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Phase 3 Study of MRTX849 With Cetuximab vs Chemotherapy in Patients With Advanced Colorectal Cancer With KRAS G12C Mutation (KRYSTAL-10)
Sponsor: Mirati Therapeutics Inc.
Summary
Study CA239-0006 is an open-label, randomized Phase 3 clinical trial comparing the efficacy of MRTX849 administered in combination with cetuximab versus chemotherapy in the second-line treatment setting in patients with CRC with KRAS G12C mutation.
Official title: A Randomized Phase 3 Study of MRTX849 in Combination With Cetuximab Versus Chemotherapy in Patients With Advanced Colorectal Cancer With KRAS G12C Mutation With Disease Progression On or After Standard First-Line Therapy
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
461
Start Date
2021-06-24
Completion Date
2026-10-23
Last Updated
2026-09-28
Healthy Volunteers
No
Interventions
MRTX849
28 Day Cycle
Cetuximab
28 Day Cycle
mFOLFOX6 Regimen
* Fluorouracil * Oxaliplatin * Folinic acid
FOLFIRI Regimen
* Fluorouracil * Irinotecan * Folinic acid
Locations (419)
Local Institution - 010-855-E
Alabaster, Alabama, United States
Local Institution - 010-855-B
Bessemer, Alabama, United States
Local Institution - 010-855-D
Birmingham, Alabama, United States
Local Institution - 010-855-A
Birmingham, Alabama, United States
Local Institution - 010-855-F
Birmingham, Alabama, United States
Local Institution - 010-855-C
Birmingham, Alabama, United States
Local Institution - 010-855
Birmingham, Alabama, United States
Local Institution - 010-996
Gilbert, Arizona, United States
Local Institution - 010-566
Goodyear, Arizona, United States
Local Institution - 010-989
Phoenix, Arizona, United States
Local Institution - 010-978
Springdale, Arkansas, United States
Local Institution - 010-573
Bakersfield, California, United States
Local Institution - 010-979C
Chula Vista, California, United States
Local Institution - 010-980
Fresno, California, United States
Local Institution - 010-851
Fullerton, California, United States
Local Institution - 010-979A
La Mesa, California, United States
Local Institution - 010-958A
Los Angeles, California, United States
Local Institution - 010-958
Los Angeles, California, United States
Local Institution - 010-551
Los Angeles, California, United States
Local Institution - 010-847
Newport Beach, California, United States
Local Institution - 010-563
Redlands, California, United States
Local Institution - 010-979B
San Diego, California, United States
Local Institution - 010-979D
San Diego, California, United States
Local Institution - 010-979
San Diego, California, United States
Local Institution - 010-982
San Francisco, California, United States
Local Institution - 010-561
Santa Monica, California, United States
Local Institution - 010-571
Sylmar, California, United States
Local Institution - 010-574
Torrance, California, United States
Local Institution - 010-570
Whittier, California, United States
Local Institution - 010-872-H
Aurora, Colorado, United States
Local Institution - 010-810
Aurora, Colorado, United States
Local Institution - 010-872-A
Boulder, Colorado, United States
Local Institution - 010-872-E
Centennial, Colorado, United States
Local Institution - 010-872-C
Colorado Springs, Colorado, United States
Local Institution - 010-872
Denver, Colorado, United States
Local Institution - 010-872-B
Denver, Colorado, United States
Local Institution - 010-872-J
Lakewood, Colorado, United States
Local Institution - 010-872-F
Littleton, Colorado, United States
Local Institution - 010-872-G
Longmont, Colorado, United States
Local Institution - 010-872-I
Pueblo, Colorado, United States
Local Institution - 010-872-D
Thornton, Colorado, United States
Local Institution - 010-949
Norwich, Connecticut, United States
Local Institution - 010-922-A
Bonita Springs, Florida, United States
Local Institution - 010-922-D
Bradenton, Florida, United States
Local Institution - 010-922-E
Cape Coral, Florida, United States
Local Institution - 010-922
Fort Myers, Florida, United States
Local Institution - 010-922-B
Fort Myers, Florida, United States
Local Institution - 010-922-C
Fort Myers, Florida, United States
Local Institution - 010-984-B
Holiday, Florida, United States
Local Institution - 010-829
Jacksonville, Florida, United States
Local Institution - 010-923-A
Largo, Florida, United States
Local Institution - 010-923-B
Largo, Florida, United States
Local Institution - 010-923-C
Largo, Florida, United States
Local Institution - 010-923-D
Largo, Florida, United States
Local Institution - 010-923-E
Largo, Florida, United States
Local Institution - 010-923-F
Largo, Florida, United States
Local Institution - 010-923-G
Largo, Florida, United States
Local Institution - 010-923-H
Largo, Florida, United States
Local Institution - 010-923-I
Largo, Florida, United States
Local Institution - 010-923-J
Largo, Florida, United States
Local Institution - 010-923-K
Largo, Florida, United States
Local Institution - 010-923-L
Largo, Florida, United States
Local Institution - 010-923-M
Largo, Florida, United States
Local Institution - 010-923-N
Largo, Florida, United States
Local Institution - 010-923-O
Largo, Florida, United States
Local Institution - 010-923-P
Largo, Florida, United States
Local Institution - 010-990
Miami, Florida, United States
Local Institution - 010-922-F
Naples, Florida, United States
Local Institution - 010-922-G
Naples, Florida, United States
Local Institution - 010-538
Ocala, Florida, United States
Local Institution - 010-896
Orlando, Florida, United States
Local Institution - 010-988
Orlando, Florida, United States
Local Institution - 010-922-H
Port Charlotte, Florida, United States
Local Institution - 010-923
St. Petersburg, Florida, United States
Local Institution - 010-984
St. Petersburg, Florida, United States
Local Institution - 010-924
Tallahassee, Florida, United States
Local Institution - 010-984-A
Trinity, Florida, United States
Local Institution - 010-926
West Palm Beach, Florida, United States
Local Institution - 010-537
Weston, Florida, United States
Local Institution - 010-956
Atlanta, Georgia, United States
Local Institution - 010-986
Newnan, Georgia, United States
Local Institution - 010-963
Naperville, Illinois, United States
Local Institution - 010-994
Zion, Illinois, United States
Local Institution - 010-569-A
Indianapolis, Indiana, United States
Local Institution - 010-569
Indianapolis, Indiana, United States
Local Institution - 010-991
Iowa City, Iowa, United States
Local Institution - 010-920
Baton Rouge, Louisiana, United States
Local Institution - 010-534
Baltimore, Maryland, United States
Local Institution - 010-997
Boston, Massachusetts, United States
Local Institution - 010-531A
Brownstown, Michigan, United States
Local Institution - 010-531C
Dearborn, Michigan, United States
Local Institution - 010-531
Detroit, Michigan, United States
Local Institution - 010-531B
Novi, Michigan, United States
Local Institution - 010-875
Minneapolis, Minnesota, United States
Local Institution - 010-830
Rochester, Minnesota, United States
Local Institution - 010-838
Saint Louis Park, Minnesota, United States
Local Institution - 010-838A
Saint Louis Park, Minnesota, United States
Local Institution - 010-838B
Saint Louis Park, Minnesota, United States
Local Institution - 010-838C
Saint Louis Park, Minnesota, United States
Local Institution - 010-838D
Saint Louis Park, Minnesota, United States