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Phase 3 Study of MRTX849 (Adagrasib) vs Docetaxel in Patients With Advanced Non-Small Cell Lung Cancer With KRAS G12C Mutation
Sponsor: Mirati Therapeutics Inc.
Summary
This Phase 3 study will evaluate the efficacy of the investigational agent MRTX849 (adagrasib) versus docetaxel in patients who have been previously treated for metastatic NSCLC with a KRAS G12C mutation.
Official title: A Randomized Phase 3 Study of MRTX849 Versus Docetaxel in Patients With Previously Treated Non-Small Cell Lung Cancer With KRAS G12C Mutation
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
453
Start Date
2021-02-23
Completion Date
2026-10-30
Last Updated
2026-08-11
Healthy Volunteers
No
Interventions
MRTX849
21 day cycles
Docetaxel
21 day cycles
Locations (380)
Local Institution - 012-898
Cerritos, California, United States
Local Institution - 012-910
Duarte, California, United States
Local Institution - 012-898 D
Glendale, California, United States
Local Institution - 012-910-A
Huntington Beach, California, United States
Local Institution - 012-910-C
Irvine, California, United States
Local Institution - 012-910-B
Long Beach, California, United States
Local Institution - 012-910-F
Long Beach, California, United States
Local Institution - 012-910-D
Newport Beach, California, United States
Local Institution - 012-898 C
Santa Ana, California, United States
Local Institution - 012-858
Santa Rosa, California, United States
Local Institution - 012-910-E
Torrance, California, United States
Local Institution - 012-951-B
Denver, Colorado, United States
Local Institution - 012-951
Lafayette, Colorado, United States
Local Institution - 012-872
Lone Tree, Colorado, United States
Local Institution - 012-951-A
Wheat Ridge, Colorado, United States
Local Institution - 012-562-B
Fleming Island, Florida, United States
Local Institution - 012-968
Fort Lauderdale, Florida, United States
Local Institution - 012-562-D
Jacksonville, Florida, United States
Local Institution - 012-853
Jacksonville, Florida, United States
Local Institution - 012-562-E
Jacksonville, Florida, United States
Local Institution - 012-562-A
Jacksonville, Florida, United States
Local Institution - 012-562-C
Jacksonville, Florida, United States
Local Institution - 012-562-F
Jacksonville, Florida, United States
Local Institution - 012-562-G
Jacksonville, Florida, United States
Local Institution - 012-562
Jacksonville, Florida, United States
Local Institution - 012-825
Miami Beach, Florida, United States
Local Institution - 012-973
Orlando, Florida, United States
Local Institution - 012-877
Pensacola, Florida, United States
Local Institution - 012-839
Plantation, Florida, United States
Local Institution - 012-941
Athens, Georgia, United States
Local Institution - 012-835 - A
Austell, Georgia, United States
Local Institution - 012-835 - B
Carrollton, Georgia, United States
Local Institution - 012-835 - C
Cartersville, Georgia, United States
Local Institution - 012-835 - D
Douglasville, Georgia, United States
Local Institution - 012-835
Marietta, Georgia, United States
Local Institution - 012-917
Chicago, Illinois, United States
Local Institution - 012-972
Chicago, Illinois, United States
Local Institution - 012-972 C
Harvey, Illinois, United States
Local Institution - 012-972 A
New Lenox, Illinois, United States
Local Institution - 012-883
Niles, Illinois, United States
Local Institution - 012-972 B
Orland Park, Illinois, United States
Local Institution - 012-943
Goshen, Indiana, United States
Local Institution - 012-569
Indianapolis, Indiana, United States
Local Institution - 012-569 - B
Lafayette, Indiana, United States
Local Institution - 012-569 - C
Lafayette, Indiana, United States
Local Institution - 012-569 - A
Mooresville, Indiana, United States
Local Institution - 012-782
Munster, Indiana, United States
Local Institution - 012-942-B
Chanute, Kansas, United States
Local Institution - 012-942-C
Dodge City, Kansas, United States
Local Institution - 012-942-D
El Dorado, Kansas, United States
Local Institution - 012-942-E
Independence, Kansas, United States
Local Institution - 012-942-F
Kingman, Kansas, United States
Local Institution - 012-942-G
Liberal, Kansas, United States
Local Institution - 012-942-H
McPherson, Kansas, United States
Local Institution - 012-942-I
Newton, Kansas, United States
Local Institution - 012-942-J
Parsons, Kansas, United States
Local Institution - 012-942-K
Pratt, Kansas, United States
Local Institution - 012-942-L
Salina, Kansas, United States
Local Institution - 012-942-M
Wellington, Kansas, United States
Local Institution - 012-820
Westwood, Kansas, United States
Local Institution - 012-942-A
Wichita, Kansas, United States
Local Institution - 012-942
Wichita, Kansas, United States
Local Institution - 012-942-N
Winfield, Kansas, United States
Local Institution - 012-965
Lexington, Kentucky, United States
Local Institution - 012-911 A
New Orleans, Louisiana, United States
Local Institution - 012-911
New Orleans, Louisiana, United States
Local Institution - 012-954 - A
Kennebunk, Maine, United States
Local Institution - 012-954
Scarborough, Maine, United States
Local Institution - 012-954 - B
Topsham, Maine, United States
Local Institution - 012-856
Frederick, Maryland, United States
Local Institution - 012-974-B
Novi, Michigan, United States
Local Institution - 012-974-C
Novi, Michigan, United States
Local Institution - 012-974-A
Southfield, Michigan, United States
Local Institution - 012-974
Southfield, Michigan, United States
Local Institution - 012-952
Bolivar, Missouri, United States
Local Institution - 012-841 - A
Billings, Montana, United States
Local Institution - 012-841
Billings, Montana, United States
Local Institution - 012-846
Billings, Montana, United States
Local Institution - 012-975
East Brunswick, New Jersey, United States
Local Institution - 012-975 - A
Edison, New Jersey, United States
Local Institution - 012-975 - B
Monroe, New Jersey, United States
Local Institution - 012-975 - C
Somerset, New Jersey, United States
Local Institution - 012-975 - D
Somerville, New Jersey, United States
Local Institution - 012-577
Teaneck, New Jersey, United States
Local Institution - 012-962
Syracuse, New York, United States
Local Institution - 012-849
Cleveland, Ohio, United States
Local Institution - 012-836
Kettering, Ohio, United States
Local Institution - 012-967
Salem, Oregon, United States
Local Institution - 012-960
Providence, Rhode Island, United States
Local Institution - 012-960-A
Providence, Rhode Island, United States
Local Institution - 012-891
Greenville, South Carolina, United States
Local Institution - 012-940
Sioux Falls, South Dakota, United States
Local Institution - 012-888
Arlington, Texas, United States
Local Institution - 012-892
Austin, Texas, United States
Local Institution - 012-999
Irving, Texas, United States
Local Institution - 012-890
Sherman, Texas, United States
Local Institution - 012-976
Salt Lake City, Utah, United States
Local Institution - 012-976-A
Salt Lake City, Utah, United States
Local Institution - 012-976-B
Salt Lake City, Utah, United States
Local Institution - 012-976-C
Salt Lake City, Utah, United States