Clinical Research Directory
Browse clinical research sites, groups, and studies.
A Combination of Acalabrutinib With R-CHOP in Subjects With Previously Untreated Non-GCB DLBCL (ACE-LY-312)
Sponsor: Acerta Pharma BV
Summary
Phase 3 randomized, double-blind, placebo-controlled, study assessing the efficacy and safety of acalabrutinib plus rituximab,cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) vs placebo plus R-CHOP in subjects ≤75 years of age with previously untreated non-germinal center diffuse large B-cell lymphoma.
Official title: Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Acalabrutinib in Combination With Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Subjects ≤75 Years With Previously Untreated Non-GCB DLBCL
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
611
Start Date
2020-10-08
Completion Date
2027-02-22
Last Updated
2026-10-13
Healthy Volunteers
No
Conditions
Interventions
acalabrutinib
Investigational Product
placebo
Placebo comparator
Prednisone
Investigational Product
Rituximab
Investigational Product
Cyclophosphamide
Investigational Product
Vincristine
Investigational Product
Doxorubicin
Investigational Product
Locations (245)
Research Site
Tucson, Arizona, United States
Research Site
Little Rock, Arkansas, United States
Research Site
Irvine, California, United States
Research Site
Aurora, Colorado, United States
Research Site
Norwich, Connecticut, United States
Research Site
Fort Myers, Florida, United States
Research Site
Orlando, Florida, United States
Research Site
St. Petersburg, Florida, United States
Research Site
Tallahassee, Florida, United States
Research Site
West Palm Beach, Florida, United States
Research Site
Fort Wayne, Indiana, United States
Research Site
Des Moines, Iowa, United States
Research Site
Wichita, Kansas, United States
Research Site
Louisville, Kentucky, United States
Research Site
Baltimore, Maryland, United States
Research Site
Grand Rapids, Michigan, United States
Research Site
Minneapolis, Minnesota, United States
Research Site
St Louis, Missouri, United States
Research Site
Albany, New York, United States
Research Site
New York, New York, United States
Research Site
New York, New York, United States
Research Site
Stony Brook, New York, United States
Research Site
Charlotte, North Carolina, United States
Research Site
Winston-Salem, North Carolina, United States
Research Site
Eugene, Oregon, United States
Research Site
Portland, Oregon, United States
Research Site
Philadelphia, Pennsylvania, United States
Research Site
Pittsburgh, Pennsylvania, United States
Research Site
Nashville, Tennessee, United States
Research Site
Fort Sam Houston, Texas, United States
Research Site
Lubbock, Texas, United States
Research Site
Salem, Virginia, United States
Research Site
Adelaide, Australia
Research Site
Camperdown, Australia
Research Site
Darlinghurst, Australia
Research Site
Heidelberg, Australia
Research Site
Hobart, Australia
Research Site
Kogarah, Australia
Research Site
Nedlands, Australia
Research Site
Westmead, Australia
Research Site
Linz, Austria
Research Site
Wels, Austria
Research Site
Antwerp, Belgium
Research Site
Bruges, Belgium
Research Site
La Louvière, Belgium
Research Site
Goiânia, Brazil
Research Site
Passo Fundo, Brazil
Research Site
Porto Alegre, Brazil
Research Site
Porto Alegre, Brazil
Research Site
Ribeirão Preto, Brazil
Research Site
Rio de Janeiro, Brazil
Research Site
São Paulo, Brazil
Research Site
São Paulo, Brazil
Research Site
São Paulo, Brazil
Research Site
São Paulo, Brazil
Research Site
Vancouver, British Columbia, Canada
Research Site
Toronto, CA, Canada
Research Site
Winnipeg, Manitoba, Canada
Research Site
London, Ontario, Canada
Research Site
Lévis, Quebec, Canada
Research Site
Montreal, Quebec, Canada
Research Site
Montreal, Quebec, Canada
Research Site
Québec, Quebec, Canada
Research Site
Ottawa, Canada
Research Site
Toronto, Canada
Research Site
Beijing, China
Research Site
Beijing, China
Research Site
Changchun, China
Research Site
Chengdu, China
Research Site
Guangzhou, China
Research Site
Guangzhou, China
Research Site
Guangzhou, China
Research Site
Hangzhou, China
Research Site
Hangzhou, China
Research Site
Harbin, China
Research Site
Jinan, China
Research Site
Luoyang, China
Research Site
Nanchang, China
Research Site
Nanning, China
Research Site
Shanghai, China
Research Site
Shanghai, China
Research Site
Shenyang, China
Research Site
Shenyang, China
Research Site
Shijiazhuang, China
Research Site
Suzhou, China
Research Site
Tianjin, China
Research Site
Tianjin, China
Research Site
Wuhan, China
Research Site
Wuhan, China
Research Site
Xiamen, China
Research Site
Zhengzhou, China
Research Site
Brno, Czechia
Research Site
Hradec Králové, Czechia
Research Site
Ostrava - Poruba, Czechia
Research Site
Pilsen, Czechia
Research Site
Prague, Czechia
Research Site
Prague, Czechia
Research Site
Brest, France
Research Site
Caen, France
Research Site
Marseille, France