Clinical Research Directory
Browse clinical research sites, groups, and studies.
Research Study on Whether Semaglutide Works in People With Non-alcoholic Steatohepatitis (NASH)
Sponsor: Novo Nordisk A/S
Summary
Semaglutide is a medicine studied in patients with NASH. Semaglutide is a well-known medicine, which is already used by doctors to treat type 2 diabetes in many countries. Participants will either get semaglutide or a dummy medicine - which treatment participants get is decided by chance. Participants will need to inject themselves with medicine under the skin. Participants will need to do this once a week. The study will last for about 5 years. Participants will have up to 21 clinic visits and 9 phone calls with the clinical staff during the study. Some of the clinic visits may be spread over more than one day. Participants with other chronic liver diseases cannot take part in this study. Women cannot take part in the study if they are pregnant, breast-feeding or plan to become pregnant during the study period.
Official title: The Effect of Semaglutide in Subjects With Non-cirrhotic Non-alcoholic Steatohepatitis
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
1205
Start Date
2021-04-01
Completion Date
2029-04-25
Last Updated
2026-10-13
Healthy Volunteers
No
Conditions
Interventions
Semaglutide
Semaglutide administrated subcutaneously (under the skin) once weekly there will be a period of dose escalation before reaching the target dose.
Placebo
Placebo administrated subcutaneously (under the skin) once weekly.
Locations (558)
North AL Health Res, LLC
Huntsville, Alabama, United States
The Institute for Liver Health
Chandler, Arizona, United States
Inst-Liver Hlth dba AZ Liver H
Peoria, Arizona, United States
Inst. Liver H II dba AZ Liver H
Tucson, Arizona, United States
Del Sol Research Management, LLC
Tucson, Arizona, United States
ARcare Center for Clinical Research
Jonesboro, Arkansas, United States
ARcare Center for Clinical Research
Little Rock, Arkansas, United States
Arkansas Diagnostic Center, PA
Little Rock, Arkansas, United States
Gastroenterology & Liver Institute
Escondido, California, United States
Shang Wu M.D. Inc.
Hacienda Heights, California, United States
Scripps Whittier Diabetes Inst
La Jolla, California, United States
UCSD NAFLD Research Center
La Jolla, California, United States
OM Research LLC
Lancaster, California, United States
Digestive Hlth Res of SoCa
Long Beach, California, United States
OM Research LLC
Oxnard, California, United States
Cedars-Sinai Medical Center
Pasadena, California, United States
Pasedena Liver Center
Pasadena, California, United States
Inland Empire Clin Trials LLC
Rialto, California, United States
UC Davis Hlth -Midtwn Ambu Cen
Sacramento, California, United States
University of California, San Francisco
San Francisco, California, United States
San Jose Gastroenterology
San Jose, California, United States
Peak Gastro Assoc-Col Springs
Colorado Springs, Colorado, United States
Yale Ctr for Clin Invest
New Haven, Connecticut, United States
Encore Medical Research of Boynton Beach LLC
Boynton Beach, Florida, United States
Integrity Clinical Research, LLC
Doral, Florida, United States
Covenant Metabolic Specialists, Ft. Myers
Fort Myers, Florida, United States
University of Florida-CTRB
Gainesville, Florida, United States
Miguel Rebollar PA
Hialeah, Florida, United States
Direct Helpers Research Center
Hialeah, Florida, United States
Florida Research Institute, LLC
Lakewood Rch, Florida, United States
Sandhill Research, LLC
Maitland, Florida, United States
Tandem Clinical Research - Maitland
Maitland, Florida, United States
Optimus U, Corp
Miami, Florida, United States
Univ of Miami/Schiff Ctr
Miami, Florida, United States
Genoma Research Group, Inc
Miami, Florida, United States
IMIC Inc
Miami, Florida, United States
San Marcus Res Clin Miami Lakes
Miami Lakes, Florida, United States
Ocala GI Research
Ocala, Florida, United States
Sensible Healthcare LLC
Ocoee, Florida, United States
Covenant Metabolic Specialists LLC
Sarasota, Florida, United States
Headlands Research - Sarasota
Sarasota, Florida, United States
Theia Clinical Research Centers LLC
St. Petersburg, Florida, United States
ClinCloud, LLC
Viera E., Florida, United States
Florida Medical Clinic Orlando Health
Zephyrhills, Florida, United States
Emory University Hospital
Atlanta, Georgia, United States
Columbus Regional Research Institute
Columbus, Georgia, United States
Gastroenterology Assoc_ CGA
Macon, Georgia, United States
Gastroint Spec of Georgia
Marietta, Georgia, United States
Rush University Med. Cntr
Chicago, Illinois, United States
University Of Chicago
Chicago, Illinois, United States
Endeavor Health
Skokie, Illinois, United States
Indiana University Hospital
Indianapolis, Indiana, United States
Digestive Research Alliance of Michiana
South Bend, Indiana, United States
Iowa Digestive Disease Center
Clive, Iowa, United States
University Of Kansas Hospital
Kansas City, Kansas, United States
Kansas Medical Clinic, PA
Topeka, Kansas, United States
Tandem Clinical Research - Houma
Houma, Louisiana, United States
Tandem Clinical Research
Marrero, Louisiana, United States
Tandem Clinical Research - Metairie
Metairie, Louisiana, United States
Louisiana Research Center, LLC
Shreveport, Louisiana, United States
Mercy Medical Center, GI Research
Baltimore, Maryland, United States
Walter Reed Nat Mil Md Ctr
Bethesda, Maryland, United States
Woodholme Gastroenterology Associates
Glen Burnie, Maryland, United States
Boston Medical Center_Cary
Boston, Massachusetts, United States
University of Michigan Medicine
Ann Arbor, Michigan, United States
Henry Ford Health System
Detroit, Michigan, United States
Mayo Clinic
Rochester, Minnesota, United States
Southern Therapy and Advanced Research LLC
Jackson, Mississippi, United States
Clinical Research Professionals
Chesterfield, Missouri, United States
Kansas City Research Institute
Kansas City, Missouri, United States
Univ of Nebraska Medical CTR
Omaha, Nebraska, United States
Jubilee Clinical Research, Inc.
Las Vegas, Nevada, United States
Sierra Clinical Research-Las Vegas
Las Vegas, Nevada, United States
AIG Digestive Disease Research
Florham Park, New Jersey, United States
Premier Health Research, LLC
Sparta, New Jersey, United States
NYU Grossman School of Med
New York, New York, United States
Weill Cornell Med Coll-NYPH
New York, New York, United States
Icahn Sch of Med-Mt Sinai Hosp
New York, New York, United States
AtriumHealth Liver Care, Pineville
Charlotte, North Carolina, United States
Northeast GI Research Division
Concord, North Carolina, United States
Duke Univ. Med CNTR_Durham_2
Durham, North Carolina, United States
Ohio State Univ Wexner Med Ctr
Columbus, Ohio, United States
Objective GI
Springboro, Ohio, United States
CRIOH
Westlake, Ohio, United States
Options Health Research, LLC
Tulsa, Oklahoma, United States
Geisinger Clinic
Danville, Pennsylvania, United States
Pennsylvania State University
Hershey, Pennsylvania, United States
Univ of Pennsylvania Hospital
Philadelphia, Pennsylvania, United States
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania, United States
UPMC Center for Liver Diseases
Pittsburgh, Pennsylvania, United States
UPMC_Center for Liver Care
Pittsburgh, Pennsylvania, United States
Care Access Research, Pottsville
Pottsville, Pennsylvania, United States
Clinical Res Collaborative
Cumberland, Rhode Island, United States
Ocean St Clin Res Partnrs, LLC
Lincoln, Rhode Island, United States
Medical University Of South Carolina
Charleston, South Carolina, United States
WR-ClinSearch, LLC
Chattanooga, Tennessee, United States
Digestive Health Res-TSMC
Hermitage, Tennessee, United States
East Tennessee Research Institute
Johnson City, Tennessee, United States
Quality Medical Research
Nashville, Tennessee, United States
Amarillo Center for Clinical Research, Ltd.
Amarillo, Texas, United States