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Network-guided TMS in Early Alzheimer's Disease
Sponsor: Duke University
Summary
The proposed research will test a novel network-based neurostimulation approach using MRI-derived measures of brain connectivity to establish target sites for neurostimulation and test for the enhancement of memory function beyond a sham stimulation condition. This will be tested in cohort of MCI adults using network-based transcranial magnetic stimulation (TMS) to assess for behavioral improvement due to the controlled intervention. This study will provide important evidence towards the efficacy of neuromodulatory treatments for memory decline and will accelerate the discovery of potent non-invasive treatments to remediate cognitive decline in cognitively impaired older adults.
Official title: Using Network-guided TMS to Ameliorate Memory Deficits in Early Alzheimer's Disease
Key Details
Gender
All
Age Range
60 Years - 82 Years
Study Type
INTERVENTIONAL
Enrollment
37
Start Date
2022-03-08
Completion Date
2025-06-27
Last Updated
2026-10-27
Healthy Volunteers
Yes
Conditions
Interventions
Transcranial Magnetic Stimulation
Transcranial magnetic stimulation (TMS) is a noninvasive procedure that uses magnetic fields to stimulate nerve cells in the brain to improve a variety of cognitive conditions, and to probe the dynamics of normal brain function.
Locations (1)
Duke University Medical Center
Durham, North Carolina, United States