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Physiology-guided vs Angiography-guided Non-culprit Lesion Complete Revascularization for Acute MI & Multivessel Disease
Sponsor: Population Health Research Institute
Summary
COMPLETE-2 is a prospective, multi-centre, randomized controlled trial comparing a strategy of physiology-guided complete revascularization to angiography-guided complete revascularization in patients with acute ST-segment elevation myocardial infarction (STEMI) or non-ST-segment elevation myocardial infarction (NSTEMI) and multivessel coronary artery disease (CAD) who have undergone successful culprit lesion Percutaneous Coronary Intervention (PCI). COMPLETE-2 OCT is a large scale, prospective, multi-centre, observational, imaging study of patients with STEMI or NSTEMI and multivessel CAD in a subset of eligible COMPLETE-2 patients.
Official title: A Randomized Trial of Physiology-guided vs Angiography-guided Non-culprit Lesion Complete Revascularization Strategies & an Observational Study of Optical Coherence Tomography in Patients With Acute MI & Multivessel Coronary Artery Disease
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
5100
Start Date
2023-06-22
Completion Date
2028-06
Last Updated
2026-10-20
Healthy Volunteers
No
Interventions
Physiology-guided NCL PCI
For RFR, PCI will be performed as per local practice for all lesions with RFR ≤0.89. For FFR, PCI will be performed as per local practice for all NCLs with FFR ≤0.80.
Angiography-guided NCL PCI
PCI will be performed as per local practice
Locations (138)
UCLA
Los Angeles, California, United States
University of California, San Francisco
San Francisco, California, United States
Cardiovascular Research Institute of Kansas
Wichita, Kansas, United States
The Johns Hopkins University School of Medicine
Baltimore, Maryland, United States
University of Michigan
Ann Arbor, Michigan, United States
Metropolitan Cardiology Consultants / Metropolitan Heart and Vascular Institute (MCC/MHVI)
Coon Rapids, Minnesota, United States
RWJ Barnabas Health
Jersey City, New Jersey, United States
Bassett Medical Center
Cooperstown, New York, United States
VA New York Harbor HealthCare System
New York, New York, United States
NYU Grossman School of Medicine
New York, New York, United States
Montefiore Medical Center
The Bronx, New York, United States
Cleveland Clinic
Cleveland, Ohio, United States
The Heart Hospital Baylor Plano
Plano, Texas, United States
University of Virginia Medical Center
Charlottesville, Virginia, United States
Westmead Hospital
Westmead, New South Wales, Australia
Flinders Medical Centre
Bedford Park, Australia
Eastern Health
Box Hill, Australia
Campbelltown Hospital
Campbelltown, Australia
The Prince Charles Hospital
Chermside, Australia
Gosford Hospital
Gosford, Australia
Northern Health
Melbourne, Australia
Royal Melbourne Hospital
Parkville, Australia
Royal Perth Hospital
Perth, Australia
Klinik Floridsdorf
Vienna, Austria
McGill University Health Centre (MUHC)
Montreal, Quebec, Canada
William Osler Health System
Brampton, Canada
University of Alberta Hospital, Mazankowski Heart
Edmonton, Canada
Hamilton Health Sciences
Hamilton, Canada
Kingston Health Sciences Centre
Kingston, Canada
St. Mary's General Hospital
Kitchener, Canada
London Health Sciences Centre
London, Canada
Centre Hospitalier de l'Universite de Montreal
Montreal, Canada
Hopital du Sacre-Coeur de Montreal
Montreal, Canada
Southlake Regional Health Centre
Newmarket, Canada
Nova Scotia Health
Nova Scotia, Canada
University of Ottawa Heart Institute
Ottawa, Canada
Institut Universitaire de Cardiologie et de Pneumologie de Québec
Québec, Canada
Regina General Hospital
Regina, Canada
Royal University Hospital
Saskatoon, Canada
Niagara Health
St. Catharines, Canada
Newfoundland and Labrador Health Services
St. John's, Canada
Thunder Bay Regional Health Sciences Centre
Thunder Bay, Canada
St. Michael's Hospital (Unity Health Toronto)
Toronto, Canada
Sunnybrook Health Sciences Centre
Toronto, Canada
Ciusss McQ - Chaur
Trois-Rivières, Canada
St Paul's Hospital
Vancouver, Canada
Vancouver General Hospital
Vancouver, Canada
St. Boniface Hospital
Winnipeg, Canada
Aalborg University Hospital
Aalborg, Denmark
Aarhus University Hospital
Aarhus, Denmark
Rigshospitalet - Copenhagen University Hospital
Copenhagen, Denmark
Helsinki University Hospital
Helsinki, Finland
TAYS Sydankeskus Oy
Tampere, Finland
Turku University Hospital
Turku, Finland
Kerckhoff-Klinik Bad Nauheim
Bad Nauheim, Germany
Berufsgenossenschaftliches Universitatsklinikum
Bochum, Germany
St. Vinzenz-Hospital
Cologne, Germany
Helios Amper-Klinikum
Dachau, Germany
Universitatsklinikum Frankfurt
Frankfurt, Germany
Schoen Klink Hamburg
Hamburg, Germany
University Heart & Vascular Center Hamburg
Hamburg, Germany
WKK Heide
Heide, Germany
Heart Center Leipzig
Leipzig, Germany
General University Hospital of Patras
Rio, Greece
Gottsegen National Cardiovascular Center
Budapest, Hungary
Semmelweis University Heart and Vascular Center
Budapest, Hungary
Szabolcs-Szatmar-Bereg County Hospitals and University
Nyíregyháza, Hungary
University of Szeged
Szeged, Hungary
Lisie Hospital
Ernākulam, Kerala, India
Meditrina Hospital
Kollam, Kerala, India
Caritas Hospital Trust
Kottayam, Kerala, India
Apollo Rajshree Hospitals
Indore, Madhya Pradesh, India
Rukmani Birla Hospital
Jaipur, Rajasthan, India
Apollo Hospital
Chennai, Tamil Nadu, India
The Madras Medical Mission
Chennai, Tamil Nadu, India
Meenakshi Mission Hospital and Research Center
Madurai, Tamil Nadu, India
Medanta - The Medicity
Gurugramam, India
Krishna Institute of Medical Sciences
Secunderabad, India
University Hospital Galway
Galway, Ireland
Azienda USL Toscana Sud Est
Arezzo, Italy
UOC Cardiologia - Ospedale Maggiore
Bologna, Italy
Azienda Ospedaliero - Universitaria di Ferrara
Ferrara, Italy
Misericordia Hospital
Grosseto, Italy
Fondazione IRCCS Policlinico San Matteo
Pavia, Italy
Azienda USL-IRCCS di Reggio Emilia, Reggio
Reggio Emilia, Italy
Sant Andrea Hospital - Sapienza University
Rome, Italy
AOU Citta Della Salute e della Scienza di Torino
Torino, Italy
OLVG
Amsterdam, Netherlands
Albert Schweitzer Ziekenhuis
Dordrecht, Netherlands
Zuyderland Medisch Centrum
Heerlen, Netherlands
Radboud University Medical Cente
Nijmegen, Netherlands
Sorlandet Hospital Arendal
Kristiansand, Arendal, Norway
Oslo University Hospital Ulleval
Oslo, Norway
Stavanger University Hospital
Stavanger, Norway
Provincial Specialized Hospital
Legnica, Lower Silesian Voivodeship, Poland
Miedziowym Centrum Zdrowia S.A. w Lubinie
Lubin, Lower Silesian Voivodeship, Poland
Medical University of Warsaw
Warsaw, Masovian Voivodeship, Poland
Provincial Specialist Hospital in Wroclaw
Wroclaw, Poland
Tadeusz Marciniak Lower Silesia Specialist Hospital
Wroclaw, Poland
Institute for Cardiovascular Diseases Dedinje
Belgrade, Serbia