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A Study to Evaluate AZD2693 in Participants Who Are Carriers of the PNPLA3 148M Risk Allele With Non-cirrhotic Non-alcoholic Steatohepatitis With Fibrosis
Sponsor: AstraZeneca
Summary
A Study to Evaluate the Efficacy, Safety and Tolerability of AZD2693 given by subcutaneous injection in adult participants with non-cirrhotic non-alcoholic steatohepatitis with fibrosis and who are carriers of the PNPLA3 148M Risk Allele
Official title: A Randomised, Double-blind, Placebo-controlled, Multi-centre Phase 2b Study to Evaluate the Efficacy, Safety and Tolerability of AZD2693 in Participants With Non-cirrhotic Non-alcoholic Steatohepatitis (NASH) With Fibrosis Who Are Carriers of the PNPLA3 rs738409 148M Risk Allele
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
220
Start Date
2023-03-15
Completion Date
2025-09-29
Last Updated
2026-10-28
Healthy Volunteers
No
Conditions
Interventions
AZD2693
AZD2693 solution SC once per month
Placebo
Sodium chloride 0.9% solution SC once per month
Locations (163)
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Chandler, Arizona, United States
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Peoria, Arizona, United States
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Surprise, Arizona, United States
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Tucson, Arizona, United States
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Tucson, Arizona, United States
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Gardena, California, United States
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La Mesa, California, United States
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Lancaster, California, United States
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Los Angeles, California, United States
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Montclair, California, United States
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Orange, California, United States
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Rialto, California, United States
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Santa Ana, California, United States
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Boca Raton, Florida, United States
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Hialeah, Florida, United States
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Jacksonville, Florida, United States
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Port Orange, Florida, United States
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Winter Park, Florida, United States
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Marietta, Georgia, United States
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Topeka, Kansas, United States
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Detroit, Michigan, United States
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Las Vegas, Nevada, United States
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Westlake, Ohio, United States
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Chickasha, Oklahoma, United States
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Hershey, Pennsylvania, United States
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Summerville, South Carolina, United States
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Cordova, Tennessee, United States
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Austin, Texas, United States
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Brownsville, Texas, United States
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Denison, Texas, United States
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DeSoto, Texas, United States
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Edinburg, Texas, United States
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San Antonio, Texas, United States
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Sugar Land, Texas, United States
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Richmond, Virginia, United States
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Seattle, Washington, United States
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CABA, Argentina
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CABA, Argentina
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Ciudad de Buenos Aires, Argentina
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Córdoba, Argentina
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La Plata, Argentina
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Mar del Plata, Argentina
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San Juan Bautista, Argentina
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Botucatu, Brazil
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Porto Alegre, Brazil
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Porto Alegre, Brazil
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Salvador, Brazil
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São José do Rio Preto, Brazil
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São Paulo, Brazil
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Santiago, Chile
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Santiago, Chile
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Santiago, Chile
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Valdivia, Chile
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Baotou, China
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Beijing, China
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Beijing, China
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Chengdu, China
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Fuzhou, China
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Guangzhou, China
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Hangzhou, China
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Liaocheng, China
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Nanchang, China
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Qingdao, China
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Shanghai, China
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Shanghai, China
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Shanghai, China
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Shenyang, China
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Taiyuan, China
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Wenzhou, China
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Xi'an, China
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Xuzhou, China
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Zhenjiang, China
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Cartagena, Colombia
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Konstanz, Germany
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Magdeburg, Germany
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Mainz, Germany
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Münster, Germany
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Hong Kong, Hong Kong
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Shatin, Hong Kong
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Hyderabad, India
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Jaipur, India
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Jaipur, India
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Punjab, India
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Surat, India
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Milan, Italy
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Palermo, Italy
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Roma, Italy
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Rome, Italy
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Torino, Italy
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Bunkyō City, Japan
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Fukui-shi, Japan
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Fukuoka, Japan
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Gifu, Japan
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Kagoshima, Japan
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Kawasaki-shi, Japan
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Kobe, Japan
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Kumamoto, Japan
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Kure-shi, Japan
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Kurume-shi, Japan
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Kyoto, Japan