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A 52-Week Study of the Efficacy and Safety of BLU-5937 in Adults With Refractory Chronic Cough
Sponsor: Bellus Health Inc. - a GSK company
Summary
This is a randomized, double-blind, placebo-controlled, parallel-arm, Phase 3 study of BLU-5937 in participants with Refractory Chronic Cough (RCC).
Official title: A Phase 3, 52-Week, Randomized, Double-Blind, Placebo-Controlled, Parallel-Arm Efficacy and Safety Study With Open-Label Extension of BLU-5937 in Adult Participants With Refractory Chronic Cough, Including Unexplained Chronic Cough (CALM-1)
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
957
Start Date
2022-10-25
Completion Date
2026-06-18
Last Updated
2026-07-14
Healthy Volunteers
No
Conditions
Interventions
BLU-5937
Oral administration of BLU-5937 Tablets
Placebo
Oral administration of matching placebo for BLU-5937 Tablets
Locations (200)
GSK Investigational Site
Jasper, Alabama, United States
GSK Investigational Site
Litchfield Park, Arizona, United States
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Scottsdale, Arizona, United States
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Little Rock, Arkansas, United States
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Encinitas, California, United States
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Mission Viejo, California, United States
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Paramount, California, United States
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Roseville, California, United States
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Aurora, Colorado, United States
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Colorado Springs, Colorado, United States
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Clearwater, Florida, United States
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Gainesville, Florida, United States
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Miami, Florida, United States
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Miami, Florida, United States
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Miami, Florida, United States
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Miami, Florida, United States
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Orlando, Florida, United States
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Lawrenceville, Georgia, United States
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Normal, Illinois, United States
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Oak Lawn, Illinois, United States
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Ames, Iowa, United States
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Iowa City, Iowa, United States
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Kansas City, Kansas, United States
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Topeka, Kansas, United States
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Wichita, Kansas, United States
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Crowley, Louisiana, United States
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Shreveport, Louisiana, United States
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Annapolis, Maryland, United States
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North Dartmouth, Massachusetts, United States
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Ann Arbor, Michigan, United States
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Ypsilanti, Michigan, United States
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Columbia, Missouri, United States
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St Louis, Missouri, United States
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St Louis, Missouri, United States
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Missoula, Montana, United States
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Jersey City, New Jersey, United States
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The Bronx, New York, United States
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Charlotte, North Carolina, United States
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Raleigh, North Carolina, United States
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Rocky Mount, North Carolina, United States
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Salisbury, North Carolina, United States
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Winston-Salem, North Carolina, United States
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Columbus, Ohio, United States
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Dayton, Ohio, United States
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Oklahoma City, Oklahoma, United States
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Tulsa, Oklahoma, United States
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Medford, Oregon, United States
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Portland, Oregon, United States
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Philadelphia, Pennsylvania, United States
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Warwick, Rhode Island, United States
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Charleston, South Carolina, United States
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Little River, South Carolina, United States
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Mt. Pleasant, South Carolina, United States
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Rock Hill, South Carolina, United States
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Bristol, Tennessee, United States
GSK Investigational Site
Knoxville, Tennessee, United States
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Dallas, Texas, United States
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Houston, Texas, United States
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Houston, Texas, United States
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McKinney, Texas, United States
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San Antonio, Texas, United States
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Waco, Texas, United States
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Salt Lake City, Utah, United States
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Norfolk, Virginia, United States
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Williamsburg, Virginia, United States
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Bellevue, Washington, United States
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Bellingham, Washington, United States
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Buenos Aires, Argentina
GSK Investigational Site
Buenos Aires, Argentina
GSK Investigational Site
Ciudad Autonoma Buenos Aires, Argentina
GSK Investigational Site
Ciudad Autonoma de Bueno, Argentina
GSK Investigational Site
Córdoba, Argentina
GSK Investigational Site
Mar del Plata, Argentina
GSK Investigational Site
Mendoza, Argentina
GSK Investigational Site
Rosario, Argentina
GSK Investigational Site
Rosario, Argentina
GSK Investigational Site
Rosario, Argentina
GSK Investigational Site
San Miguel de Tucumán, Argentina
GSK Investigational Site
Santa Fe, Argentina
GSK Investigational Site
Vicente López, Argentina
GSK Investigational Site
Brussels, Belgium
GSK Investigational Site
Ghent, Belgium
GSK Investigational Site
Kortrijk, Belgium
GSK Investigational Site
Leuven, Belgium
GSK Investigational Site
Liège, Belgium
GSK Investigational Site
Mechelen, Belgium
GSK Investigational Site
Roeselare, Belgium
GSK Investigational Site
Calgary, Alberta, Canada
GSK Investigational Site
Calgary, Alberta, Canada
GSK Investigational Site
Kelowna, British Columbia, Canada
GSK Investigational Site
Ajax, Ontario, Canada
GSK Investigational Site
Hamilton, Ontario, Canada
GSK Investigational Site
Hamilton, Ontario, Canada
GSK Investigational Site
Toronto, Ontario, Canada
GSK Investigational Site
Windsor, Ontario, Canada
GSK Investigational Site
Greenfield Park, Quebec, Canada
GSK Investigational Site
Montreal, Quebec, Canada
GSK Investigational Site
Montreal, Quebec, Canada
GSK Investigational Site
Québec, Quebec, Canada
GSK Investigational Site
Québec, Quebec, Canada