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Durvalumab+ Gemcitabine/Cisplatin (Neoadjuvant Treatment) and Durvalumab (Adjuvant Treatment) in Patients With MIBC
Sponsor: AstraZeneca
Summary
A Global Study to Determine the Efficacy and Safety of Durvalumab in Combination with Gemcitabine+Cisplatin for Neoadjuvant Treatment and Durvalumab Alone for Adjuvant Treatment in Patients with Muscle-Invasive Bladder Cancer
Official title: A Phase III, Randomized, Open-Label, Multi-Center, Global Study to Determine the Efficacy and Safety of Durvalumab in Combination With Gemcitabine+Cisplatin for Neoadjuvant Treatment Followed by Durvalumab Alone for Adjuvant Treatment in Patients With Muscle-Invasive Bladder Cancer.
Key Details
Gender
All
Age Range
18 Years - 130 Years
Study Type
INTERVENTIONAL
Enrollment
1063
Start Date
2018-11-16
Completion Date
2027-11-08
Last Updated
2026-10-15
Healthy Volunteers
No
Conditions
Interventions
Durvalumab
Anti- PD-L1 Antibody
Cisplatin
Chemotherapy Agent
Gemcitabine
Chemotherapy agent
Locations (188)
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Birmingham, Alabama, United States
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Los Angeles, California, United States
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Palo Alto, California, United States
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New Haven, Connecticut, United States
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Chicago, Illinois, United States
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Geneva, Illinois, United States
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Iowa City, Iowa, United States
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Westwood, Kansas, United States
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Louisville, Kentucky, United States
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New Orleans, Louisiana, United States
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Towson, Maryland, United States
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Ann Arbor, Michigan, United States
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Detroit, Michigan, United States
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New York, New York, United States
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Rochester, New York, United States
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Bethlehem, Pennsylvania, United States
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Burlington, Vermont, United States
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Milwaukee, Wisconsin, United States
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Brisbane, Australia
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Elizabeth Vale, Australia
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Macquarie University, Australia
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Melbourne, Australia
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Murdoch, Australia
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South Brisbane, Australia
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Bruges, Belgium
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Charleroi, Belgium
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Kortrijk, Belgium
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Leuven, Belgium
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Liège, Belgium
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Roeselare, Belgium
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Barretos, Brazil
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Porto Alegre, Brazil
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Porto Alegre, Brazil
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Porto Alegre, Brazil
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Porto Alegre, Brazil
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Rio de Janeiro, Brazil
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Santa Maria, Brazil
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São José do Rio Preto, Brazil
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São Paulo, Brazil
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São Paulo, Brazil
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São Paulo, Brazil
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São Paulo, Brazil
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Edmonton, Alberta, Canada
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Vancouver, British Columbia, Canada
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London, Ontario, Canada
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Ottawa, Ontario, Canada
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Toronto, Ontario, Canada
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Montreal, Quebec, Canada
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Sherbrooke, Quebec, Canada
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Antofagasta, Chile
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Port Montt, Chile
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Santiago, Chile
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Temuco, Chile
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Temuco, Chile
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Viña del Mar, Chile
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Brno, Czechia
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Brno, Czechia
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Hradec Králové, Czechia
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Olomouc, Czechia
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Prague, Czechia
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Prague, Czechia
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Prague, Czechia
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Angers, France
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Dijon, France
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Grenoble, France
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Montpellier, France
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Nîmes, France
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Pierre-Bénite, France
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Poitiers, France
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Rouen, France
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Bergisch Gladbach, Germany
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Bonn, Germany
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Cologne, Germany
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Erlangen, Germany
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Göttingen, Germany
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Herne, Germany
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Jena, Germany
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Magdeburg, Germany
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Mannheim, Germany
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Münster, Germany
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Nuremberg, Germany
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Oldenburg, Germany
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Regensburg, Germany
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Ulm, Germany
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Würzburg, Germany
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Haifa, Israel
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Jerusalem, Israel
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Kfar Saba, Israel
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Petah Tikva, Israel
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Ramat Gan, Israel
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Bari, Italy
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Bologna, Italy
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Florence, Italy
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Milan, Italy
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Milan, Italy
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Naples, Italy
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Orbassano, Italy
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Pozzuoli, Italy
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Verona, Italy
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Bunkyō City, Japan