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A Study to Evaluate Mezigdomide, Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)
Sponsor: Celgene
Summary
The purpose of this study is to compare the efficacy and safety of mezigdomide (CC-92480), bortezomib and dexamethasone (MeziVd) versus pomalidomide, bortezomib and dexamethasone (PVd) in participants with relapsed or refractory multiple myeloma (RRMM) who received between 1 to 3 prior lines of therapy and who have had prior lenalidomide exposure.
Official title: A Phase 3, Two-Stage, Randomized, Multicenter, Open-Label Study Comparing Mezigdomide (CC-92480), Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Subjects With Relapsed or Refractory Multiple Myeloma (RRMM): SUCCESSOR-1
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
810
Start Date
2022-09-20
Completion Date
2033-11-30
Last Updated
2026-10-30
Healthy Volunteers
No
Conditions
Interventions
mezigdomide
Specified dose on specified days
Pomalidomide
Specified dose on specified days
Bortezomib
Specified dose on specified days
Dexamethasone
Specified dose on specified days
Locations (266)
Local Institution - 0366
Los Alamitos, California, United States
Local Institution - 0272
San Diego, California, United States
Local Institution - 0273
West Hollywood, California, United States
Local Institution - 0381
Aurora, Colorado, United States
Local Institution - 0380
Farmington, Connecticut, United States
Local Institution - 0208
New Haven, Connecticut, United States
Local Institution - 0303
Coral Springs, Florida, United States
Local Institution - 0403
Fort Myers, Florida, United States
Local Institution - 0401
Orange City, Florida, United States
Local Institution - 0402
West Palm Beach, Florida, United States
Local Institution - 0211
Athens, Georgia, United States
Local Institution - 0048
Marietta, Georgia, United States
Local Institution - 0330
Garden City, Kansas, United States
Local Institution - 0080
Westwood, Kansas, United States
Local Institution - 0358
Baton Rouge, Louisiana, United States
Local Institution - 0255
New Orleans, Louisiana, United States
Local Institution - 0385
Shreveport, Louisiana, United States
Local Institution - 0357
Baltimore, Maryland, United States
Local Institution - 0246
Boston, Massachusetts, United States
Local Institution - 0271
Ann Arbor, Michigan, United States
Local Institution - 0364
Detroit, Michigan, United States
Local Institution - 0410
Minneapolis, Minnesota, United States
Local Institution - 0088
Hattiesburg, Mississippi, United States
Local Institution - 0242
Jackson, Mississippi, United States
Local Institution - 0288
East Brunswick, New Jersey, United States
Local Institution - 0363
Ridgewood, New Jersey, United States
Local Institution - 0302
Albuquerque, New Mexico, United States
Local Institution - 0245
Buffalo, New York, United States
Local Institution - 0257
Lake Success, New York, United States
Local Institution - 0373
New Hyde Park, New York, United States
Local Institution - 0371
New York, New York, United States
Local Institution - 0108
Rochester, New York, United States
Local Institution - 0374
Shirley, New York, United States
Local Institution - 0372
The Bronx, New York, United States
Local Institution - 0274
Williamsville, New York, United States
Local Institution - 0260
Durham, North Carolina, United States
Local Institution - 0400
Cincinnati, Ohio, United States
Local Institution - 0377
Cleveland, Ohio, United States
Local Institution - 0076
Cleveland, Ohio, United States
Local Institution - 0376
Mayfield Heights, Ohio, United States
Local Institution - 0359
Allentown, Pennsylvania, United States
Local Institution - 0264
York, Pennsylvania, United States
Local Institution - 0223
Germantown, Tennessee, United States
Local Institution - 0378
Abilene, Texas, United States
Local Institution - 0275
Houston, Texas, United States
Local Institution - 0267
San Antonio, Texas, United States
Local Institution - 0409
San Antonio, Texas, United States
Local Institution - 0207
Salt Lake City, Utah, United States
Local Institution - 0297
Fredericksburg, Virginia, United States
Local Institution - 0408
Norfolk, Virginia, United States
Local Institution - 0399
Roanoke, Virginia, United States
Local Institution - 0268
Seattle, Washington, United States
Local Institution - 0293
Seattle, Washington, United States
Local Institution - 0097
Spokane, Washington, United States
Local Institution - 0411
Vancouver, Washington, United States
Local Institution - 0220
Madison, Wisconsin, United States
Local Institution - 0318
Chivilcoy, Buenos Aires, Argentina
Local Institution - 0213
Buenos Aires, Buenos Aires F.D., Argentina
Local Institution - 0249
Córdoba, Córdoba Province, Argentina
Local Institution - 0239
Viedma, R, Argentina
Local Institution - 0200
Rosario, Santa Fe Province, Argentina
Local Institution - 0248
S3000epv, Santa Fe Province, Argentina
Local Institution - 0214
Buenos Aires, Argentina
Local Institution - 0055
Liverpool, New South Wales, Australia
Local Institution - 0004
Waratah, New South Wales, Australia
Local Institution - 0017
Wollongong, New South Wales, Australia
Local Institution - 0327
Birtinya, Queensland, Australia
Local Institution - 0221
Box Hill, Victoria, Australia
Local Institution - 0003
Melbourne, Victoria, Australia
Local Institution - 0002
Melbourne, Victoria, Australia
Local Institution - 0040
Nedlands, Western Australia, Australia
Local Institution - 0012
Vienna, State of Vienna, Austria
Local Institution - 0008
Krems, Austria
Local Institution - 0024
Leoben, Austria
Local Institution - 0011
Sankt Pölten, Austria
Local Institution - 0025
Vienna, Austria
Local Institution - 0138
Genk, Limburg, Belgium
Local Institution - 0206
Ghent, Oost-Vlaanderen, Belgium
Local Institution - 0179
Sint-Niklaas, Oost-Vlaanderen, Belgium
Local Institution - 0136
Antwerp, Belgium
Local Institution - 0046
Salvador, Estado de Bahia, Brazil
Local Institution - 0044
Porto Alegre, Rio Grande do Sul, Brazil
Local Institution - 0314
Joinville, Santa Catarina, Brazil
Local Institution - 0305
Jaú, São Paulo, Brazil
Local Institution - 0049
Rio de Janeiro, Brazil
Local Institution - 0050
São Paulo, Brazil
Local Institution - 0045
São Paulo, Brazil
Local Institution - 0225
Greenfield Park, Quebec, Canada
Local Institution - 0174
Montreal, Quebec, Canada
Local Institution - 0222
Québec, Quebec, Canada
Local Institution - 0329
Santiago, Santiago Metropolitan, Chile
Local Institution - 0387
Santiago, Santiago Metropolitan, Chile
Local Institution - 0332
Viña del Mar, Valparaiso, Chile
Local Institution - 0062
Beijing, Beijing Municipality, China
Local Institution - 0165
Beijing, Beijing Municipality, China
Local Institution - 0141
Beijing, Beijing Municipality, China
Local Institution - 0144
Chongqing, Chongqing Municipality, China
Local Institution - 0237
Xiamen, Fujian, China
Local Institution - 0117
Guangzhou, Guangdong, China
Local Institution - 0177
Guangzhou, Guangdong, China