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A 24-Week Study of the Efficacy and Safety of BLU-5937 in Adults With Refractory Chronic Cough
Sponsor: Bellus Health Inc. - a GSK company
Summary
This is a randomized, double-blind, placebo-controlled, parallel-arm, Phase 3 study of BLU-5937 in participants with Refractory Chronic Cough (RCC).
Official title: A Phase 3, 24-Week, Randomized, Double-Blind, Placebo-Controlled, Parallel-Arm Efficacy and Safety Study With Open-label Extension of BLU-5937 in Adult Participants With Refractory Chronic Cough Including Unexplained Chronic Cough (CALM-2)
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
997
Start Date
2022-12-05
Completion Date
2027-03-17
Last Updated
2026-07-14
Healthy Volunteers
No
Conditions
Interventions
BLU-5937
Oral administration of BLU-5937 Tablets
Placebo
Oral administration of matching placebo for BLU-5937 Tablets
Locations (242)
GSK Investigational Site
Foley, Alabama, United States
GSK Investigational Site
Litchfield Park, Arizona, United States
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Phoenix, Arizona, United States
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Los Angeles, California, United States
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Los Angeles, California, United States
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Paramount, California, United States
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Sacramento, California, United States
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San Diego, California, United States
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San Diego, California, United States
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San Jose, California, United States
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Aurora, Colorado, United States
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Colorado Springs, Colorado, United States
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Denver, Colorado, United States
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Wheat Ridge, Colorado, United States
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Washington D.C., District of Columbia, United States
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Daytona Beach, Florida, United States
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Fort Lauderdale, Florida, United States
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Jacksonville, Florida, United States
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Leesburg, Florida, United States
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Orlando, Florida, United States
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Santa Rosa Beach, Florida, United States
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Sarasota, Florida, United States
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Sweetwater, Florida, United States
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Cumming, Georgia, United States
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Chicago, Illinois, United States
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River Forest, Illinois, United States
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West Des Moines, Iowa, United States
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Lexington, Kentucky, United States
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Chevy Chase, Maryland, United States
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Methuen, Massachusetts, United States
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North Dartmouth, Massachusetts, United States
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Ypsilanti, Michigan, United States
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Edina, Minnesota, United States
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Woodbury, Minnesota, United States
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St Louis, Missouri, United States
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St Louis, Missouri, United States
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Missoula, Montana, United States
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Omaha, Nebraska, United States
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Charlotte, North Carolina, United States
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Gastonia, North Carolina, United States
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Winston-Salem, North Carolina, United States
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Columbus, Ohio, United States
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Tulsa, Oklahoma, United States
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Portland, Oregon, United States
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Danville, Pennsylvania, United States
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Philadelphia, Pennsylvania, United States
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Warwick, Rhode Island, United States
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Anderson, South Carolina, United States
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Charleston, South Carolina, United States
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Charleston, South Carolina, United States
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Franklin, Tennessee, United States
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Dallas, Texas, United States
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Round Rock, Texas, United States
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San Antonio, Texas, United States
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San Antonio, Texas, United States
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Norfolk, Virginia, United States
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Bellingham, Washington, United States
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Coffs Harbour, New South Wales, Australia
GSK Investigational Site
Macquarie University, New South Wales, Australia
GSK Investigational Site
New Lambton Heights, New South Wales, Australia
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St Leonards, New South Wales, Australia
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Chermside, Queensland, Australia
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Adelaide, South Australia, Australia
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St Albans, Victoria, Australia
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Nedlands, Western Australia, Australia
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Spearwood, Western Australia, Australia
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Calgary, Alberta, Canada
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Ajax, Ontario, Canada
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Hamilton, Ontario, Canada
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Hamilton, Ontario, Canada
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Toronto, Ontario, Canada
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Windsor, Ontario, Canada
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Montreal, Quebec, Canada
GSK Investigational Site
Québec, Quebec, Canada
GSK Investigational Site
Québec, Quebec, Canada
GSK Investigational Site
Saint-Charles-Borromée, Quebec, Canada
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Trois-Rivières, Quebec, Canada
GSK Investigational Site
Victoriaville, Quebec, Canada
GSK Investigational Site
Burlington, Canada
GSK Investigational Site
Kunshan, Jiangsu, China
GSK Investigational Site
Leshan, Sichuan, China
GSK Investigational Site
Ürümqi, Xinjiang, China
GSK Investigational Site
Beijing, China
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Changsha, China
GSK Investigational Site
Chengdu, China
GSK Investigational Site
Chengdu, China
GSK Investigational Site
Chongqing, China
GSK Investigational Site
Dongguan, China
GSK Investigational Site
Ganzhou, China
GSK Investigational Site
Guangzhou, China
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Guangzhou, China
GSK Investigational Site
Guilin, China
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Hangzhou, China
GSK Investigational Site
Hefei, China
GSK Investigational Site
Hefei, China
GSK Investigational Site
Hohhot, China
GSK Investigational Site
Huizhou, China
GSK Investigational Site
Huizhou, China
GSK Investigational Site
Jiangsu, China
GSK Investigational Site
Jinan, China