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NCT03906071

PHASE3

Phase 3 Study of Sitravatinib Plus Nivolumab vs Docetaxel in Patients With Advanced Non-Squamous Non-Small Cell Lung Cancer

Sponsor: Mirati Therapeutics Inc.

View on ClinicalTrials.gov

Summary

This study will compare the efficacy of the investigational agent sitravatinib in combination with nivolumab versus docetaxel in patients with advanced non-squamous NSCLC who have previously experienced disease progression on or after platinum-based chemotherapy and checkpoint inhibitor therapy.

Official title: A Randomized Phase 3 Study of Sitravatinib in Combination With Nivolumab Versus Docetaxel in Patients With Advanced Non-Squamous Non-Small Cell Lung Cancer With Disease Progression On or After Platinum-Based Chemotherapy and Checkpoint Inhibitor Therapy SAPPHIRE

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

577

Start Date

2019-07-15

Completion Date

2025-09-30

Last Updated

2026-09-30

Healthy Volunteers

Conditions

Metastatic Non-Squamous Non-Small Cell Lung Cancer

Interventions

BIOLOGICAL

Nivolumab

Nivolumab is an antibody directed at the programmed death receptor-1 (PD-1), blocking its interaction with PD-L1 and PD-L2.

DRUG

Sitravatinib

Sitravatinib is a small molecule inhibitor of receptor tyrosine kinases.

DRUG

Docetaxel

Docetaxel is an anti-neoplastic agent that acts by disrupting the microtubular network in cells.

Locations (261)

Local Institution - 005-164

Birmingham, Alabama, United States

Clearview Cancer Institute - Huntsville

Huntsville, Alabama, United States

Palo Verde Cancer Specialists - Glendale

Glendale, Arizona, United States

The Oncology Institute of Hope & Innovation - Tucson

Tucson, Arizona, United States

Yuma Regional Medical Center

Yuma, Arizona, United States

Local Institution - 005-174

Jonesboro, Arkansas, United States

NEA Baptist Fowler Family Center for Cancer Care

Jonesboro, Arkansas, United States

Highlands Oncology Group - Springdale

Springdale, Arkansas, United States

Comprehensive Blood and Cancer Center - Bakersfield

Bakersfield, California, United States

Local Institution - 005-118

Beverly Hills, California, United States

Local Institution - 005-171

Fresno, California, United States

Providence Medical Foundation - Virginia K. Crosson Cancer Center - Fullerton

Fullerton, California, United States

Local Institution - 005-096

Long Beach, California, United States

Cancer and Blood Specialty Clinic

Los Alamitos, California, United States

Los Angeles Hematology Oncology Medical Group

Los Angeles, California, United States

Local Institution - 005-185

Los Angeles, California, United States

Local Institution - 005-072

Newport Beach, California, United States

Local Institution - 005-109

Northridge, California, United States

Local Institution - 005-177

Redlands, California, United States

Local Institution - 005-112

Riverside, California, United States

University of California San Francisco

San Francisco, California, United States

Local Institution - 005-176

San Marcos, California, United States

Local Institution - 005-192

Torrance, California, United States

Local Institution - 005-090

West Covina, California, United States

Local Institution - 005-105

Whittier, California, United States

Local Institution - 005-097

Lafayette, Colorado, United States

Eastern Connecticut Hematology and Oncology Associates

Norwich, Connecticut, United States

Michael and Dianne Bienes Comprehensive Cancer Center

Fort Lauderdale, Florida, United States

Local Institution - 005-120

Fort Myers, Florida, United States

Memorial Regional Hospital

Hollywood, Florida, United States

Watson Clinic Cancer and Research Center

Lakeland, Florida, United States

Mount Sinai Health System

Miami Beach, Florida, United States

Local Institution - 005-120E

Naples, Florida, United States

Local Institution - 005-079

Ocala, Florida, United States

Local Institution - 005-104

Orlando, Florida, United States

SCRI - Florida Cancer Specialists - North Region Research Office

St. Petersburg, Florida, United States

SCRI - Florida Cancer Specialists - Panhandle Research Office

Tallahassee, Florida, United States

Local Institution - 005-154

West Palm Beach, Florida, United States

University Cancer & Blood Center (UCBC) - Athens

Athens, Georgia, United States

Local Institution - 005-146

Atlanta, Georgia, United States

John B. Amos Cancer Center Research

Columbus, Georgia, United States

Local Institution - 005-119

Marietta, Georgia, United States

Straub Medical Center

Honolulu, Hawaii, United States

Local Institution - 005-191

Coeur d'Alene, Idaho, United States

Local Institution - 005-151

Chicago, Illinois, United States

Local Institution - 005-110

Evanston, Illinois, United States

Local Institution - 005-198

Niles, Illinois, United States

Orchard Healthcare Research

Skokie, Illinois, United States

Healthcare Research Network - Tinley Park

Tinley Park, Illinois, United States

Fort Wayne Medical Oncology and Hematology - Fort Wayne South Office

Fort Wayne, Indiana, United States

Local Institution - 005-122

Goshen, Indiana, United States

Franciscan Health Cancer Center Indianapolis

Indianapolis, Indiana, United States

Local Institution - 005-150

Lafayette, Indiana, United States

Local Institution - 005-169

Westwood, Kansas, United States

Local Institution - 005-098

Wichita, Kansas, United States

Commonwealth Cancer Center - Frankfort

Danville, Kentucky, United States

Local Institution - 005-153

Louisville, Kentucky, United States

New England Cancer Specialists - Scarborough

Scarborough, Maine, United States

Local Institution - 005-178

Rockville, Maryland, United States

Barbara Ann Karmanos Cancer Institute

Detroit, Michigan, United States

Henry Ford Hospital

Detroit, Michigan, United States

Local Institution - 005-127

Minneapolis, Minnesota, United States

Local Institution - 005-159

Saint Louis Park, Minnesota, United States

Jackson Oncology Associates - The Hederman Cancer Center

Jackson, Mississippi, United States

Central Care Cancer Center - Bolivar

Bolivar, Missouri, United States

Kansas City Care Health Center - Research Medical Campus

Kansas City, Missouri, United States

Sisters of Charity of Leavenworth Health St. Marys

Billings, Montana, United States

Saint Francis Cancer Treatment Center

Grand Island, Nebraska, United States

Methodist Hospital - Omaha

Omaha, Nebraska, United States

The Oncology Institute of Hope & Innovation - Henderson

Henderson, Nevada, United States

Local Institution - 005-152

Henderson, Nevada, United States

Local Institution - 005-142

Florham Park, New Jersey, United States

Local Institution - 005-163

Little Silver, New Jersey, United States

Cooperman Barnabas Medical Center

Livingston, New Jersey, United States

Regional Cancer Care Associates - Sparta

Sparta, New Jersey, United States

Local Institution - 005-123

Johnson City, New York, United States

Local Institution - 005-182

Lake Success, New York, United States

New York Cancer & Blood Specialists - Port Jefferson Medical Oncology

Port Jefferson Station, New York, United States

Local Institution - 005-107

Stony Brook, New York, United States

Local Institution - 005-196

Canton, Ohio, United States

USOR - Oncology Hematology Care - Blue Ash

Cincinnati, Ohio, United States

Local Institution - 005-181

Columbus, Ohio, United States

Tricounty Hematology and Oncology - Massillon

Massillon, Ohio, United States

Local Institution - 005-103

Toledo, Ohio, United States

Local Institution - 005-088

Oklahoma City, Oklahoma, United States

Providence Portland Medical Center

Portland, Oregon, United States

Local Institution - 005-073

Portland, Oregon, United States

USOR - Alliance Cancer Specialists - Horsham (Abington Hematology Oncology Associates)

Horsham, Pennsylvania, United States

Local Institution - 005-186

Philadelphia, Pennsylvania, United States

Local Institution - 005-137A