Clinical Research Directory

Inclusion Criteria: 1. Males or females ≥ 12 years of age 2. Otherwise healthy and well controlled subjects Exclusion Criteria: Ophthalmic (in either eye): 1. Clinically significant ocular disease as deemed by the Investigator that might interfere with the study 2. Unwilling or unable to discontinue use of contact lenses at screening until study completion 3. Unwilling or unable to suspend use of topical medication at screening until study completion 4. Ocular trauma, ocular surgery or non-refractive laser treatment within the 6 months prior to screening 5. Use of any topical prescription or over-the-counter (OTC) ophthalmic medications of any kind within 7 days of screening 6. Recent or current evidence of ocular infection or inflammation in either eye 7. History of diabetic retinopathy or diabetic macular edema 8. Closed or very narrow angles that in the Investigator's opinion are potentially occludable if the subject's pupil is dilated 9. History of any traumatic (surgical or nonsurgical) or non-traumatic condition affecting the pupil or iris 10. Known allergy or contraindication to any component of the mydriatic agents or the vehicle formulation 11. History of cauterization of the punctum or punctal plug (silicone or collagen) insertion or removal Systemic: 1. Known hypersensitivity or contraindication to α- and/or β adrenoceptor antagonists. 2. Clinically significant systemic disease that might interfere with the study 3. Initiation of treatment with or any changes to the current dosage, drug or regimen of any systemic adrenergic or cholinergic drugs within 7 days prior to screening, or during the study 4. Participation in any investigational study within 30 days prior to screening 5. Females of childbearing potential who are pregnant, nursing, planning a pregnancy, or not using a medically acceptable form of birth control 6. Resting HR outside the normal range (50-110 beats per minute) 7. Hypertension with resting diastolic BP \> 105 mmHg or systolic BP \> 160 mmHg