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Phase 1/2 Study of MRTX849 in Patients With Cancer Having a KRAS G12C Mutation KRYSTAL-1
Sponsor: Mirati Therapeutics Inc.
Summary
This study will evaluate the safety, tolerability, drug levels, molecular effects, and clinical activity of MRTX849 (adagrasib) in patients with advanced solid tumors that have a KRAS G12C mutation.
Official title: A Phase 1/2 Multiple Expansion Cohort Trial of MRTX849 in Patients With Advanced Solid Tumors With KRAS G12C Mutation KRYSTAL-1
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
731
Start Date
2019-01-15
Completion Date
2026-12-31
Last Updated
2026-07-29
Healthy Volunteers
No
Interventions
MRTX849
MRTX849 will be administered orally once or twice daily in a continuous regimen
Pembrolizumab
Pembrolizumab is administered as an intravenous infusion once every 3 weeks
Cetuximab
Cetuximab will be administered as an intravenous infusion once per week or once every 2 weeks
Afatinib
Afatinib will be administered orally once a day in a continuous regimen
Locations (222)
Local Institution - 001-826
Birmingham, Alabama, United States
Local Institution - 001-965
Anchorage, Alaska, United States
Local Institution - 001-821
Phoenix, Arizona, United States
Local Institution - 001-873-A
Tucson, Arizona, United States
Local Institution - 001-873
Tucson, Arizona, United States
Local Institution - 001-840-B
Bellflower, California, United States
Local Institution - 001-834
Beverly Hills, California, United States
Local Institution - 001-843
Duarte, California, United States
Local Institution - 001-850-K
Dublin, California, United States
Local Institution - 001-851
Fullerton, California, United States
Local Institution - 001-840-C
Harbor City, California, United States
Local Institution - 001-805
La Jolla, California, United States
Local Institution - 001-779
Los Alamitos, California, United States
Local Institution - 001-840
Los Angeles, California, United States
Local Institution - 001-578
Los Angeles, California, United States
Local Institution - 001-847
Newport Beach, California, United States
Local Institution - 001-850-B
Oakland, California, United States
Local Institution - 001-803
Orange, California, United States
Local Institution - 001-850-C
Roseville, California, United States
Local Institution - 001-850-J
Sacramento, California, United States
Local Institution - 001-850-D
Sacramento, California, United States
Local Institution - 001-845
San Diego, California, United States
Local Institution - 001-840-A
San Diego, California, United States
Local Institution - 001-850-H
San Francisco, California, United States
Local Institution - 001-850-E
San Francisco, California, United States
Local Institution - 001-850-F
San Jose, California, United States
Local Institution - 001-850-A
San Leandro, California, United States
Local Institution - 001-884
Santa Barbara, California, United States
Local Institution - 001-850-I
Santa Clara, California, United States
Local Institution - 001-884-A
Solvang, California, United States
Local Institution - 001-850
Vallejo, California, United States
Local Institution - 001-850-G
Walnut Creek, California, United States
Local Institution - 001-872
Aurora, Colorado, United States
Local Institution - 001-810
Aurora, Colorado, United States
Local Institution - 001-872-H
Boulder, Colorado, United States
Local Institution - 001-872-E
Colorado Springs, Colorado, United States
Local Institution - 001-872-L
Colorado Springs, Colorado, United States
Local Institution - 001-872-B
Denver, Colorado, United States
Local Institution - 001-951 - A
Denver, Colorado, United States
Local Institution - 001-951 - B
Denver, Colorado, United States
Local Institution - 001-846
Grand Junction, Colorado, United States
Local Institution - 001-951
Lafayette, Colorado, United States
Local Institution - 001-872-A
Lakewood, Colorado, United States
Local Institution - 001-872-D
Littleton, Colorado, United States
Local Institution - 001-872-K
Lone Tree, Colorado, United States
Local Institution - 001-872-C
Longmont, Colorado, United States
Local Institution - 001-872-J
Parker, Colorado, United States
Local Institution - 001-872-F
Pueblo, Colorado, United States
Local Institution - 001-872-G
Pueblo, Colorado, United States
Local Institution - 001-872-I
Thornton, Colorado, United States
Local Institution - 001-816
New Haven, Connecticut, United States
Local Institution - 001-871
Newark, Delaware, United States
Local Institution - 001-929i
Altamonte Springs, Florida, United States
Local Institution - 001-839
Boca Raton, Florida, United States
Local Institution - 001-922A
Bonita Springs, Florida, United States
Local Institution - 001-922D
Bradenton, Florida, United States
Local Institution - 001-929c
Brandon, Florida, United States
Local Institution - 001-922E
Cape Coral, Florida, United States
Local Institution - 001-929g
Clearwater, Florida, United States
Local Institution - 001-926b
Daytona Beach, Florida, United States
Local Institution - 001-922
Fort Myers, Florida, United States
Local Institution - 001-922B
Fort Myers, Florida, United States
Local Institution - 001-922C
Fort Myers, Florida, United States
Local Institution - 001-929b
Gainesville, Florida, United States
Local Institution - 001-829
Jacksonville, Florida, United States
Local Institution - 001-929m
Lady Lake, Florida, United States
Local Institution - 001-929e
Largo, Florida, United States
Local Institution - 001-929n
Lecanto, Florida, United States
Local Institution - 001-870
Miami, Florida, United States
Local Institution - 001-825
Miami Beach, Florida, United States
Local Institution - 001-922F
Naples, Florida, United States
Local Institution - 001-922G
Naples, Florida, United States
Local Institution - 001-538
Ocala, Florida, United States
Local Institution - 001-929p
Ocala, Florida, United States
Local Institution - 001-914
Orange City, Florida, United States
Local Institution - 001-929j
Orange City, Florida, United States
Local Institution - 001-929l
Orlando, Florida, United States
Local Institution - 001-877
Pensacola, Florida, United States
Local Institution - 001-922H
Port Charlotte, Florida, United States
Local Institution - 001-922I
Sarasota, Florida, United States
Local Institution - 001-922J
Sarasota, Florida, United States
Local Institution - 001-929h
Spring Hill, Florida, United States
Local Institution - 001-929a
St. Petersburg, Florida, United States
Local Institution - 001-929
St. Petersburg, Florida, United States
Local Institution - 001-926d
Stuart, Florida, United States
Local Institution - 001-929d
Tampa, Florida, United States
Local Institution - 001-929k
Tavares, Florida, United States
Local Institution - 001-929f
Trinity, Florida, United States
Local Institution - 001-922K
Venice, Florida, United States
Local Institution - 001-922L
Venice, Florida, United States
Local Institution - 001-926c
Vero Beach, Florida, United States
Local Institution - 001-926a
Wellington, Florida, United States
Local Institution - 001-926
West Palm Beach, Florida, United States
Local Institution - 001-929o
Winter Park, Florida, United States
Local Institution - 001-967
Athens, Georgia, United States
Local Institution - 001-835-C
Austell, Georgia, United States
Local Institution - 001-835-E
Austell, Georgia, United States
Local Institution - 001-835-D
Carrollton, Georgia, United States
Local Institution - 001-835-F
Carrollton, Georgia, United States
Local Institution - 001-835-A
Cartersville, Georgia, United States