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Study to Compare Furmonertinib to Platinum-Based Chemotherapy for Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) With Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Mutations (FURVENT)
Sponsor: ArriVent BioPharma, Inc.
Summary
Global, Phase 3, randomized, multicenter, open-label study evaluating the efficacy and safety of furmonertinib (firmonertinib) at 2 dose levels (160 mg once daily \[QD\] and 240 mg QD) compared to platinum-based chemotherapy in previously untreated patients with locally advanced or metastatic non-squamous Non-Small Cell Lung Cancer (NSCLC) with Epidermal Growth Factor Receptor (EGFR) exon 20 insertion mutations. A target of approximately 375 patients will be randomized in a 1:1:1 ratio to treatment with furmonertinib 240 mg QD, furmonertinib 160 mg QD, or platinum-based chemotherapy.
Official title: A Global, Phase 3, Randomized, Multicenter, Open-Label Study to Investigate the Efficacy and Safety of Furmonertinib Compared to Platinum-Based Chemotherapy as First-Line Treatment for Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) With Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Mutations (FURVENT)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
398
Start Date
2023-06-01
Completion Date
2028-02-15
Last Updated
2026-11-02
Healthy Volunteers
No
Conditions
Interventions
furmonertinib 240 mg oral, daily
furmonertinib tablet
furmonertinib 160 mg oral, daily
furmonertinib tablet
platinum-based chemotherapy
(carboplatin or cisplatin based on investigator's choice) + pemetrexed intravenously (IV)
Locations (208)
Arrivent Investigative Site
Daphne, Alabama, United States
Arrivent Investigative Site
Yuma, Arizona, United States
Arrivent Investigative Site
Fayetteville, Arkansas, United States
Arrivent Investigative Site
Beverly Hills, California, United States
Arrivent Investigative Site
Fullerton, California, United States
Arrivent Investigative Site
Long Beach, California, United States
Arrivent Investigative Site
Los Alamitos, California, United States
Arrivent Investigative Site
Napa, California, United States
Arrivent Investigative Site
Orange, California, United States
Arrivent Investigative Site
Orange, California, United States
Arrivent Investigative site
Sacramento, California, United States
Arrivent Investigative Site
San Diego, California, United States
Arrivent Investigative Site
Santa Barbara, California, United States
Arrivent Investigative Site
Santa Monica, California, United States
Arrivent Investigative Site
Santa Rosa, California, United States
Arrivent Investigative Site
Whittier, California, United States
Arrivent Investigative Site
Hartford, Connecticut, United States
Arrivent Investigative Site
Norwich, Connecticut, United States
Arrivent Investigative Site
Fort Myers, Florida, United States
Arrivent Investigative Site
St. Petersburg, Florida, United States
Arrivent Investigative Site
The Villages, Florida, United States
Arrivent Investigative Site
Peoria, Illinois, United States
Arrivent Investigative Site
Rolling Meadows, Illinois, United States
Arrivent Investigative Site
Fort Wayne, Indiana, United States
Arrivent Investigative Site
Indianapolis, Indiana, United States
Arrivent Investigative Site
South Bend, Indiana, United States
Arrivent Investigative Site
Bethesda, Maryland, United States
Arrivent Investigative Site
Frederick, Maryland, United States
Arrivent Investigative Site
Rockville, Maryland, United States
Arrivent Investigative Site
Fairhaven, Massachusetts, United States
Arrivent Investigative Site
Lansing, Michigan, United States
Arrivent Investigative Site
Bolivar, Missouri, United States
Arrivent Investigative Site
Kansas City, Missouri, United States
Arrivent Investigative Site
Saint Joseph, Missouri, United States
Arrivent Investigative Site
St Louis, Missouri, United States
Arrivent Investigative Site
Omaha, Nebraska, United States
Arrivent Investigative Site
Belleville, New Jersey, United States
Arrivent Investigative Site
Englewood, New Jersey, United States
Arrivent Investigative Site
Florham Park, New Jersey, United States
Arrivent Investigative Site
The Bronx, New York, United States
Arrivent Investigative Site
Goldsboro, North Carolina, United States
ArriVent Investigative Site
Pinehurst, North Carolina, United States
Arrivent Investigative Site
Canton, Ohio, United States
Arrivent Investigative Site
Cincinnati, Ohio, United States
ArriVent Investigative Site
Cincinnati, Ohio, United States
Arrivent Investigative Site
Cleveland, Ohio, United States
Arrivent Investigative Site
Columbus, Ohio, United States
Arrivent Investigative Site
Oklahoma City, Oklahoma, United States
Arrivent Investigative Site
Tulsa, Oklahoma, United States
Arrivent Investigative Site
Salem, Oregon, United States
Arrivent Investigative Site
Gettysburg, Pennsylvania, United States
ArriVent Investigative Site
Langhorne, Pennsylvania, United States
Arrivent Investigative Site
York, Pennsylvania, United States
Arrivent Investigative Site
Greenville, South Carolina, United States
Arrivent Investigative Site
Sioux Falls, South Dakota, United States
Arrivent Investigative Site
Memphis, Tennessee, United States
ArriVent Investigative Site
Nashville, Tennessee, United States
Arrivent Investigative Site
Abilene, Texas, United States
ArriVent Investigative Site
Austin, Texas, United States
Arrivent Investigative Site
Houston, Texas, United States
Arrivent Investigative Site
Plano, Texas, United States
Arrivent Investigative Site
Ogden, Utah, United States
Arrivent Investigative Site
Salt Lake City, Utah, United States
ArriVent Investigative Site
Fairfax, Virginia, United States
Arrivent Investigative Site
Fredericksburg, Virginia, United States
Arrivent Investigative Site
Bellingham, Washington, United States
Arrivent Investigative Site
Spokane Valley, Washington, United States
Arrivent Investigative Site
Tacoma, Washington, United States
Arrivent Investigative Site
Appleton, Wisconsin, United States
ArriVent Investigative Site
Heidelberg, Victoria, Australia
Arrivent Investigative Site
Blacktown, Australia
Arrivent Investigative Site
St Leonards, Australia
Arrivent Investigative Site
Woolloongabba, Australia
ArriVent Investigative Site
Salvador, Estado de Bahia, Brazil
ArriVent Investigative Site
Belo Horizonte, Minas Gerais, Brazil
ArriVent Investigative Site
Porto Alegre, Porto Alegre, Brazil
ArriVent Investigative Site
Rio de Janeiro, Rio de Janeiro, Brazil
ArriVent Investigative Site
Rio de Janeiro, Rio de Janeiro, Brazil
ArriVent Investigative Site
Pelotas, Rio Grande do Sul, Brazil
ArriVent Investigative Site
Porto Alegre, Rio Grande, Brazil
ArriVent Investigative Site
Blumenau, SC Cep, Brazil
ArriVent Investigative Site
São José do Rio Preto, São Paulo, Brazil
ArriVent Investigative Site
São Paulo, São Paulo, Brazil
ArriVent Investigative Site
Liberdade, São Paulo/SP, Brazil
ArriVent Investigative Site
Taubaté, Taubate SP, Brazil
ArriVent Investigative Site
Edmonton, Alberta, Canada
ArriVent Investigative Site
Toronto, Ontario, Canada
Allist Investigative Site
Beijing, Beijing Municipality, China
Allist Investigative Site
Meizhou, Guangdong, China
Allist Investigative Site
Xuhui, Hai City, China
Allist Investigative Site
Hangzhou, Hangzhou, China
Allist Investigative Site
Cangzhou, Hebei, China
Allist Investigative Site
Shushan, Hefei, China
Allist Investigative Site
Zhengzhou, Henan, China
Allist Investigative Site
Changchun, Jilin, China
Allist Investigative Site
Weihai, Lingang Economic and Technological Development Zo, China
Allist Investigative Site
Nanning, Nanning, China
Allist Investigative Site
Yangpu, Shanghai Municipality, China
Allist Investigative Site
Xi’an, Shanxi, China
Allist Investigative Site
Taiyuan, Taiyuan, China