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Clinical Study to Evaluate the Possible Efficacy of Metformin in Patients With Parkinson's Disease
Sponsor: Tanta University
Summary
Parkinson's disease (PD) is one of the most common neurodegenerative diseases characterized by the progressive loss of dopaminergic (DA) neurons in the substantia nigra compacta (SNc) and aggregation of Lewy bodies in neurons. Although aging, oxidative damage and neuroinflammation have been recognized to play crucial roles in the pathogenesis of PD, the precise etiology remains obscure. Emerging evidence suggests PD is a systemic metabolic disease, and metabolic abnormality correlates with functional alternations in PD
Key Details
Gender
All
Age Range
50 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2023-06-06
Completion Date
2024-08-20
Last Updated
2026-10-30
Healthy Volunteers
No
Conditions
Interventions
levodopa-carbidopa
levodopa-carbidopa is the standard therapy used in Parkinson's disease
Metformin
Metformin, a biguanide family member commonly used in treatment for type 2 diabetes, appears to increase liver and peripheral tissue sensitivity to insulin as well as reduce hepatic glucose production
Locations (1)
Faculty of Medicine, Menoufia University
Tanta, Shebeen El-Kom, Egypt