Clinical Research Directory
Browse clinical research sites, groups, and studies.
A Phase 3 Study to Evaluate the Efficacy and Safety of MGL-3196 (Resmetirom) in Patients With NASH and Fibrosis
Sponsor: Madrigal Pharmaceuticals, Inc.
Summary
A double-blind placebo controlled randomized Phase 3 study to determine if 80 or 100 mg of MGL-3196 as compared with placebo resolves NASH and/or reduces fibrosis on liver biopsy and prevents progression to cirrhosis and/or advanced liver disease
Official title: A Phase 3, Multinational, Double-Blind, Randomized, Placebo-Controlled Study of MGL-3196 (Resmetirom) in Patients With Non-Alcoholic Steatohepatitis (NASH) and Fibrosis to Resolve NASH and Reduce Progression to Cirrhosis and/or Hepatic Decompensation
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
1759
Start Date
2019-03-28
Completion Date
2028-01
Last Updated
2026-06-01
Healthy Volunteers
No
Conditions
Interventions
MGL-3196
Tablet
Placebo
Matching Tablets
Liver Biopsy
A procedure in which a needle is inserted into the liver to collect a tissue sample
Locations (247)
University of Alabama at Birmingham
Birmingham, Alabama, United States
East Valley Family Physicians
Chandler, Arizona, United States
The Institute for Liver Health - Chandler
Chandler, Arizona, United States
The Institute for Liver Health - Glendale
Glendale, Arizona, United States
Desert Clinical Research
Mesa, Arizona, United States
Adobe Gastroenterology
Tucson, Arizona, United States
The Institute for Liver Health - Tucson
Tucson, Arizona, United States
Arkansas Gastroenterology
North Little Rock, Arkansas, United States
Fresno Clinical Research Center
Fresno, California, United States
National Research Institute - Huntington Park
Huntington Park, California, United States
University of California San Diego
La Jolla, California, United States
Cedars-Sinai Medical Center
Los Angeles, California, United States
National Research Institute - Los Angeles
Los Angeles, California, United States
Ruane Clinical Research
Los Angeles, California, United States
Stanford University School of Medicine
Palo Alto, California, United States
National Research Institute - Panorama City
Panorama City, California, United States
Alliance Clinical Research
Poway, California, United States
San Fernando Valley Health Institute
Van Nuys, California, United States
Colorado Springs Family Practice
Colorado Springs, Colorado, United States
South Denver Gastroenterology - Swedish Medical Center Office
Englewood, Colorado, United States
Excel Medical Clinical Trials
Boca Raton, Florida, United States
Covenant Metabolic Specialists - Fort Myers
Fort Myers, Florida, United States
University of Florida Hepatology Research at CTRB
Gainesville, Florida, United States
Nature Coast Clinical Research
Inverness, Florida, United States
Florida Research Institute
Lakewood Rch, Florida, United States
University of Miami
Miami, Florida, United States
Miami Dade Medical Research Institute
Miami, Florida, United States
Bioclinica Research - Orlando
Orlando, Florida, United States
Progressive Medical Research
Port Orange, Florida, United States
Covenant Research
Sarasota, Florida, United States
Bioclinica Research - The Villages
The Villages, Florida, United States
GI Specialists of Georgia
Marietta, Georgia, United States
Clinical Research - Chicago
Chicago, Illinois, United States
Northwestern Medical Faculty Foundation
Chicago, Illinois, United States
The University of Chicago Medicine
Chicago, Illinois, United States
University of Kansas Medical Center Research Institute
Fairway, Kansas, United States
Kansas Medical Clinic - Gastroenterology
Topeka, Kansas, United States
Texas Digestive Disease Consultants - Gastroenterology Associates - Baton Rouge
Baton Rouge, Louisiana, United States
Tandem Clinical Research
Marrero, Louisiana, United States
Tulane University School of Medicine
New Orleans, Louisiana, United States
Ochsner Medical Center
New Orleans, Louisiana, United States
Clinical Trials of America
West Monroe, Louisiana, United States
Walter Reed National Military Medical Center
Bethesda, Maryland, United States
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States
Gastrointestinal Associates and Endoscopy Center - Madison
Flowood, Mississippi, United States
Southern Therapy and Advanced Research
Jackson, Mississippi, United States
Saint Luke's Hospital of Kansas City
Kansas City, Missouri, United States
St. Luke's Hospital Of Kansas City
Kansas City, Missouri, United States
Kansas City Research Institute
Kansas City, Missouri, United States
Saint Louis University
St Louis, Missouri, United States
Clinical Research US - Henderson
Henderson, Nevada, United States
Mt. Sinai Medical Center
New York, New York, United States
New York Presbyterian Hospital
New York, New York, United States
University of North Carolina Medical Center - Chapel Hill
Charlotte, North Carolina, United States
Duke University Medical Center
Durham, North Carolina, United States
Cumberland Research Associates
Fayetteville, North Carolina, United States
Lucas Research
Morehead City, North Carolina, United States
Consultants for Clinical Research
Cincinnati, Ohio, United States
Aventiv Research - Columbus
Columbus, Ohio, United States
Awasty Research Network
Marion, Ohio, United States
Premier Medical Group - Clarksville
Clarksville, Tennessee, United States
Gastro One - Germantown - Centre Oak Way
Germantown, Tennessee, United States
Associates in Gastroenterology
Hermitage, Tennessee, United States
Gastrointestinal Associates - Knoxville
Knoxville, Tennessee, United States
South Texas Research Institute - Brownsville
Brownsville, Texas, United States
Dallas Research Center
Dallas, Texas, United States
Liver Center of Texas
Dallas, Texas, United States
Texas Digestive Disease Consultants - Dallas
Dallas, Texas, United States
The Liver Institute at Methodist Dallas Medical Center
Dallas, Texas, United States
South Texas Research Institute
Edinburg, Texas, United States
Brooke Army Medical Center
Fort Sam Houston, Texas, United States
Texas Digestive Disease Consultants - Fort Worth
Fort Worth, Texas, United States
Liver Associates of Texas
Houston, Texas, United States
Doctor's Hospital at Renaissance
McAllen, Texas, United States
Plano Research Center
Plano, Texas, United States
Pinnacle Clinical Research - Austin
Rollingwood, Texas, United States
Pinnacle Clinical Research
San Antonio, Texas, United States
San Antonio Research Center
San Antonio, Texas, United States
The Texas Liver Institute
San Antonio, Texas, United States
Texas Digestive Disease Consultants - San Marcos
San Marcos, Texas, United States
Impact Research Institute
Waco, Texas, United States
Texas Digestive Disease Consultants - Bay Area Gastroenterology
Webster, Texas, United States
Wasatch Peak Family Practice
Layton, Utah, United States
Salt Lake City Research Center
Murray, Utah, United States
University of Utah Hospital
Salt Lake City, Utah, United States
University of Virginia Health System
Charlottesville, Virginia, United States
Bon Secours St. Mary's Hospital of Richmond
Richmond, Virginia, United States
Hunter Holmes McGuire Veterans Administration Medical Center
Richmond, Virginia, United States
Virginia Commonwealth University
Richmond, Virginia, United States
Liver Institute Northwest
Seattle, Washington, United States
Royal Prince Alfred Hospital
Camperdown, New South Wales, Australia
Saint Vincent's Hospital Sydney
Darlinghurst, New South Wales, Australia
Nepean Hospital
Kingswood, New South Wales, Australia
John Hunter Hospital
New Lambton, New South Wales, Australia
Westmead Hospital
Westmead, New South Wales, Australia
Royal Brisbane and Women's Hospital
Herston, Queensland, Australia
Mater Misericordiae
South Brisbane, Queensland, Australia
Royal Adelaide Hospital
Adelaide, South Australia, Australia
Monash Medical Centre
Clayton, Victoria, Australia
Austin Health
Heidelberg, Victoria, Australia