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Savolitinib Plus Osimertinib Versus Platinum-based Doublet Chemotherapy in Participants With Non-Small Cell Lung Cancer Who Have Progressed on Osimertinib Treatment
Sponsor: AstraZeneca
Summary
Clinical study to investigate the efficacy and safety of savolitinib in combination with osimertinib versus platinum-based doublet chemotherapy in participants with EGFR mutated, MET-overexpressed and/or amplified, locally advanced or metastatic NSCLC who have progressed on treatment with Osimertinib.
Official title: A Phase III, Randomised, Open-Label Study of Savolitinib in Combination With Osimertinib Versus Platinum-Based Doublet Chemotherapy in Participants With EGFR Mutated, MET-Overexpressed and/or Amplified, Locally Advanced or Metastatic Non-Small Cell Lung Cancer Who Have Progressed on Treatment With Osimertinib (SAFFRON).
Key Details
Gender
All
Age Range
18 Years - 130 Years
Study Type
INTERVENTIONAL
Enrollment
341
Start Date
2022-08-03
Completion Date
2026-11-23
Last Updated
2026-08-06
Healthy Volunteers
No
Conditions
Interventions
Savolitinib
300 mg savolitinib (3 × 100 mg tablets twice daily) Administrative route : oral
Osimertinib
80 mg osimertinib (1 × 80 mg tablet once daily) Administrative route : oral
Pemetrexed
Pemetrexed (500 mg/m2) Administrative route : IV infusion
Cisplatin
Cisplatin (75 mg/m2) Administrative route : IV infusion
Carboplatin
Carboplatin (AUC5) Administrative route : IV infusion
Locations (214)
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Orlando, Florida, United States
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Honolulu, Hawaii, United States
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New Brunswick, New Jersey, United States
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New York, New York, United States
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Nashville, Tennessee, United States
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Buenos Aires, Argentina
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CABA, Argentina
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Florida, Argentina
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La Rioja, Argentina
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Rosario, Argentina
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Rosario, Argentina
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San Miguel de Tucumán, Argentina
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Viedma, Argentina
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Fremantle, Australia
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Southport, Australia
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Waratah NSW, Australia
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Westmead, Australia
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Brussels, Belgium
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Ghent, Belgium
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Roeselare, Belgium
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Belo Horizonte, Brazil
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Cachoeiro de Itapemirim, Brazil
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Ijuí, Brazil
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Porto Alegre, Brazil
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Porto Alegre, Brazil
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Salvador, Brazil
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Salvador, Brazil
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São Paulo, Brazil
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São Paulo, Brazil
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São Paulo, Brazil
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Vitória, Brazil
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Toronto, Ontario, Canada
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Toronto, Ontario, Canada
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Montreal, Quebec, Canada
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Montreal, Quebec, Canada
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Santiago, Chile
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Baoding, China
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Beijing, China
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Beijing, China
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Bengbu, China
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Changchun, China
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Changsha, China
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Changsha, China
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Chengdu, China
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Chongqing, China
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Fuzhou, China
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Fuzhou, China
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Hangzhou, China
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Harbin, China
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Hefei, China
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Jinan, China
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Linyi, China
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Nanchang, China
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Qingdao, China
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Shanghai, China
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Shenyang, China
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Shenzhen, China
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Wuhan, China
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Wuhan, China
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Xi'an, China
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Xi'an, China
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Xiangfan, China
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Yichang, China
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Zhengzhou, China
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Bobigny, France
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Brest, France
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Créteil, France
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Dijon, France
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Marseille, France
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Paris, France
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Poitiers, France
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Rennes, France
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Rouen, France
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Saint-Herblain, France
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Saint-Quentin, France
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Strasbourg, France
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Suresnes, France
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Berlin, Germany
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Chemnitz, Germany
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Frankfurt A. Main, Germany
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Gauting, Germany
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Immenhausen, Germany
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Löwenstein, Germany
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München, Germany
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Münster, Germany
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Wangen, Germany
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Athens, Greece
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Athens, Greece
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Chaïdári, Greece
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Heraklion, Greece
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Larissa, Greece
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Rio, Greece
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Thessaloniki, Greece
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Thessaloniki, Greece
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Hong Kong, Hong Kong
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Kowloon, Hong Kong
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Afula, Israel
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Ashdod, Israel
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Be’er Ya‘aqov, Israel
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Hadera, Israel