Clinical Research Directory
Browse clinical research sites, groups, and studies.
Trigger Timing in Ovarian Stimulations
Sponsor: Peking University Third Hospital
Summary
The gonadotrophin-releasing hormone (GnRH) antagonist protocol is widely used in in vitro fertilisation (IVF) for its flexibility and ability to reduce the risk of ovarian hyperstimulation syndrome (OHSS). Conventionally, the trigger criterion is set at ≥3 follicles ≥17 mm. Whether this criterion is premature and whether a 1-2 day delay could improve the number of good-quality embryos and cumulative live birth rate, requires prospective evaluation. While delaying the trigger could theoretically allow for more complete follicular maturation and improve oocyte yield, existing evidence is contradictory; some studies report increased oocyte numbers without a corresponding improvement in live birth rates, potentially due to adverse endometrial changes. Therefore, this randomised controlled trial (RCT) aims to determine whether a one- to two-day delay in triggering ovulation, compared to the conventional criterion, increases the number of good-quality embryos and improves cumulative live birth rates in women undergoing IVF or intracytoplasmic sperm injection (ICSI).
Official title: Comparison of Regular Trigger Timing and 1-2 Days Delay of Trigger in Ovarian Stimulations by GnRH Antagonist Protocol in in Vitro Fertilization
Key Details
Gender
FEMALE
Age Range
18 Years - 42 Years
Study Type
INTERVENTIONAL
Enrollment
834
Start Date
2020-04-01
Completion Date
2028-03-31
Last Updated
2026-11-02
Healthy Volunteers
No
Conditions
Interventions
1-2 days later trigger than regular timing
During ovarian stimulation, 1-2 days later of trigger after three follicles reach 17mm bilateral with contineous using of Gonadotrophin in antagonist protocol.
Locations (1)
Peking Univesity Third Hospital
Beijing, Beijing Municipality, China