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COMT Activity and Hypnotizability
Sponsor: Stanford University
Summary
Hypnosis is an effective pain management tool for surgery that can reduce opioid use up to 40%. COMT single nucleotide polymorphisms (SNPs) can predict pain sensitivity and opioid use perioperatively, and may also be associated with hypnotizability or response to hypnotic analgesia. Analyzing COMT haplotypes from DNA extracted from saliva or blood using a giant magnetoresistive (GMR) nanotechnology platform may be faster, less expensive, and at least as accurate as pyrosequencing. This study aims to validate a multi-SNP point-of-care (POC) GMR assay for the rapid genotyping of SNPs predictive of COMT activity, and test the feasibility of using COMT activity as a biomarker for hypnotizability and/or response to hypnotic analgesia.
Official title: COMT Activity as a Biomarker for Hypnotizability and Hypnotic Analgesia Using a Multiplexed Precision Medicine Platform
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
80
Start Date
2021-01-13
Completion Date
2021-07-13
Last Updated
2026-04-09
Healthy Volunteers
No
Interventions
Giant magnetoresistive sensor (GMR)
Giant magnetoresistive sensor analyzes genetic polymorphisms in patient samples.
Locations (1)
Stanford University/Stanford Healthcare
Palo Alto, California, United States