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A Study to Evaluate Mezigdomide in Combination With Carfilzomib and Dexamethasone (MeziKD) Versus Carfilzomib and Dexamethasone (Kd) in Participants With Relapsed or Refractory Multiple Myeloma (SUCCESSOR-2)
Sponsor: Bristol-Myers Squibb
Summary
The purpose of the study is to compare Mezigdomide (CC-92480/BMS-986348) with carfilzomib and dexamethasone (MeziKD) against carfilzomib and dexamethasone (Kd) in the treatment of RRMM: SUCCESSOR-2.
Official title: A Phase 3, Two-stage, Randomized, Multicenter, Open-label Study Comparing Mezigdomide (CC-92480/BMS-986348), Carfilzomib, and Dexamethasone (MeziKD) Versus Carfilzomib and Dexamethasone (Kd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM): SUCCESSOR-2
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
606
Start Date
2023-01-10
Completion Date
2029-07-25
Last Updated
2026-09-24
Healthy Volunteers
No
Conditions
Interventions
Mezigdomide
Specified dose on specified days
Carfilzomib
Specified dose on specified days
Dexamethasone
Specified dose on specified days
Locations (204)
Local Institution - 0046
Mobile, Alabama, United States
Local Institution - 0005
Cerritos, California, United States
Local Institution - 0190
Irvine, California, United States
Local Institution - 0187
Los Angeles, California, United States
Local Institution - 0344
Santa Rosa, California, United States
Local Institution - 0339
Stockton, California, United States
Local Institution - 0341
Fort Myers, Florida, United States
Local Institution - 0342
St. Petersburg, Florida, United States
Local Institution - 0340
West Palm Beach, Florida, United States
Local Institution - 0348
Atlanta, Georgia, United States
Local Institution - 0291
Atlanta, Georgia, United States
Saint Alphonsus Regional Medical Center
Boise, Idaho, United States
Local Institution - 0289
Annapolis, Maryland, United States
Local Institution - 0204
Boston, Massachusetts, United States
Local Institution - 0346
Minneapolis, Minnesota, United States
Local Institution - 0222
Little Silver, New Jersey, United States
Local Institution - 0199
The Bronx, New York, United States
Local Institution - 0322
Cleveland, Ohio, United States
Local Institution - 0172
Columbus, Ohio, United States
Local Institution - 0321
Providence, Rhode Island, United States
Local Institution - 0338
Greer, South Carolina, United States
Local Institution - 0349
Chattanooga, Tennessee, United States
Local Institution - 0323
Nashville, Tennessee, United States
Local Institution - 0337
Fort Worth, Texas, United States
Local Institution - 0328
Houston, Texas, United States
Local Institution - 0044
Houston, Texas, United States
Local Institution - 0195
Temple, Texas, United States
Local Institution - 0345
Norfolk, Virginia, United States
Local Institution - 0343
Roanoke, Virginia, United States
Local Institution - 0006
Tacoma, Washington, United States
Local Institution - 0347
Vancouver, Washington, United States
Local Institution - 0243
Morgantown, West Virginia, United States
Local Institution - 0336
Marshfield, Wisconsin, United States
Local Institution - 0008
Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina
Local Institution - 0079
ABB, Buenos Aires F.D., Argentina
Local Institution - 0182
Rosario, Santa Fe Province, Argentina
Local Institution - 0319
San Miguel de Tucumán, Tucumán Province, Argentina
Local Institution - 0150
Buenos Aires, Argentina
Local Institution - 0151
Córdoba, Argentina
Local Institution - 0077
Camperdown, New South Wales, Australia
Local Institution - 0160
Gosford, New South Wales, Australia
Local Institution - 0263
Port Macquarie, New South Wales, Australia
Local Institution - 0078
St Leonards, New South Wales, Australia
Local Institution - 0026
Sydney, New South Wales, Australia
Local Institution - 0024
Adelaide, South Australia, Australia
Local Institution - 0131
Bendigo, Victoria, Australia
Local Institution - 0224
East Melbourne, Victoria, Australia
Local Institution - 0127
Heidelberg, Victoria, Australia
Local Institution - 0025
Melbourne, Victoria, Australia
Local Institution - 0266
Vienna, State of Vienna, Austria
Local Institution - 0020
Linz, Austria
Local Institution - 0017
Vienna, Austria
Local Institution - 0121
Salvador, Estado de Bahia, Brazil
Local Institution - 0076
Porto Alegre, Rio Grande do Sul, Brazil
Local Institution - 0085
São Paulo, São Paulo, Brazil
Local Institution - 0075
Rio de Janeiro, Brazil
Local Institution - 0073
São Paulo, Brazil
Local Institution - 0305
Plovdiv, Bulgaria
Local Institution - 0309
Sofia, Bulgaria
Local Institution - 0304
Sofia, Bulgaria
Local Institution - 0183
Halifax, Nova Scotia, Canada
Local Institution - 0275
London, Ontario, Canada
Local Institution - 0184
Toronto, Ontario, Canada
Local Institution - 0061
Beijing, Beijing Municipality, China
Local Institution - 0057
Beijing, Beijing Municipality, China
Local Institution - 0056
Beijing, Beijing Municipality, China
Local Institution - 0123
Fuzhou, Fujian, China
Local Institution - 0138
Guangzhou, Guangdong, China
Local Institution - 0051
Zhengzhou, Henan, China
Local Institution - 0066
Wuhan, Hubei, China
Local Institution - 0054
Wuhan, Hubei, China
Local Institution - 0071
Changsha, Hunan, China
Local Institution - 0103
Changsha, Hunan, China
Local Institution - 0180
Nanjing, Jiangsu, China
Local Institution - 0111
Nantong, Jiangsu, China
Local Institution - 0104
Suzhou, Jiangsu, China
Local Institution - 0069
Wuxi, Jiangsu, China
Local Institution - 0095
Nanchang, Jiangxi, China
Local Institution - 0052
Changchun, Jilin, China
Local Institution - 0096
Shenyang, Liaoning, China
Local Institution - 0176
Shenyang, Liaoning, China
Local Institution - 0060
Xi'an, Shaanxi, China
Local Institution - 0072
Jinan, Shandong, China
Local Institution - 0118
Shanghai, Shanghai Municipality, China
Local Institution - 0317
Shanghai, Shanghai Municipality, China
Local Institution - 0091
Tianjin, Tianjin Municipality, China
Local Institution - 0058
Kunming, Yunnan, China
Local Institution - 0050
Hangzhou, Zhejiang, China
Local Institution - 0115
Wenzhou, Zhejiang, China
Local Institution - 0059
Taiyuan, China
Local Institution - 0153
Medellín, Antioquia, Colombia
Local Institution - 0156
Valledupar, Cesar Department, Colombia
Local Institution - 0154
Bogota, Cundinamarca, Colombia
Local Institution - 0324
Piedecuesta, Santander Department, Colombia
Local Institution - 0155
Cali, Colombia
Local Institution - 0032
Aarhus, Central Jutland, Denmark
Local Institution - 0065
Roskilde, Region Sjælland, Denmark
Local Institution - 0129
Odense, Region Syddanmark, Denmark
Local Institution - 0125
Vejle, Denmark
Local Institution - 0124
Ulm, Baden-Wurttemberg, Germany