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A Study of Mavacamten in Non-Obstructive Hypertrophic Cardiomyopathy
Sponsor: Bristol-Myers Squibb
Summary
The purpose of this study is to evaluate the safety, tolerability, and efficacy of mavacamten compared with placebo in participants with symptomatic non-obstructive hypertrophic cardiomyopathy (nHCM).
Official title: A Randomized, Double-blind, Placebo-controlled Clinical Study to Evaluate Mavacamten in Adults With Symptomatic Non-obstructive Hypertrophic Cardiomyopathy
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
580
Start Date
2022-12-14
Completion Date
2025-10-20
Last Updated
2026-09-18
Healthy Volunteers
No
Conditions
Interventions
Mavacamten
Specified dose on specified days
Placebo
Specified dose on specified days
Locations (224)
Local Institution - 0082
Birmingham, Alabama, United States
Local Institution - 0458
Phoenix, Arizona, United States
Local Institution - 0409
La Jolla, California, United States
Local Institution - 0010
Los Angeles, California, United States
Local Institution - 0406
San Francisco, California, United States
Local Institution - 0079
Stanford, California, United States
Local Institution - 0468
Gainesville, Florida, United States
Local Institution - 0281
Tampa, Florida, United States
Local Institution - 0092
Atlanta, Georgia, United States
Local Institution - 0424
Indianapolis, Indiana, United States
Local Institution - 0070
Iowa City, Iowa, United States
Local Institution - 0410
Kansas City, Kansas, United States
Local Institution - 0484
Louisville, Kentucky, United States
Local Institution - 0127
Baltimore, Maryland, United States
Local Institution - 0479
Boston, Massachusetts, United States
Local Institution - 0500
Boston, Massachusetts, United States
Local Institution - 0464
Ann Arbor, Michigan, United States
Local Institution - 0064
Detroit, Michigan, United States
Local Institution - 0455
Grand Rapids, Michigan, United States
Local Institution - 0431
Rochester, Minnesota, United States
Local Institution - 0461
St Louis, Missouri, United States
Local Institution - 0435
Omaha, Nebraska, United States
Local Institution - 0490
Morristown, New Jersey, United States
Local Institution - 0449
Manhasset, New York, United States
Local Institution - 0486
New York, New York, United States
Local Institution - 0007
Stony Brook, New York, United States
Local Institution - 0426
Valhalla, New York, United States
Local Institution - 0094
Charlotte, North Carolina, United States
Local Institution - 0065
Durham, North Carolina, United States
Local Institution - 0083
Cleveland, Ohio, United States
Local Institution - 0047
Hershey, Pennsylvania, United States
Local Institution - 0444
Lancaster, Pennsylvania, United States
Local Institution - 0263
Philadelphia, Pennsylvania, United States
Local Institution - 0081
Pittsburgh, Pennsylvania, United States
Local Institution - 0207
Germantown, Tennessee, United States
Local Institution - 0089
Dallas, Texas, United States
Local Institution - 0365
Dallas, Texas, United States
Local Institution - 0492
Plano, Texas, United States
Local Institution - 0402
Salt Lake City, Utah, United States
Local Institution - 0478
Charlottesville, Virginia, United States
Local Institution - 0095
Richmond, Virginia, United States
Local Institution - 0063
Concord, New South Wales, Australia
Local Institution - 0085
Darlinghurst, New South Wales, Australia
Local Institution - 0369
Sydney, New South Wales, Australia
Local Institution - 0080
Chermside, Queensland, Australia
Local Institution - 0078
Milton, Queensland, Australia
Local Institution - 0050
Bedford Park, South Australia, Australia
Local Institution - 0076
Murdoch, Western Australia, Australia
Local Institution - 0090
Innsbruck, Tyrol, Austria
Local Institution - 0075
Linz, Upper Austria, Austria
Local Institution - 0069
Braunau am Inn, Upper Austria (Oberösterreich), Austria
Local Institution - 0062
Graz, Austria
Local Institution - 0429
Vienna, Austria
Local Institution - 0462
Edegem, Antwerpen, Belgium
Local Institution - 0034
Anderlecht, Brussels Capital, Belgium
Local Institution - 0476
Genk, Limburg, Belgium
Local Institution - 0319
Leuven, Vlaams Brabant, Belgium
Local Institution - 0413
Salvador, Estado de Bahia, Brazil
Local Institution - 0438
Brasília, Federal District, Brazil
Local Institution - 0488
Belo Horizonte, Minas Gerais, Brazil
Local Institution - 0447
Porto Alegre, Rio Grande do Sul, Brazil
Local Institution - 0450
Porto Alegre, Rio Grande do Sul, Brazil
Local Institution - 0430
Bragança Paulista, São Paulo, Brazil
Local Institution - 0422
Ribeirão Preto, São Paulo, Brazil
Local Institution - 0412
São Paulo, São Paulo, Brazil
Local Institution - 0446
Rio de Janeiro, Brazil
Local Institution - 0451
Rio de Janeiro, Brazil
Local Institution - 0418
São Paulo, Brazil
Local Institution - 0381
Calgary, Alberta, Canada
Local Institution - 0467
Vancouver, British Columbia, Canada
Local Institution - 0414
Hamilton, Ontario, Canada
Local Institution - 0411
London, Ontario, Canada
Local Institution - 0093
Québec, Quebec, Canada
Local Institution - 0535
Beijing, Beijing Municipality, China
Local Institution - 0534
Beijing, Beijing Municipality, China
Local Institution - 0503
Chongqing, Chongqing Municipality, China
Local Institution - 0541
Chongqing, Chongqing Municipality, China
Local Institution - 0539
Guangzhou, Guangdong, China
Local Institution - 0543
Guangzhou, Guangdong, China
Local Institution - 0549
Zhengzhou, Henan, China
Local Institution - 0542
Wuhan, Hubei, China
Local Institution - 0548
Changsha, Hunan, China
Local Institution - 0545
Suzhou, Jiangsu, China
Local Institution - 0550
Nanchang, Jiangxi, China
Local Institution - 0544
Changchun, Jilin, China
Local Institution - 0540
Dalian, Liaoning, China
Local Institution - 0501
Shenyang, Liaoning, China
Local Institution - 0538
Shenyang, Liaoning, China
Local Institution - 0547
Xi'an, Shan1xi, China
Local Institution - 0546
Jinan, Shandong, China
Local Institution - 0537
Shanghai, Shanghai Municipality, China
Local Institution - 0533
Chengdu, Sichuan, China
Local Institution - 0552
Chengdu, Sichuan, China
Local Institution - 0536
Wenzhou, Zhejiang, China
Local Institution - 0502
Beijing, China
Local Institution - 0553
Beijing, China
Local Institution - 0086
Broumov, Hradec Králové Region, Czechia
Local Institution - 0052
Prague, Praha, Hlavní Mesto, Czechia
Local Institution - 0033
Prague, Praha, Hlavní Mesto, Czechia
Local Institution - 0188
Brno, Czechia