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Olpasiran Trials of Cardiovascular Events and Lipoprotein(a) Reduction (OCEAN(a)) - Outcomes Trial
Sponsor: Amgen
Summary
The primary objective of this trial is to compare the effect of treatment with olpasiran, to placebo, on the risk for coronary heart disease death (CHD death), myocardial infarction, or urgent coronary revascularization in participants with atherosclerotic cardiovascular disease (ASCVD) and elevated Lipoprotein(a).
Official title: A Double-blind, Randomized, Placebo-controlled, Multicenter Study Assessing the Impact of Olpasiran on Major Cardiovascular Events in Participants With Atherosclerotic Cardiovascular Disease and Elevated Lipoprotein(a)
Key Details
Gender
All
Age Range
18 Years - 85 Years
Study Type
INTERVENTIONAL
Enrollment
7297
Start Date
2022-12-14
Completion Date
2028-03-31
Last Updated
2026-10-27
Healthy Volunteers
No
Conditions
Interventions
Placebo
Placebo given by subcutaneous injection once every 12 weeks (Q12W).
Olpasiran
Olpasiran given by subcutaneous injection Q12W.
Locations (492)
University of Alabama Saint Vincent's Birmingham
Birmingham, Alabama, United States
Grandview Medical Center Affinity Cardiovascular Specialists, LLC
Birmingham, Alabama, United States
Huntsville Clinical Research, LLC
Huntsville, Alabama, United States
Mobile Heart Specialists PC
Mobile, Alabama, United States
HonorHealth Research and Innovation Institute
Phoenix, Arizona, United States
Elite Clinical Studies LLC
Phoenix, Arizona, United States
National Heart Institute
Beverly Hills, California, United States
Pacific Oaks Medical Group
Beverly Hills, California, United States
University of California San Diego
La Jolla, California, United States
VA Greater Los Angeles Healthcare System
Los Angeles, California, United States
University of California Irvine
Orange, California, United States
University of California Los Angeles
Santa Monica, California, United States
Manshadi Heart Institute
Stockton, California, United States
Med Partners, Inc dba Premiere Medical Center, Inc
Toluca Lake, California, United States
UCHealth Memorial Central
Colorado Springs, Colorado, United States
Cardiology Associates of Fairfield County PC
Stamford, Connecticut, United States
MedStar Clinical Research
Washington D.C., District of Columbia, United States
Bay Area Cardiology
Brandon, Florida, United States
Clearwater Cardiovascular Consultants
Clearwater, Florida, United States
Cardiology Associates Research LLC
Daytona Beach, Florida, United States
Jellinger and Lerman MD PA dba The Center for Diabetes and Endocrine Care
Fort Lauderdale, Florida, United States
Elite Cardiac Research Center LLC
Hialeah, Florida, United States
East Coast Institute for Research, LLC
Jacksonville, Florida, United States
Westside Center for Clinical Research
Jacksonville, Florida, United States
University of Florida
Jacksonville, Florida, United States
East Coast Institute for Research LLC
Jacksonville, Florida, United States
Jacksonville Center for Clinical Research
Jacksonville, Florida, United States
Excel Medical Clinical Trials
Miami, Florida, United States
Advanced Research for Health Improvement, LLC
Naples, Florida, United States
Ocala Cardiovascular Research
Ocala, Florida, United States
AdventHealth Medical Group Cardiology at Orlando
Orlando, Florida, United States
East Coast Institute for Research, LLC
Saint Augustine, Florida, United States
Saint Johns Center for Clinical Research
Saint Augustine, Florida, United States
Cardiovascular Center of Sarasota
Sarasota, Florida, United States
Piedmont Healthcare
Atlanta, Georgia, United States
Morehouse School of Medicine
Atlanta, Georgia, United States
Northeast Georgia Medical Center Wisteria Building
Cumming, Georgia, United States
Nsc Research
Johns Creek, Georgia, United States
St Lukes Idaho
Meridian, Idaho, United States
Endeavor Health-Northwest Community Healthcare
Arlington Heights, Illinois, United States
Endeavor Health Skokie Hospital
Evanston, Illinois, United States
Advocate Lutheran General Hospital
Park Ridge, Illinois, United States
Cardiovascular Research of Northwest Indiana LLC
Munster, Indiana, United States
Reid Physician Associates
Richmond, Indiana, United States
MercyOne Iowa Heart Center
West Des Moines, Iowa, United States
University of Kansas Medical Center
Kansas City, Kansas, United States
Midwest Heart and Vascular Specialists
Overland Park, Kansas, United States
Saint Elizabeth Covington
Covington, Kentucky, United States
The Research Group of Lexington LLC
Lexington, Kentucky, United States
Louisiana Heart Center
Covington, Louisiana, United States
Clinical Trials of America Inc
Monroe, Louisiana, United States
Monroe Research LLC
West Monroe, Louisiana, United States
Northern Light Eastern Maine Medical Center
Bangor, Maine, United States
University of Maryland Medical Center
Baltimore, Maryland, United States
Ascension Saint Agnes Heart Care
Baltimore, Maryland, United States
Johns Hopkins University
Baltimore, Maryland, United States
Metropolitan Cardiovascular Consultants LLC
Beltsville, Maryland, United States
TidalHealth Peninsula Regional, Inc
Salisbury, Maryland, United States
Brigham and Womens Hospital
Boston, Massachusetts, United States
Henry Ford Health System
Detroit, Michigan, United States
Sparrow Clinical Research Institute
Lansing, Michigan, United States
Advanced Cardiology Associates
Rochester Hills, Michigan, United States
Healthy Heart Cardiology
Rochester Hills, Michigan, United States
Arcturus Healthcare, Public Limited Company, Troy Internal Medicine Research Division
Troy, Michigan, United States
Fairview Health Services M Health Fairview St Johns Hospital
Maplewood, Minnesota, United States
Minneapolis Heart Institute Foundation
Minneapolis, Minnesota, United States
University of Minnesota
Minneapolis, Minnesota, United States
Mayo Clinic
Rochester, Minnesota, United States
Cardiology Associates Research LLC
Tupelo, Mississippi, United States
Saint Louis Heart and Vascular PC
St Louis, Missouri, United States
Bryan Heart
Lincoln, Nebraska, United States
Palm Research Center Inc
Las Vegas, Nevada, United States
Renown Institute for Heart and Vascular Health
Reno, Nevada, United States
Saint Michaels Medical Center
Newark, New Jersey, United States
Overlook Medical Center
Summit, New Jersey, United States
Northwell Health Physician Partners Cardiology at Manhasset
Manhasset, New York, United States
New York University Grossman School of Medicine and New York University Langone Hospitals
New York, New York, United States
Northwell Health Lenox Hill Heart and Vascular
New York, New York, United States
Icahn School of Medicine at Mount Sinai
New York, New York, United States
Northwell Health Physician Partners at Peconic
Riverhead, New York, United States
Stony Brook University Hospital
Stony Brook, New York, United States
WMCHealth Heart and Vascular Institute Kingston Division of Cardiology
Valhalla, New York, United States
White Plains Hospital Physician Associates - Hudson Valley Cardiovascular Group
Yorktown Heights, New York, United States
Asheville Cardiology Associates
Asheville, North Carolina, United States
Novant Health Heart and Vascular Institute
Charlotte, North Carolina, United States
Duke University
Durham, North Carolina, United States
Moses H Cone Memorial Hospital
Greensboro, North Carolina, United States
Wake Forest University Health Sciences
Winston-Salem, North Carolina, United States
Lillestol Research LLC
Fargo, North Dakota, United States
TriHealth Good Samaritan Hospital
Cincinnati, Ohio, United States
University Hospitals Cleveland Medical Center
Cleveland, Ohio, United States
The OhioHealth Research Institute
Columbus, Ohio, United States
Kettering Medical Center
Kettering, Ohio, United States
Rama Research LLC
Marion, Ohio, United States
Oregon Health and Science University
Portland, Oregon, United States
Capital Area Research LLC
Newport, Pennsylvania, United States
University of Pennsylvania
Philadelphia, Pennsylvania, United States
Montefiore Medical Center - Bronx
Philadelphia, Pennsylvania, United States
Allegheny General Hospital
Pittsburgh, Pennsylvania, United States
Medical University of South Carolina
Charleston, South Carolina, United States