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Phase 2b Study of GSK4532990 in Adults With NASH
Sponsor: GlaxoSmithKline
Summary
The purpose of this study is to measure improvements in liver fibrosis and inflammation with GSK4532990 compared with placebo in participants with NASH and advanced fibrosis on biopsy (F3 or F4). The study duration will be up to 76 weeks including the screening period. The treatment duration will be up to 52 weeks.
Official title: 17 β-Hydroxysteroid Dehydrogenase Type 13 Minimization for the Treatment of NASH (HORIZON): A Double-Blind, Placebo-Controlled Phase 2b Study to Evaluate the Efficacy and Safety of GSK4532990 in Adults With Nonalcoholic Steatohepatitis
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
284
Start Date
2023-01-02
Completion Date
2026-09-18
Last Updated
2026-09-18
Healthy Volunteers
No
Interventions
GSK4532990
GSK4532990 will be administered.
Placebo
Placebo will be administered.
Locations (170)
GSK Investigational Site
Homewood, Alabama, United States
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Chandler, Arizona, United States
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Chandler, Arizona, United States
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Mesa, Arizona, United States
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Jonesboro, Arkansas, United States
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North Little Rock, Arkansas, United States
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Huntington Park, California, United States
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La Jolla, California, United States
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Orange, California, United States
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Poway, California, United States
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Rialto, California, United States
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Sacramento, California, United States
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San Francisco, California, United States
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Santa Ana, California, United States
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Van Nuys, California, United States
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Colorado Springs, Colorado, United States
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Bradenton, Florida, United States
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Coral Gables, Florida, United States
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Fort Myers, Florida, United States
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Hallandale, Florida, United States
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Hialeah, Florida, United States
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Homestead, Florida, United States
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Jupiter, Florida, United States
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Lakewood Rch, Florida, United States
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Miami, Florida, United States
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Miami, Florida, United States
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Miami, Florida, United States
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Miami Lakes, Florida, United States
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West Palm Beach, Florida, United States
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Athens, Georgia, United States
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Atlanta, Georgia, United States
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Marietta, Georgia, United States
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Snellville, Georgia, United States
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Indianapolis, Indiana, United States
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South Bend, Indiana, United States
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Iowa City, Iowa, United States
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Topeka, Kansas, United States
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Bastrop, Louisiana, United States
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Marrero, Louisiana, United States
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Metairie, Louisiana, United States
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Monroe, Louisiana, United States
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Shreveport, Louisiana, United States
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Columbia, Maryland, United States
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Greenbelt, Maryland, United States
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Ann Arbor, Michigan, United States
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Southfield, Michigan, United States
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Ypsilanti, Michigan, United States
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Chesterfield, Missouri, United States
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Las Vegas, Nevada, United States
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Princeton, New Jersey, United States
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Sparta, New Jersey, United States
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New York, New York, United States
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New York, New York, United States
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New York, New York, United States
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Chapel Hill, North Carolina, United States
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Durham, North Carolina, United States
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Morehead City, North Carolina, United States
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Akron, Ohio, United States
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Springboro, Ohio, United States
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Westlake, Ohio, United States
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Lancaster, Pennsylvania, United States
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Pittsburgh, Pennsylvania, United States
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Wyomissing, Pennsylvania, United States
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Chattanooga, Tennessee, United States
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Clarksville, Tennessee, United States
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Austin, Texas, United States
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Brownsville, Texas, United States
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Dallas, Texas, United States
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Edinburg, Texas, United States
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Georgetown, Texas, United States
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Houston, Texas, United States
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Houston, Texas, United States
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Houston, Texas, United States
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San Antonio, Texas, United States
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San Antonio, Texas, United States
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Waco, Texas, United States
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West Jordan, Utah, United States
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Richmond, Virginia, United States
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Richmond, Virginia, United States
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Seattle, Washington, United States
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Buenos Aires, Argentina
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Capital Federal, Argentina
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Ciudad AutOnoma de Buenos Aire, Argentina
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Ciudad Autonoma de Bueno, Argentina
GSK Investigational Site
Derqui Pilar, Argentina
GSK Investigational Site
Rosario, Argentina
GSK Investigational Site
San Miguel de Tucumán, Argentina
GSK Investigational Site
Nedlands, Western Australia, Australia
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Perth, Western Australia, Australia
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Brussels, Belgium
GSK Investigational Site
Brussels, Belgium
GSK Investigational Site
Edegem, Belgium
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Calgary, Alberta, Canada
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Toronto, Ontario, Canada
GSK Investigational Site
Angers, France
GSK Investigational Site
Limoges, France
GSK Investigational Site
Paris, France
GSK Investigational Site
Pierre-Bénite, France
GSK Investigational Site
Strasbourg, France
GSK Investigational Site
Athens, Greece