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Phase 2/3 Adaptive Study of VX-147 in Adult and Pediatric Participants With APOL1-Mediated Proteinuric Kidney Disease
Sponsor: Vertex Pharmaceuticals Incorporated
Summary
The purpose of this study is to evaluate the efficacy, safety, tolerability, and pharmacokinetics (PK) of VX-147 in adult and pediatric participants with apolipoprotein L1 (APOL1)-mediated proteinuric kidney disease.
Official title: A Phase 2/3 Adaptive, Double-blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of VX-147 in Adult and Pediatric Subjects With APOL1-mediated Proteinuric Kidney Disease
Key Details
Gender
All
Age Range
10 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
522
Start Date
2022-03-30
Completion Date
2030-05-07
Last Updated
2026-10-26
Healthy Volunteers
No
Conditions
Interventions
VX-147
Tablets for oral administration.
Placebo
Tablets for oral administration.
Locations (314)
Alabama Kidney Research
Alabaster, Alabama, United States
EmVenio Research - Mobile Unit - Birmingham
Birmingham, Alabama, United States
Cardiology, P.C.
Birmingham, Alabama, United States
Children's Hospital of Alabama
Birmingham, Alabama, United States
The Kirklin Clinic - Nephrology
Birmingham, Alabama, United States
Nephrology Associates
Fairhope, Alabama, United States
Heart Center Research LLC
Huntsville, Alabama, United States
Nephrology Consultants, LLC
Huntsville, Alabama, United States
Renal Associates of Alabama, LLC
Montgomery, Alabama, United States
Arizona Kidney Disease and Hypertension Center - Thomas Office
Phoenix, Arizona, United States
Phoenix Children's Hospital, Inc. - Nephrology
Phoenix, Arizona, United States
CHI St. Vincent Heart Clinic Arkansas- Cardiology and Medicine Clinic - Little Rock
Little Rock, Arkansas, United States
UAMS Medical Center - Pulmonology
Little Rock, Arkansas, United States
The Medical Research Group - Saint Agnes Medical Center
Fresno, California, United States
Amicis Research Center - Balboa
Granada Hills, California, United States
Kidney Care Center of North Valley
Granada Hills, California, United States
Eastside Clinical Research Associates
Los Angeles, California, United States
Kaiser Permanente Los Angeles Medical Center
Los Angeles, California, United States
Cedars-Sinai Medical Center
Los Angeles, California, United States
UCLA Division of Nephrology
Los Angeles, California, United States
UCI Center for Clinical Research
Orange, California, United States
Kaiser Permanente Sacramento Medical Center
Sacramento, California, United States
Helen Diller Medical Center at Parnassus Heights
San Francisco, California, United States
UCLA Lundquist Institute at Harbor-UCLA Medical Center
Torrance, California, United States
Kidney and Hypertension Center
Victorville, California, United States
Greater Hartford Nephrology
Bloomfield, Connecticut, United States
Nephrology & Hypertension Associates, PC
Middlebury, Connecticut, United States
Yale University - Yale Nephrology Clinical Research Clinic
New Haven, Connecticut, United States
Children's National Hospital - Nephrology
Washington D.C., District of Columbia, United States
The George Washington University - GW Medical Faculty Associates
Washington D.C., District of Columbia, United States
Veterans Affairs Medical Center - Washington D.C
Washington D.C., District of Columbia, United States
Bay Pines Foundation
Bay Pines, Florida, United States
Nova Clinical Research, LLC - Bradenton - 59th St
Bradenton, Florida, United States
Clinical Research of Brandon, LLC
Brandon, Florida, United States
AMR-Miami
Coral Gables, Florida, United States
Horizon Research Group - Coral Gables
Coral Gables, Florida, United States
South Florida Nephrology Research
Coral Springs, Florida, United States
Delray Physician Care Center
Delray Beach, Florida, United States
North Florida/South Georgia Veterans Health System
Gainesville, Florida, United States
Shands Hospital - Nephrology
Gainesville, Florida, United States
Velocity Clinical Research - Hallandale Beach
Hallandale, Florida, United States
Qway Research
Hialeah, Florida, United States
Elixia Pines
Hollywood, Florida, United States
UF Health Cardiovascular Center - Jacksonville
Jacksonville, Florida, United States
South Florida Research Institute
Lauderdale Lakes, Florida, United States
Total Research Group, LLC
Miami, Florida, United States
Cordova Research Institute
Miami, Florida, United States
South Florida Research
Miami Springs, Florida, United States
CTR Oakwater, LLC
Orlando, Florida, United States
Synexus Clinical Research - Orlando
Orlando, Florida, United States
Omega Research Orlando, LLC - Mercy Dr
Orlando, Florida, United States
Infigo Clinical Research
Sanford, Florida, United States
Genesis Clinical Research
Tampa, Florida, United States
Elixia Tampa
Tampa, Florida, United States
American Clinical Trials LLC - Acworth
Acworth, Georgia, United States
Kaiser Permanente Georgia
Atlanta, Georgia, United States
Emory School of Medicine - Renal Division
Atlanta, Georgia, United States
Advanced Clinical Research of Atlanta
Atlanta, Georgia, United States
Morehouse School of Medicine, Grady Memorial Hospital
Atlanta, Georgia, United States
Emory Childrens Center - Nephrology
Atlanta, Georgia, United States
Synexus Clinical Research - Atlanta (DRS)
Atlanta, Georgia, United States
Fides Clinical Research
Atlanta, Georgia, United States
Augusta University Medical College of Georgia - Adult Sickle Cell Clinic
Augusta, Georgia, United States
Coastal Medical Research
Brunswick, Georgia, United States
Randomize Now - College Park
College Park, Georgia, United States
Clincept - Veterans Pkwy.
Columbus, Georgia, United States
Renal Associates
Columbus, Georgia, United States
Georgia Nephrology - Decatur
Decatur, Georgia, United States
Atlanta VA Healthcare System
Decatur, Georgia, United States
American Clinical Trials LLC - Douglasville
Douglasville, Georgia, United States
Southeast Kidney Associates
East Point, Georgia, United States
Javara Inc./Privia Medical Group - Fayetteville, GA
Fayetteville, Georgia, United States
Georgia Nephrology - Lawrenceville - Billing Office
Lawrenceville, Georgia, United States
Javara Inc./Privia Medical Group - Savannah, GA
Savannah, Georgia, United States
Inova Clinical Trials and Research Center
Tyrone, Georgia, United States
Rophe Adult and Pediatric Medicine
Union City, Georgia, United States
Synexus Clinical Research - Chicago (DRS)
Chicago, Illinois, United States
EmVenio Research - Chicago
Chicago, Illinois, United States
Ann & Robert H. Lurie Children's Hospital of Chicago - Nephrology
Chicago, Illinois, United States
Northwestern Medical Group
Chicago, Illinois, United States
UChicago Medicine - Comer Children's Hospital
Chicago, Illinois, United States
NANI Research LLC - Evergreen Park IL
Evergreen Park, Illinois, United States
Edward Hines Jr VA Hospital
Hines, Illinois, United States
Essential Concepts Research Solutions
Palos Hills, Illinois, United States
NANI Research LLC - Fort Wayne IN
Fort Wayne, Indiana, United States
IU School of Medicine - Nephrology
Indianapolis, Indiana, United States
Nephrology Physicians, LLC
Mishawaka, Indiana, United States
University of Iowa Health Care Medical Center- Nephrology
Iowa City, Iowa, United States
Clinical & Translational Science Unit (CTSU) - Nephrology
Kansas City, Kansas, United States
Premier Clinical Research
Overland Park, Kansas, United States
Renal Associates of Baton Rouge
Baton Rouge, Louisiana, United States
LCMC Health
Metairie, Louisiana, United States
Barnum Medical Research - Bienville St
Natchitoches, Louisiana, United States
Louisiana Clinical and Translational Science (LA CaTS) Center
New Orleans, Louisiana, United States
University Medical Center - New Orleans - Nephrology
New Orleans, Louisiana, United States
Ochsner Medical Center - New Orleans
New Orleans, Louisiana, United States
Northwest Louisiana Nephrology, LLC
Shreveport, Louisiana, United States
Louisiana State University Health Shreveport
Shreveport, Louisiana, United States
Monroe Research, LLC
West Monroe, Louisiana, United States
Javara Inc./Privia Medical Group - Annapolis, MD
Annapolis, Maryland, United States