Clinical Research Directory
Browse clinical research sites, groups, and studies.
Ischemic Post-conditioning in Acute Ischemic Stroke Thrombectomy (PROTECT-2)
Sponsor: Capital Medical University
Summary
Ischemic post-conditioning is a neuroprotective strategy that has been proven to attenuate reperfusion injury in animal models of stroke. The investigators have conducted a 3 + 3 dose-escalation trial to demonstrate the safety and tolerability of ischemic post-conditioning incrementally for a longer duration of up to 5 min × 4 cycles in stroke patients undergoing mechanical thrombectomy. The purpose of this study is to further determine the efficacy and safety of ischemic post-conditioning in patients with acute ischemic stroke who are treated with mechanical thrombectomy.
Official title: Efficacy and Safety of Ischemic Post-conditioning in Patients With Acute Ischemic Stroke After Mechanical Thrombectomy
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
160
Start Date
2023-11-01
Completion Date
2026-08-16
Last Updated
2026-10-21
Healthy Volunteers
No
Conditions
Interventions
Mechanical thrombectomy combined with ischemic post-conditioning
Ischemic post-conditioning will be applied after successful recanalization of the culprit artery achieve by thrombectomy. Ischemic post-conditioning consists of briefly repeated 4 cycles × 2 minutes of occlusion and reperfusion (equal duration) of the initially occluded artery using a balloon.
Mechanical thrombectomy alone
Successful recanalization was achieved by mechanical thrombectomy without subsequent ischemic post-conditioning.
Locations (6)
Xingtai Central Hospital
Xingtai, Hebei, China
Qinghe People's Hospital
Xingtai, Hebei, China
The First Hospital of Jilin University
Changchun, Jilin, China
The Second Hospital of Tianjin Medical University
Tianjin, Tianjin Municipality, China
Tianjin Huanhu Hospital
Tianjin, Tianjin Municipality, China
Tianjin Fifth Central Hospital
Tianjin, Tianjin Municipality, China