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A Study Comparing Talquetamab in Combination With Daratumumab or in Combination With Daratumumab and Pomalidomide Versus Daratumumab in Combination With Pomalidomide and Dexamethasone in Participants With Multiple Myeloma That Returns After Treatment or is Resistant to Treatment
Sponsor: Janssen Research & Development, LLC
Summary
The purpose of the study is to compare the efficacy of talquetamab subcutaneous(ly) (SC) in combination with daratumumab SC and pomalidomide (Tal-DP) and talquetamab SC in combination with daratumumab SC (Tal-D), respectively, with daratumumab SC in combination with pomalidomide and dexamethasone (DPd).
Official title: A Phase 3 Randomized Study Comparing Talquetamab SC in Combination With Daratumumab SC and Pomalidomide (Tal-DP) or Talquetamab SC in Combination With Daratumumab SC (Tal-D) Versus Daratumumab SC, Pomalidomide and Dexamethasone (DPd), in Participants With Relapsed or Refractory Multiple Myeloma Who Have Received at Least 1 Prior Line of Therapy
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
864
Start Date
2022-10-13
Completion Date
2028-05-25
Last Updated
2026-11-03
Healthy Volunteers
No
Conditions
Interventions
Talquetamab
Talquetamab will be administered subcutaneously.
Daratumumab
Daratumumab will be administered subcutaneously.
Pomalidomide
Pomalidomide will be administered orally.
Dexamethasone
Dexamethasone will be administered orally or intravenously.
Locations (216)
The University of Arizona Cancer Center
Tucson, Arizona, United States
University of Arkansas for Medical Sciences
Little Rock, Arkansas, United States
Norwalk Hospital-oncology
Norwalk, Connecticut, United States
MedStar Georgetown University Hospital
Washington D.C., District of Columbia, United States
George Washington University
Washington D.C., District of Columbia, United States
Memorial Healthcare System
Hollywood, Florida, United States
University of Miami Health System
Miami, Florida, United States
University Of Illinois
Chicago, Illinois, United States
University of Kansas
Westwood, Kansas, United States
Tulane University Hospital & Clinics
New Orleans, Louisiana, United States
Ochsner Health System
New Orleans, Louisiana, United States
Johns Hopkins University
Baltimore, Maryland, United States
Massachusetts General
Boston, Massachusetts, United States
Boston University Medical Center
Boston, Massachusetts, United States
University of Massachusetts Medical School
Worcester, Massachusetts, United States
University of Michigan Health System
Ann Arbor, Michigan, United States
University Of Minnesota
Minneapolis, Minnesota, United States
University of Mississippi Medical Center
Jackson, Mississippi, United States
Washington University School Of Medicine
St Louis, Missouri, United States
Rutgers Cancer Institute of New Jersey
New Brunswick, New Jersey, United States
NYU Langone Health
New York, New York, United States
SUNY Upstate Medical University
Syracuse, New York, United States
University of North Carolina
Chapel Hill, North Carolina, United States
Levine Cancer Institute, Carolinas HealthCare System
Charlotte, North Carolina, United States
Novant Health 1
Charlotte, North Carolina, United States
Novant Health
Winston-Salem, North Carolina, United States
Wake Forest Baptist Medical Center
Winston-Salem, North Carolina, United States
University Hospitals Cleveland Medical Center
Cleveland, Ohio, United States
The Ohio State University Wexner Medical Center - James Cancer Hospital
Columbus, Ohio, United States
OhioHealth
Columbus, Ohio, United States
Thomas Jefferson University
Philadelphia, Pennsylvania, United States
Medical University of South Carolina
Charleston, South Carolina, United States
Baptist Cancer Center
Memphis, Tennessee, United States
Houston Methodist Hospital
Houston, Texas, United States
MD Anderson Cancer Center
Houston, Texas, United States
Joe Arrington Cancer Research Treatment Center
Lubbock, Texas, United States
Huntsman Cancer Institute
Salt Lake City, Utah, United States
University of Virginia
Charlottesville, Virginia, United States
Virginia Commonwealth University - Massey Cancer Center
Richmond, Virginia, United States
Fred Hutchinson Cancer Research Center
Seattle, Washington, United States
UZ Brussel
Brussels, Belgium
UZA
Edegem, Belgium
Virga Jessa Ziekenhuis
Hasselt, Belgium
CHC MontLegia
Liège, Belgium
Clinique Saint Pierre
Ottignies, Belgium
UCL Mont Godinne
Yvoir, Belgium
Fundacao Pio XII
Barretos, Brazil
Santa Casa de Misericordia de Belo Horizonte
Belo Horizonte, Brazil
IDOR - Regional Brasilia
Brasília, Brazil
Fundacao Universidade de Caxias do Sul
Caxias do Sul, Brazil
Hospital Erasto Gaertner- Liga Paranaense de Combate ao Cancer
Curitiba, Brazil
Grupo ELORA Centro de Pesquisa e Ensino em Saude de Santa Catarina
Florianópolis, Brazil
Liga Norte Riograndense Contra O Cancer
Natal, Brazil
Irmandade Santa Casa de Misericordia de Porto Alegre
Porto Alegre, Brazil
Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto
Ribeirão Preto, Brazil
Instituto de Educacao, Pesquisa e Gestao em Saude Instituto Americas (COI)
Rio de Janeiro, Brazil
IDOR - Regional Bahia
Salvador, Brazil
Sociedade Beneficente de Senhoras Hospital Sirio Libanes
São Paulo, Brazil
Real e Benemerita Associacao Portuguesa de Beneficencia
São Paulo, Brazil
Hospital Paulistano
São Paulo, Brazil
IDOR - Regional Sao Paulo
São Paulo, Brazil
Fundacao Antonio Prudente A C Camargo Cancer Center
São Paulo, Brazil
Clinica Medica Sao Germano LTDA
São Paulo, Brazil
Peking Union Medical College Hospital
Beijing, China
Peking University First Hospital
Beijing, China
The First Hospital of Jilin University
Changchun, China
The second Xiangya Hospital of Central South University
Changsha, China
Beijing Chaoyang Hospital
Chaoyang District, China
Sichuan Academy of Medical Science Sichuan Provincial Peoples Hospital
Chengdu, China
Fujian Medical University Union Hospital
Fuzhou, China
Guangdong Provincial People's Hospital
Guangzhou, China
Sun Yat Sen University Cancer Center
Guangzhou, China
The First Affiliated Hospital Zhejiang University College of Medicine
Hangzhou, China
Nanjing Drum Tower Hospital
Nanjing, China
Tongji Hospital of Tongji University
Shanghai, China
Shanghai Fourth People s Hospital
Shanghai, China
Peking University Shenzhen Hospital
Shenzhen, China
First Affiliated Hospital SooChow University
Suzhou, China
Tianjin cancer hospital
Tianjin, China
Institute of Hematology & Blood Disease Hospital Chinese Academy of Medical Science
Tianjin, China
Tongji Hospital, Tongji Medical College of HUST
Wuhan, China
Henan Cancer Hospital
Zhengzhou, China
Fakultni nemocnice Brno
Brno, Czechia
Fakultni nemocnice Hradec Kralove
Hradec Králové, Czechia
Fakultni nemocnice Olomouc
Olomouc, Czechia
Fakultni Nemocnice Ostrava
Ostrava - Poruba, Czechia
Fakultni nemocnice Kralovske Vinohrady
Prague, Czechia
Vseobecna fakultni nemocnice v Praze - I. interni klinika - klinika hematologie
Prague, Czechia
APHP - Hopital Henri Mondor
Créteil, France
CHU Dijon
Dijon, France
Centre Leon Berard
Lyon, France
CHU de Montpellier - Hopital Saint-Eloi
Montpellier, France
CHU de Nantes hotel Dieu
Nantes, France
CHU HOPITAL DE L'ARCHET - Hematology
Nice, France
CHU Hopital Saint Antoine
Paris, France
CHRU - Hôpital du Haut Lévêque - Centre François Magendie
Pessac, France
Institut Universitaire du cancer de Toulouse-Oncopole
Toulouse, France
Charite Campus Benjamin Franklin
Berlin, Germany
Universitaetsklinikum Koeln
Cologne, Germany
Asklepios Klinik Altona
Hamburg, Germany