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DEPOSITION - Decreasing Postoperative Blood Loss by Topical vs. Intravenous Tranexamic Acid in Open Cardiac Surgery
Sponsor: Population Health Research Institute
Summary
The aim is to conduct a double-dummy multi-centre randomized controlled clinical trial of application of topical dose of tranexamic acid (TxA) versus the usual intravenous TxA in patients undergoing on-pump cardiac surgery.
Official title: Decreasing Postoperative Blood Loss by Topical vs. Intravenous Tranexamic Acid in Open Cardiac Surgery (DEPOSITION) Study
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
3242
Start Date
2019-09-17
Completion Date
2023-11-28
Last Updated
2026-10-26
Healthy Volunteers
No
Conditions
Interventions
Tranexamic Acid
Tranexamic Acid is a medication used to treat or prevent excessive blood loss from major trauma, post partum, surgery, tooth removal, nose bleeds, and heavy menstruation.
Locations (16)
Kelowna General Hospital
Kelowna, British Columbia, Canada
St. Boniface Hospital
Winnipeg, Manitoba, Canada
Saint John Regional Hospital
Saint John, New Brunswick, Canada
Hamilton Health Sciences - General Hospital
Hamilton, Ontario, Canada
CHUM
Montreal, Ontario, Canada
Montreal Heart Institute
Montreal, Quebec, Canada
CIUSSS NIM/Hôpital Sacré-Coeur de Montréal
Montreal, Quebec, Canada
IUCPQ
Québec, Quebec, Canada
Beijing Anzhen Hospital
Beijing, China
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Shanghai, China
Nemocnice Agel Třinec
Třinec, Czechia
University of Malaya
Kuala Lumpur, Malaysia
Auckland City Hospital
Auckland, New Zealand
Petrovsky National Research Centre
Moscow, Russia
E.Meshalkin National Medical Research Center
Novosibirsk, Russia
Saint-Petersburg State University Hospital
Saint Petersburg, Russia