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Durvalumab Treatment in Combination With Chemotherapy and Bevacizumab, Followed by Maintenance Durvalumab, Bevacizumab and Olaparib Treatment in Advanced Ovarian Cancer Patients
Sponsor: AstraZeneca
Summary
This is a Phase III randomised, double-blind, multi-centre study to evaluate the efficacy and safety of durvalumab in combination with standard of care platinum based chemotherapy and bevacizumab followed by maintenance durvalumab and bevacizumab or durvalumab, bevacizumab and olaparib in patients with newly diagnosed advanced ovarian cancer.
Official title: A Phase III Randomised, Double-Blind, Placebo-Controlled, Multicentre Study of Durvalumab in Combination With Chemotherapy and Bevacizumab, Followed by Maintenance Durvalumab, Bevacizumab and Olaparib in Newly Diagnosed Advanced Ovarian Cancer Patients (DUO-O).
Key Details
Gender
FEMALE
Age Range
18 Years - 130 Years
Study Type
INTERVENTIONAL
Enrollment
1407
Start Date
2019-01-04
Completion Date
2026-12-23
Last Updated
2026-07-07
Healthy Volunteers
No
Conditions
Interventions
Bevacizumab
Bevacizumab by intravenous infusion. In tBRCAm cohort bevacizumab is optional according to local practice.
Durvalumab
Durvalumab by intravenous infusion
Olaparib
Olaparib tablets
Placebo olaparib
Placebo tablets to match olaparib
Durvalumab placebo
Matching placebo for intravenous infusion
Carboplatin+Paclitaxel
Standard of care chemotherapy
Locations (214)
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Foothill Ranch, California, United States
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Los Angeles, California, United States
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Orange, California, United States
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San Francisco, California, United States
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Tampa, Florida, United States
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Augusta, Georgia, United States
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Hinsdale, Illinois, United States
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Indianapolis, Indiana, United States
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Towson, Maryland, United States
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Detroit, Michigan, United States
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Springfield, Missouri, United States
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Middletown, New Jersey, United States
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Montvale, New Jersey, United States
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Albany, New York, United States
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New York, New York, United States
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Uniondale, New York, United States
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Durham, North Carolina, United States
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Cleveland, Ohio, United States
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Dayton, Ohio, United States
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Hilliard, Ohio, United States
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Tulsa, Oklahoma, United States
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Lancaster, Pennsylvania, United States
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Philadelphia, Pennsylvania, United States
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Philadelphia, Pennsylvania, United States
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Pittsburgh, Pennsylvania, United States
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Salt Lake City, Utah, United States
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Graz, Austria
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Innsbruck, Austria
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Linz, Austria
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Vienna, Austria
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Aalst, Belgium
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Leuven, Belgium
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Namur, Belgium
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Ostend, Belgium
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Sint-Niklaas, Belgium
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Barretos, Brazil
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Florianópolis, Brazil
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Fortaleza, Brazil
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Londrina, Brazil
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Porto Alegre, Brazil
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Porto Alegre, Brazil
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Rio de Janeiro, Brazil
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São Paulo, Brazil
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São Paulo, Brazil
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Burgas, Bulgaria
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Plovdiv, Bulgaria
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Sofia, Bulgaria
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Varna, Bulgaria
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Calgary, Alberta, Canada
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Barrie, Ontario, Canada
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Greater Sudbury, Ontario, Canada
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Toronto, Ontario, Canada
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Montreal, Quebec, Canada
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Montreal, Quebec, Canada
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Montreal, Quebec, Canada
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Québec, Quebec, Canada
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Rimouski, Quebec, Canada
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Beijing, China
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Beijing, China
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Bengbu, China
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Changchun, China
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Changsha, China
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Changsha, China
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Chengdu, China
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Chongqing, China
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Dalian, China
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Guangzhou, China
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Guangzhou, China
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Hangzhou, China
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Hangzhou, China
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Harbin, China
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Hefei, China
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Jinhua, China
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Kunming, China
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Lanzhou, China
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Luzhou, China
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Nanchong, China
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Nanjing, China
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Nanning, China
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Nantong, China
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Shanghai, China
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Shanghai, China
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Wuhan, China
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Wuhan, China
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Xi'an, China
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Zhengzhou, China
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Zhengzhou, China
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Zhuhai, China
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Aalborg, Denmark
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Aarhus N, Denmark
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Odense, Denmark
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Roskilde, Denmark
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Vejle, Denmark
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Kuopio, Finland
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Oulu, Finland
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Turku, Finland
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Besançon, France
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Bordeaux, France
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Limoges, France
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Lyon, France