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Assessing the Impact of Lipoprotein (a) Lowering With Pelacarsen (TQJ230) on Major Cardiovascular Events in Patients With CVD
Sponsor: Novartis Pharmaceuticals
Summary
This is a pivotal phase 3 study designed to support an indication for the reduction of cardiovascular risk in patients with established CVD and elevated Lp(a)
Official title: A Randomized Double-blind, Placebo-controlled, Multicenter Trial Assessing the Impact of Lipoprotein (a) Lowering With Pelacarsen (TQJ230) on Major Cardiovascular Events in Patients With Established Cardiovascular Disease
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
8323
Start Date
2019-12-12
Completion Date
2026-07-16
Last Updated
2026-08-28
Healthy Volunteers
No
Interventions
TQJ230
TQJ230 80 mg injected monthly administered subcutaneously
Placebo
Placebo to match TQJ230 prefilled syringe to be injected subcutaneously
Locations (902)
SEC Clinical Research LLC
Andalusia, Alabama, United States
Grandview Med Group Research LLC
Birmingham, Alabama, United States
Novartis Investigative Site
Birmingham, Alabama, United States
Heart Center Research Llc
Huntsville, Alabama, United States
Novartis Investigative Site
Huntsville, Alabama, United States
Mobile Heart Specialists
Mobile, Alabama, United States
Novartis Investigative Site
Mobile, Alabama, United States
Novartis Investigative Site
Cottonwood, Arizona, United States
Mercy Gilbert Medical Center
Gilbert, Arizona, United States
Clinical Research Inst of Arizona
Sun City West, Arizona, United States
Novartis Investigative Site
Sun City West, Arizona, United States
Eclipse Clinical Research
Tucson, Arizona, United States
Novartis Investigative Site
Tucson, Arizona, United States
Cardiology and Medicine Clinic PA
Little Rock, Arkansas, United States
Novartis Investigative Site
Little Rock, Arkansas, United States
Cardiovascular Res Found
Beverly Hills, California, United States
National Heart Institute
Beverly Hills, California, United States
Novartis Investigative Site
Beverly Hills, California, United States
Flourish Clinical Resrch Covin
Covina, California, United States
Novartis Investigative Site
Covina, California, United States
Diabetes Lipid Management Center
Huntington Beach, California, United States
Novartis Investigative Site
Huntington Beach, California, United States
University of Calif Irvine Med Cntr
Irvine, California, United States
Novartis Investigative Site
La Jolla, California, United States
Memorial Care Health System
Long Beach, California, United States
Novartis Investigative Site
Long Beach, California, United States
Keck Medical Center USC
Los Angeles, California, United States
Novartis Investigative Site
Los Angeles, California, United States
Novartis Investigative Site
Los Angeles, California, United States
Novartis Investigative Site
Northridge, California, United States
Valley Clinical Trials
Northridge, California, United States
Novartis Investigative Site
Orange, California, United States
Stanford University Medical Center
Palo Alto, California, United States
University of California San Diego
San Diego, California, United States
UCSF
San Francisco, California, United States
Novartis Investigative Site
San Francisco, California, United States
Helping Hands Medical Associates INC
Santa Ana, California, United States
Novartis Investigative Site
Santa Ana, California, United States
Novartis Investigative Site
Stanford, California, United States
Manshadi Heart Institute
Stockton, California, United States
Novartis Investigative Site
Stockton, California, United States
Interv Cardiology Med Grp
West Hills, California, United States
Novartis Investigative Site
West Hills, California, United States
Novartis Investigative Site
Aurora, Colorado, United States
Univ Of Color Anschutz Med Center
Aurora, Colorado, United States
Bridgeport Hospital
Bridgeport, Connecticut, United States
Novartis Investigative Site
Bridgeport, Connecticut, United States
Novartis Investigative Site
Hartford, Connecticut, United States
Hartford Hospital
Hartford, Connecticut, United States
Chase Medical Research LLC
Waterbury, Connecticut, United States
Novartis Investigative Site
Waterbury, Connecticut, United States
Excel Medical Clinical Trials LLC
Boca Raton, Florida, United States
Novartis Investigative Site
Boca Raton, Florida, United States
Cardiovascular and Vein Center of Florida
Bradenton, Florida, United States
Novartis Investigative Site
Bradenton, Florida, United States
Bay Area Cardiology Assoc
Brandon, Florida, United States
Novartis Investigative Site
Brandon, Florida, United States
Novartis Investigative Site
Fort Lauderdale, Florida, United States
CV Consultants of South Broward
Hollywood, Florida, United States
Novartis Investigative Site
Jacksonville, Florida, United States
Westside Center for Clinical Research
Jacksonville, Florida, United States
East Coast Institute for Research
Jacksonville, Florida, United States
Jacksonville Center for Clinical Research
Jacksonville, Florida, United States
Novartis Investigative Site
Jacksonville, Florida, United States
Infinite Clinical Research
Miami, Florida, United States
Novartis Investigative Site
Miami, Florida, United States
Advanced Research for Health Improvement LLC
Naples, Florida, United States
Novartis Investigative Site
Naples, Florida, United States
Southwest Florida Research
Naples, Florida, United States
Novartis Investigative Site
Port Charlotte, Florida, United States
Peace River Cardiovascular Center
Port Charlotte, Florida, United States
Novartis Investigative Site
Port Orange, Florida, United States
Progressive Medical Research
Port Orange, Florida, United States
East Coast Inst for Research LLC
Saint Augustine, Florida, United States
Novartis Investigative Site
Saint Augustine, Florida, United States
Cardiology Partners Clinical Research Institute
Wellington, Florida, United States
Novartis Investigative Site
Wellington, Florida, United States
Novartis Investigative Site
Atlanta, Georgia, United States
Grady Health System
Atlanta, Georgia, United States
Novartis Investigative Site
Atlanta, Georgia, United States
Piedmont Heart Institute
Atlanta, Georgia, United States
Emory University
Atlanta, Georgia, United States
Novartis Investigative Site
Atlanta, Georgia, United States
Novartis Investigative Site
Dunwoody, Georgia, United States
Alta Pharmaceutical Research Center
Peachtree Corners, Georgia, United States
Cardiovascular Consultants of S GA
Thomasville, Georgia, United States
Novartis Investigative Site
Thomasville, Georgia, United States
Rush University Medical Center
Chicago, Illinois, United States
Advocate Lutheran General Childrens Hospital
Park Ridge, Illinois, United States
Novartis Investigative Site
Park Ridge, Illinois, United States
Novartis Investigative Site
Indianapolis, Indiana, United States
Krannert Institute of Cardiology
Indianapolis, Indiana, United States
Novartis Investigative Site
Iowa City, Iowa, United States
Uni Of Iowa Hospitals And Clinics
Iowa City, Iowa, United States
Novartis Investigative Site
Kansas City, Kansas, United States
University of Kansas Hospital
Kansas City, Kansas, United States
Cotton O Neil Clinical Res Center
Topeka, Kansas, United States
Novartis Investigative Site
Topeka, Kansas, United States
Christus Health Central Louisiana
Alexandria, Louisiana, United States
Novartis Investigative Site
Alexandria, Louisiana, United States