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Study of Trastuzumab Deruxtecan (T-DXd) vs Investigator's Choice Chemotherapy in HER2-low, Hormone Receptor Positive, Metastatic Breast Cancer
Sponsor: AstraZeneca
Summary
This study will evaluate the efficacy, safety and tolerability of trastuzumab deruxtecan compared with investigator's choice chemotherapy in human epidermal growth factor receptor (HER)2-low, hormone receptor (HR) positive breast cancer patients whose disease has progressed on endocrine therapy in the metastatic setting.
Official title: A Phase 3, Randomized, Multi-center, Open-label Study of Trastuzumab Deruxtecan (T-DXd) Versus Investigator's Choice Chemotherapy in HER2-Low, Hormone Receptor Positive Breast Cancer Patients Whose Disease Has Progressed on Endocrine Therapy in the Metastatic Setting (DESTINY-Breast06)
Key Details
Gender
All
Age Range
18 Years - 105 Years
Study Type
INTERVENTIONAL
Enrollment
866
Start Date
2020-07-24
Completion Date
2026-06-19
Last Updated
2026-03-04
Healthy Volunteers
No
Conditions
Interventions
Trastuzumab deruxtecan
Trastuzumab deruxtecan by intravenous infusion
Capecitabine
Investigator's choice standard of care single agent chemotherapy; capecitabine tablets will be given orally.
Paclitaxel
Investigator's choice standard of care single agent chemotherapy; paclitaxel by intravenous infusion.
Nab-Paclitaxel
Investigator's choice standard of care single agent chemotherapy; nab-paclitaxel by intravenous infusion
Locations (293)
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Scottsdale, Arizona, United States
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Springdale, Arkansas, United States
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Duarte, California, United States
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Los Angeles, California, United States
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Aurora, Colorado, United States
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Lakewood, Colorado, United States
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Washington D.C., District of Columbia, United States
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Jacksonville, Florida, United States
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Kansas City, Kansas, United States
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Louisville, Kentucky, United States
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Bethesda, Maryland, United States
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Boston, Massachusetts, United States
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Detroit, Michigan, United States
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Rochester, Minnesota, United States
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St Louis, Missouri, United States
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Summit, New Jersey, United States
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Westbury, New York, United States
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Columbus, Ohio, United States
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Pittsburgh, Pennsylvania, United States
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Nashville, Tennessee, United States
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Austin, Texas, United States
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Dallas, Texas, United States
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Houston, Texas, United States
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Houston, Texas, United States
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Norfolk, Virginia, United States
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Seattle, Washington, United States
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Madison, Wisconsin, United States
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Buenos Aires, Argentina
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CABA, Argentina
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CABA, Argentina
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CABA, Argentina
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Ciudad de Buenos Aires, Argentina
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Córdoba, Argentina
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La Plata, Argentina
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Mar del Plata, Argentina
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Rosario, Argentina
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Rosario, Argentina
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Adelaide, Australia
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Birtinya, Australia
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Darlinghurst, Australia
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Murdoch, Australia
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South Brisbane, Australia
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St Leonards, Australia
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Waratah, Australia
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Graz, Austria
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Innsbruck, Austria
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Anderlecht, Belgium
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Brussels, Belgium
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Charleroi, Belgium
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Edegem, Belgium
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Ghent, Belgium
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Leuven, Belgium
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Liège, Belgium
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Namur, Belgium
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Roeselare, Belgium
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Sint-Niklaas, Belgium
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Barretos, Brazil
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Belo Horizonte, Brazil
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Natal, Brazil
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Porto Alegre, Brazil
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Porto Alegre, Brazil
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Rio de Janeiro, Brazil
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São Paulo, Brazil
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São Paulo, Brazil
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Sorocaba, Brazil
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Calgary, Alberta, Canada
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Edmonton, Alberta, Canada
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Vancouver, British Columbia, Canada
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Toronto, CA, Canada
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London, Ontario, Canada
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Toronto, Ontario, Canada
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Toronto, Ontario, Canada
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Montreal, Quebec, Canada
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Montreal, Quebec, Canada
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Sherbrooke, Quebec, Canada
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Baoding, China
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Beijing, China
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Beijing, China
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Changchun, China
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Changsha, China
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Changsha, China
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Dalian, China
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Foshan, China
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Fuzhou, China
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Guangzhou, China
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Guangzhou, China
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Guangzhou, China
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Hangzhou, China
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Hangzhou, China
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Hangzhou, China
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Harbin, China
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Hefei, China
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Jinan, China
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Linyi, China
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Nanchang, China
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Nanchang, China
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Nanjing, China
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Nanjing, China
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Nanning, China
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Shanghai, China