Clinical Research Directory

Inclusion Criteria: 1. Patients treated in paediatric dialysis centres between 5-20 years of age 2. Receiving maintenance haemodialysis with HD or HDF for the preceding 3 months 3. In post-dilution HDF for at least 4 weeks before the start of the study 4. Patients with stable vascular access (central line or arteriovenous fistula) and no plan to change access modality for the duration of the study 5. Provision for ultrapure water for HDF (defined as containing \<0.1 colony forming unit /ml and \<0.03 endotoxin unit/ml) documented in the month prior to study start Exclusion Criteria: 1. Incident dialysis patients (on HD or HDF for \< 3 months) 2. Patients with acute infections in the preceding 2 weeks 3. Patients with underlying chronic inflammatory disorders (Including vasculitis) 4. Single pool Kt/V less than 1.2 in the month prior to the study start. 5. Children who have haemoglobin concentrations lower than 10 g/dL