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CORE-OLE: A Study of Olezarsen (ISIS 678354) Administered Subcutaneously to Participants With Severe Hypertriglyceridemia (SHTG)
Sponsor: Ionis Pharmaceuticals, Inc.
Summary
The purpose of this study is to evaluate the safety and tolerability of olezarsen in participants with SHTG.
Official title: An Open-Label Extension Study of Olezarsen (ISIS 678354) Administered Subcutaneously to Patients With Severe Hypertriglyceridemia (SHTG)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
885
Start Date
2022-12-13
Completion Date
2027-03
Last Updated
2025-12-01
Healthy Volunteers
No
Conditions
Interventions
Olezarsen
Administered as SC injection.
Locations (262)
LA Universal Research Center, Inc.
Los Angeles, California, United States
University of California, San Diego (UCSD)
San Diego, California, United States
Metabolic Institute of America
Tarzana, California, United States
Excel Medical Clinical Trials
Boca Raton, Florida, United States
Finlay Medical Research
Greenacres City, Florida, United States
Columbus Clinical Services, LLC
Miami, Florida, United States
Finlay Medical Research
Miami, Florida, United States
Innovia Research Center, Inc.
Miramar, Florida, United States
Harmony Clinical Research, Inc.
North Miami Beach, Florida, United States
R & B Medical Center LLC
Tampa, Florida, United States
VICIS Clinical Research
Tampa, Florida, United States
JSV Clinical Research Study, Inc.
Tampa, Florida, United States
Bayside Clinical Research
Trinity, Florida, United States
Centricity Research
Columbus, Georgia, United States
IACT Health
Columbus, Georgia, United States
Affinity Health
Oak Brook, Illinois, United States
St. Vincent Medical Group, Inc.
Carmel, Indiana, United States
University of Kansas Medical Center (KUMC)
Kansas City, Kansas, United States
The Research Group of Lexington, LLC
Lexington, Kentucky, United States
Louisville Metabolic and Atherosclerosis Research Center (L-MARC)
Louisville, Kentucky, United States
Grace Research, LLC
Bossier City, Louisiana, United States
University of Maryland School of Medicine
Baltimore, Maryland, United States
IRC Clinics
Towson, Maryland, United States
Massachusetts General Hospital Heart Center
Boston, Massachusetts, United States
University of Michigan- Endocrinology & Metabolism
Ann Arbor, Michigan, United States
Aa Mrc, Llc
Flint, Michigan, United States
Washington School of Medicine
St Louis, Missouri, United States
Bryan Medical Center
Lincoln, Nebraska, United States
Palm Research Center, Inc.
Las Vegas, Nevada, United States
Hudson County Clinical Trials Research Center
Union City, New Jersey, United States
Modern Medical
Brooklyn, New York, United States
NYU Langone Health
Mineola, New York, United States
Langone Medical Center
New York, New York, United States
Vagelos College of Physicians and Surgeons of Columbia University
New York, New York, United States
Orchard Park Family Practice
Orchard Park, New York, United States
The Presbyterian Hospital DBA Novant Health Heart and Vascular Institute
Charlotte, North Carolina, United States
Kenneth Hilty
Greensboro, North Carolina, United States
Clinical Trials of America, LLC
Lenoir, North Carolina, United States
Lexington
Winston-Salem, North Carolina, United States
The Ohio State University
Columbus, Ohio, United States
Central Oklahoma Early Detection Center
Edmond, Oklahoma, United States
Oklahoma Heart Institute
Tulsa, Oklahoma, United States
University of Pennsylvania
Philadelphia, Pennsylvania, United States
Medical University of South Carolina
Charleston, South Carolina, United States
Walker Family Care
Little River, South Carolina, United States
Monument Health Clinical Research
Rapid City, South Dakota, United States
Health Concepts
Rapid City, South Dakota, United States
Chattanooga Research & Medicine, PLLC
Chattanooga, Tennessee, United States
The Jackson Clinic
Jackson, Tennessee, United States
University of Texas Southwestern
Dallas, Texas, United States
Baylor College of Medicine
Houston, Texas, United States
Juno Research
Houston, Texas, United States
Pioneer Research Solutions
Houston, Texas, United States
Sante Clinical Research LLC
Kerrville, Texas, United States
FMC Science
Lampasas, Texas, United States
DCT- McAllen Primary Care, LLC
McAllen, Texas, United States
Texas Institute of Cardiology
McKinney, Texas, United States
SMS Clinical Research, LLC
Mesquite, Texas, United States
Southern Endocrinology Associates
Mesquite, Texas, United States
Permian Research Foundation
Odessa, Texas, United States
Diabetes & Glandular Disease Clinic, P.A.
San Antonio, Texas, United States
Tranquil Clinical and Research Consulting Services
Webster, Texas, United States
Manassas Clinical Research
Manassas, Virginia, United States
York Clinical Research
Norfolk, Virginia, United States
WVU Heart and Vascular Institute
Morgantown, West Virginia, United States
CIPREC
Buenos Aires, Argentina
Fundacion Favaloro
Buenos Aires, Argentina
Centro Medico Dra. Laura Maffei-Investigacion Clinica Aplicad
Buenos Aires, Argentina
Glenny Corp SA
Buenos Aires, Argentina
Instituto Medico DAMIC
Córdoba, Argentina
Clinica FUSAVIM Privada
Villa María, Argentina
Royal North Shore Hospital
Saint Leonards, New South Wales, Australia
Royal Adelaide Hospital
Adelaide, Australia
Royal Prince Alfred Hospital
Camperdown, Australia
Monash Medical Centre
Clayton, Australia
Dr Heart Pty Ltd
Woolloongabba, Australia
Universite Libre de Brussels (ULB)- Hopital Erasme
Brussels, Belgium
Jessa Ziekenhuis
Hasselt, Belgium
Universitaire Ziekenhuizen Leuven
Leuven, Belgium
Centro Especializado em Cardiologia
Campinas, Brazil
Nucleo de Pesquisa Clinica S/S
Curitiba, Brazil
Hospital Universitario Walter Cantidio- UFC
Fortaleza, Brazil
Nucleo de Pasquisa em Cirurgia Vascular
Porto Alegre, Brazil
Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo- FMUSP
São Paulo, Brazil
Instituto do Coracao (InCor) do Hospital das Clinicas da FMUSP
São Paulo, Brazil
CPQuali Pesquisa Clinica Ltda.
São Paulo, Brazil
MHAT- Blagoevgrad AD
Blagoevgrad, Bulgaria
Medical Center Doctor Staykov EOOD
Burgas, Bulgaria
Medical Center Diamedical 2013 OOD
Dimitrovgrad, Bulgaria
MHAT
Gabrovo, Bulgaria
MHAT Haskovo AD
Haskovo, Bulgaria
Multiprofile Hospital for Active Treament Pazardzhik, Cardiology Department
Pazardzhik, Bulgaria
SBAL "Special Medic" Ltd.
Plovdiv, Bulgaria
UHMAT Kaspela Ltd
Plovdiv, Bulgaria
University Multiprofile Hospital for Active Treatment Pulmed, Clinic of Endocrinology
Plovdiv, Bulgaria
Medical Center Rusemed EOOD
Rousse, Bulgaria
UMHAT Kanev AD
Rousse, Bulgaria
DCC-1 Sliven Ltd.
Sliven, Bulgaria
Medical Center Smolyan Clinical Research OOD
Smolyan, Bulgaria
Medical Center for Specialized Medical Help in Cardiovascular Diseases OOD
Sofia, Bulgaria