Tundra Space

Tundra Space

Clinical Research Directory

Browse clinical research sites, groups, and studies.

Back to Studies
COMPLETED
NCT04549155
NA

Network-guided TMS in Early Alzheimer's Disease

Sponsor: Duke University

View on ClinicalTrials.gov

Summary

The proposed research will test a novel network-based neurostimulation approach using MRI-derived measures of brain connectivity to establish target sites for neurostimulation and test for the enhancement of memory function beyond a sham stimulation condition. This will be tested in cohort of MCI adults using network-based transcranial magnetic stimulation (TMS) to assess for behavioral improvement due to the controlled intervention. This study will provide important evidence towards the efficacy of neuromodulatory treatments for memory decline and will accelerate the discovery of potent non-invasive treatments to remediate cognitive decline in cognitively impaired older adults.

Official title: Using Network-guided TMS to Ameliorate Memory Deficits in Early Alzheimer's Disease

Key Details

Gender

All

Age Range

60 Years - 82 Years

Study Type

INTERVENTIONAL

Enrollment

37

Start Date

2022-03-08

Completion Date

2025-06-27

Last Updated

2026-10-27

Healthy Volunteers

Yes

Interventions

DEVICE

Transcranial Magnetic Stimulation

Transcranial magnetic stimulation (TMS) is a noninvasive procedure that uses magnetic fields to stimulate nerve cells in the brain to improve a variety of cognitive conditions, and to probe the dynamics of normal brain function.

Locations (1)

Duke University Medical Center

Durham, North Carolina, United States