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A Study to Evaluate the Effect of Genetic Variation on Beta-cell Function During Fasting and Hyperglycemia in Nondiabetics
Sponsor: Adrian Vella
Summary
The GLP-1 receptor (GLP1R) gene is found on the beta cells of the pancreas. Its role is in the control of blood sugar level by enhancing insulin secretion from the pancreas after eating a meal. The purpose of this research study to find out how genetic variations in GLP1R alter insulin secretion, in the fasting state and when blood sugars levels are elevated.
Official title: Effect of Genetic Variation in the GLP-1 Receptor on Beta-cell Function During Fasting and Hyperglycemia in Nondiabetic Humans
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
21
Start Date
2022-10-17
Completion Date
2025-12-30
Last Updated
2026-10-28
Healthy Volunteers
Yes
Conditions
Interventions
Saline
Saline will serve as the control
Exendin-9,39
Exendin-9,39 will block the GLP-1 receptor
Liraglutide
Liraglutide will serve as the GLP-1 receptor agonist/stimulator
Locations (1)
Mayo Clinic in Rochester
Rochester, Minnesota, United States