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Mirvetuximab Soravtansine With Bevacizumab Versus Bevacizumab as Maintenance in Platinum-sensitive Epithelial Ovarian, Fallopian Tube, or Peritoneal Cancer
Sponsor: AbbVie
Summary
GLORIOSA is a Phase 3 multicenter, open label study designed to evaluate the safety and efficacy of mirvetuximab Soravtansine + Bevacizumab as maintenance therapy in participants with platinum-sensitive ovarian, primary peritoneal or fallopian tube cancers with high folate receptor-alpha (FRα) expression.
Official title: Randomized, Multicenter, Open-label, Phase 3 Study of Mirvetuximab Soravtansine in Combination With Bevacizumab Versus Bevacizumab Alone as Maintenance Therapy for Patients With FRα-high Recurrent Platinum-sensitive Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancers Who Have Not Progressed After Second Line Platinum-based Chemotherapy Plus Bevacizumab
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
520
Start Date
2023-03-15
Completion Date
2032-05
Last Updated
2026-06-02
Healthy Volunteers
No
Interventions
Mirvetuximab soravtansine plus Bevacizumab
Participants will receive MIRV 6.0 mg/kg adjusted ideal body weight (AIBW) plus Bevacizumab 15mg/kg every 3 weeks
Bevacizumab
Participants will receive Bevacizumab 15mg/kg every 3 weeks
Locations (264)
Usa Mitchell Cancer Institute /ID# 269661
Mobile, Alabama, United States
Honorhealth Virginia G. Piper Cancer Care Network - Biltmore /ID# 269987
Phoenix, Arizona, United States
City of Hope - Orange County Lennar Foundation Cancer Center /ID# 269573
Irvine, California, United States
Moores Cancer Center at UC San Diego /ID# 269564
La Jolla, California, United States
Kaiser Permanente - Los Angeles Medical Center /ID# 269541
Los Angeles, California, United States
University Of California Irvine Medical Center /ID# 269572
Orange, California, United States
Stanford Women'S Cancer Center /ID# 269552
Palo Alto, California, United States
Kaiser Permanente - Riverside Medical Center /ID# 269539
Riverside, California, United States
Kaiser Permanente Zion Medical Center /ID# 269537
San Diego, California, United States
Kaiser Permanente - San Diego Medical Center /ID# 269540
San Diego, California, United States
Kaiser Permanente - San Marcos Medical Offices /ID# 269542
San Marcos, California, United States
Olive View-Ucla Medical Center /ID# 269584
Sylmar, California, United States
John Muir Health - Walnut Creek Medical Center /ID# 269575
Walnut Creek, California, United States
Broward General Medical Center /ID# 269577
Fort Lauderdale, Florida, United States
Regional Cancer Center /ID# 269558
Fort Myers, Florida, United States
Baptist Md Anderson Cancer Center - Jacksonville - Palm Avenue /ID# 269560
Jacksonville, Florida, United States
Mount Sinai Medical Center /ID# 269582
Miami, Florida, United States
Sarasota Memorial Hospital /ID# 269526
Sarasota, Florida, United States
Northside Hospital /ID# 269660
Atlanta, Georgia, United States
Rush University Medical Center /ID# 269583
Chicago, Illinois, United States
University of Chicago Medical Center /ID# 269546
Chicago, Illinois, United States
Indiana University Melvin and Bren Simon Comprehensive Cancer Center /ID# 269110
Indianapolis, Indiana, United States
St. Vincent Indianapolis Hospital /ID# 269107
Indianapolis, Indiana, United States
University of Iowa /ID# 269566
Iowa City, Iowa, United States
The University of Kansas Cancer Center - Westwood /ID# 269106
Westwood, Kansas, United States
Baptist Health Lexington /ID# 269568
Lexington, Kentucky, United States
University of Kentucky Chandler Medical Center. /ID# 269536
Lexington, Kentucky, United States
Louisiana State University Health Sciences Center - New Orleans /ID# 269559
New Orleans, Louisiana, United States
Ochsner Medical Center - Jefferson Highway /ID# 269530
New Orleans, Louisiana, United States
Maine Medical Center - Scarborough Campus /ID# 269555
Scarborough, Maine, United States
Johns Hopkins Hospital /ID# 269579
Baltimore, Maryland, United States
Sinai Hospital Of Baltimore /ID# 269567
Manchester, Maryland, United States
GBMC Cancer Center /ID# 269561
Towson, Maryland, United States
Tufts Medical Center /ID# 269547
Boston, Massachusetts, United States
Baystate Medical Center /ID# 269544
Springfield, Massachusetts, United States
Corewell Health /ID# 269562
Grand Rapids, Michigan, United States
Minnesota Oncology - Coon Rapids Clinic /ID# 269550
Coon Rapids, Minnesota, United States
Nebraska Methodist Hospital /ID# 269580
Omaha, Nebraska, United States
The Center Of Hope /ID# 269528
Reno, Nevada, United States
Dartmouth-Hitchcock Medical Center /ID# 269576
Lebanon, New Hampshire, United States
John Theurer Cancer Center /ID# 269109
Hackensack, New Jersey, United States
The Valley Hospital /ID# 269548
Paramus, New Jersey, United States
Holy Name Medical Center /ID# 269543
Teaneck, New Jersey, United States
New York Oncology Hematology - Albany Cancer Center /ID# 269565
Albany, New York, United States
Women'S Cancer Care Associates /ID# 269553
Albany, New York, United States
Northwell Health Center for Advanced Medicine. /ID# 269108
Lake Success, New York, United States
Perlmutter Cancer Center at NYU Langone Hematology Oncology Associates - Mineola /ID# 269534
Mineola, New York, United States
NYU Laura and Isaac Perlmutter Cancer Center /ID# 269556
New York, New York, United States
Icahn School of Medicine at Mount Sinai /ID# 269529
New York, New York, United States
University of North Carolina at Chapel Hill /ID# 269563
Chapel Hill, North Carolina, United States
Duke Cancer Institute /ID# 269557
Durham, North Carolina, United States
University of Cincinnati /ID# 269578
Cincinnati, Ohio, United States
Jamescare Gynecologic Oncology At Mill Run /ID# 269105
Hilliard, Ohio, United States
Kettering Medical Center /ID# 269585
Kettering, Ohio, United States
OU Health - Stephenson Cancer Center /ID# 269525
Oklahoma City, Oklahoma, United States
Oklahoma Cancer Specialists and Research Institute /ID# 269527
Tulsa, Oklahoma, United States
Willamette Valley Cancer Institute and Research Center /ID# 269988
Eugene, Oregon, United States
Compass Oncology - Rose Quarter /ID# 270131
Portland, Oregon, United States
Oregon Health and Science University /ID# 269581
Portland, Oregon, United States
University Of Pittsburgh Medical Center Magee - Womens Hospital /ID# 269659
Pittsburgh, Pennsylvania, United States
Allegheny Health Network West Penn Hospital /ID# 269551
Pittsburgh, Pennsylvania, United States
Asplundh Cancer Pavilion /ID# 269574
Willow Grove, Pennsylvania, United States
Sanford Cancer Center /ID# 269535
Sioux Falls, South Dakota, United States
West Cancer Center and Research Institute - Germantown /ID# 269569
Germantown, Tennessee, United States
Texas Oncology - Austin Central /ID# 269531
Austin, Texas, United States
Texas Oncology - Bedford /ID# 269571
Bedford, Texas, United States
Texas Oncology - Methodist Dallas Cancer Center /ID# 269554
Dallas, Texas, United States
Texas Oncology - Fort Worth Cancer Center /ID# 269532
Fort Worth, Texas, United States
US Oncology Research Investigational Products Center /ID# 278746
Irving, Texas, United States
Texas Oncology - San Antonio Medical Center - Research Drive /ID# 269549
San Antonio, Texas, United States
University of Virginia Health System /ID# 269545
Charlottesville, Virginia, United States
Virginia Oncology Associates - Norfolk (Lake Wright) /ID# 269533
Norfolk, Virginia, United States
VCU Health Adult Outpatient Pavillion /ID# 269570
Richmond, Virginia, United States
Swedish Cancer Institute /ID# 269538
Seattle, Washington, United States
Sanatorio De La Mujer /ID# 269352
Rosario, Santa Fe Province, Argentina
Hospital Italiano de Buenos Aires /ID# 269356
Buenos Aires, Argentina
Hospital Italiano de Córdoba (Sociedad de Beneficencia Hospital Italiano) /ID# 269090
Córdoba, Argentina
Isis Centro Especializado De Luce /ID# 269353
Santa Fe, Argentina
Westmead Hospital /ID# 269362
Westmead, New South Wales, Australia
Gold Coast University Hospital /ID# 269365
Southport, Queensland, Australia
Ballarat Base Hospital /ID# 269364
Ballarat, Victoria, Australia
Monash Health - Monash Medical Centre /ID# 269360
Clayton, Victoria, Australia
Cabrini Hospital Malvern /ID# 269359
Malvern, Victoria, Australia
Peter MacCallum Cancer Centre /ID# 269361
Melbourne, Victoria, Australia
Epworth Hospital /ID# 269363
Richmond, Victoria, Australia
St. John Of God Subiaco Hospital /ID# 269358
Subiaco, Western Australia, Australia
Imelda Ziekenhuis /ID# 269369
Bonheiden, Antwerpen, Belgium
Cliniques Universitaires UCL Saint-Luc /ID# 269368
Brussels, Brussels Capital, Belgium
Grand Hôpital De Charleroi - Notre Dame /ID# 269367
Charleroi, Hainaut, Belgium
AZ Sint-Lucas /ID# 269366
Ghent, Oost-Vlaanderen, Belgium
Universitair Ziekenhuis Leuven /ID# 269370
Leuven, Vlaams-Brabant, Belgium
AZ-Delta. /ID# 269091
Roeselare, West-Vlaanderen, Belgium
UCL Namur University Hospital, Site Sainte-Elisabeth /ID# 269371
Namur, Belgium
Hospital Santa Izabel /ID# 269384
Salvador, Estado de Bahia, Brazil
Catarina Pesquisa Clinica /ID# 269379
Itajaí, Santa Catarina, Brazil
Beneficência Portuguesa de São Paulo /ID# 269092
São Paulo, São Paulo, Brazil
Hospital Nove De Julho /ID# 269375
São Paulo, São Paulo, Brazil
Complex Oncology Center - Shumen /ID# 269372
Shumen, Bulgaria
Comprehensive Cancer Center /ID# 269373
Vratsa, Bulgaria
Arthur J.E Child Comprehensive Cancer Centre /ID# 269388
Calgary, Alberta, Canada