austria
Exelixis Clinical Site #90
Anderlecht, Belgium
Exelixis Clinical Site #31
Brussels, Belgium
Exelixis Clinical Site #26
Edegem, Belgium
Exelixis Clinical Site #74
Edegem, Belgium
Exelixis Clinical Site #100
Ghent, Belgium
Exelixis Clinical Site #27
Namur, Belgium
Exelixis Clinical Site #35
Cascavel, Paraná, Brazil
Exelixis Clinical Site #39
Porto Alegre, Rio Grande do Sul, Brazil
Exelixis Clinical Site #140
Porto Alegre, Rio Grande do Sul, Brazil
Exelixis Clinical Site #38
Porto Alegre, Rio Grande do Sul, Brazil
Exelixis Clinical Site #116
Ribeirão Preto, São Paulo, Brazil
Exelixis Clinical Site #40
São José do Rio Preto, São Paulo, Brazil
Exelixis Clinical Site #92
Rio de Janeiro, Brazil
Exelixis Clinical Site #47
São Paulo, Brazil
Exelixis Clinical Site #20
Calgary, Alberta, Canada
Exelixis Clinical Site #18
Edmonton, Alberta, Canada
Exelixis Clinical Site #107
London, Ontario, Canada
Exelixis Clinical Site #83
Toronto, Ontario, Canada
Exelixis Clinical Site #145
Osijek, Croatia
Exelixis Clinical Site #137
Zagreb, Croatia
Exelixis Clinical Site #138
Zagreb, Croatia
Exelixis Clinical Site #105
Brno, Czechia
Exelixis Clinical Site #104
Olomouc, Czechia
Exelixis Clinical Site #32
Dijon, Bourgogne-Franche-Comté, France
Exelixis Clinical Site #67
Bordeaux, New Aquitaine, France
Exelixis Clinical Site #45
Angers, Pays de la Loire Region, France
Exelixis Clinical Site #72
Marseille, Provence-Alpes-Côte d'Azur Region, France
Exelixis Clinical Site #102
Besançon, France
Exelixis Clinical Site #91
Lyon, France
Exelixis Clinical Site #82
Nice, France
Exelixis Clinical Site #152
Paris, France
Exelixis Clinical Site #95
Strasbourg, France
Exelixis Clinical Site #44
Villejuif, Île-de-France Region, France
Exelixis Clinical Site #121
Tübingen, Baden-Wurttemberg, Germany
Exelixis Clinical Site #156
Würzburg, Bavaria, Germany
Exelixis Clinical Site #125
Marburg, Hesse, Germany
Exelixis Clinical Site #163
Hanover, Lower Saxony, Germany
Exelixis Clinical Site #151
Dresden, Saxony, Germany
Exelixis Clinical Site #124
Magdeburg, Saxony-Anhalt, Germany
Exelixis Clinical Site #155
Aachen, Germany
Exelixis Clinical Site #131
Bonn, Germany
Exelixis Clinical Site #154
Essen, Germany
Exelixis Clinical Site #160
Freiburg im Breisgau, Germany
Exelixis Clinical Site #159
Hamburg, Germany
Exelixis Clinical Site #139
München, Germany
Exelixis Clinical Site #28
Hong Kong, Hong Kong
Exelixis Clinical Site #46
Budapest, Hungary
Exelixis Clinical Site #37
Pécs, Hungary
Exelixis Clinical Site #43
Haifa, Israel
Exelixis Clinical Site #41
Jerusalem, Israel
Exelixis Clinical Site #58
Petah Tikva, Israel
Exelixis Clinical Site #109
Viagrande, Catania, Italy
Exelixis Clinical Site #135
Catania, CT, Italy
Exelixis Clinical Site #132
Meldola, Forlì - Cesena, Italy
Exelixis Clinical Site #144
Genova, GE, Italy
Exelixis Clinical Site #143
Rozzano, Milano, Italy
Exelixis Clinical Site #29
Pisa, PI, Italy
Exelixis Clinical Site #120
Torino, TO, Italy
Exelixis Clinical Site #103
Milan, Italy