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A Study to Evaluate the Long-Term Safety of Astegolimab in Participants With Chronic Obstructive Pulmonary Disease (COPD)
Sponsor: Hoffmann-La Roche
Summary
The purpose of this study is to assess the long-term safety and to explore the efficacy of astegolimab in participants with chronic obstructive pulmonary disease (COPD) who have completed the 52-week placebo-controlled treatment period in parent studies GB43311 or GB44332.
Official title: A Phase III Open-Label Extension Study to Evaluate the Long-Term Safety of Astegolimab in Patients With Chronic Obstructive Pulmonary Disease
Key Details
Gender
All
Age Range
40 Years - 90 Years
Study Type
INTERVENTIONAL
Enrollment
2000
Start Date
2023-06-28
Completion Date
2027-06-30
Last Updated
2026-08-14
Healthy Volunteers
No
Conditions
Interventions
Astegolimab
Participants will receive SC astegolimab Q2W
Locations (481)
UAB Lung Health Center
Birmingham, Alabama, United States
SEC Clinical Research LLC - Dothan 2 - ClinEdge - PPDS
Dothan, Alabama, United States
Jasper Summit Research LLC
Jasper, Alabama, United States
Pulmonary Associates of Mobile PC
Mobile, Alabama, United States
Pulmonary Associates Deer Valley Office
Phoenix, Arizona, United States
AES - DRS - Synexus Clinical Research US, Inc. - Tucson
Tucson, Arizona, United States
Kern Allergy and Medical Research
Bakersfield, California, United States
Cadena Care Institute, LLC
Poway, California, United States
Apex Clinical Research
San Diego, California, United States
St Francis Medical Institute ClinEdge PPDS
Clearwater, Florida, United States
Finlay Medical Research Corporation
Greenacres City, Florida, United States
Flourish Research - Leesburg - PPDS
Leesburg, Florida, United States
Advanced Pulmonary Research Institute
Loxahatchee Groves, Florida, United States
San Marcus Research Clinic Inc.
Miami, Florida, United States
Finlay Medical Research Corporation
Miami, Florida, United States
Oceane7 Medical & Research Center, Inc.
Miami, Florida, United States
Research Institute of South Florida Inc
Miami, Florida, United States
Diverse Clinical Research, LLC
Miami, Florida, United States
Central Florida Pulmonary Group, PA
Orlando, Florida, United States
Florida Institute for Clinical Research, LLC
Orlando, Florida, United States
Flourish Research - Orlando - PPDS
Winter Park, Florida, United States
Pivotal Research Solutions
Stonecrest, Georgia, United States
Northwestern Center for Clinical Research
Chicago, Illinois, United States
ASHA Clinical Research - ClinEdge - PPDS
Hammond, Indiana, United States
Best Clinical Trials
New Orleans, Louisiana, United States
Paul A. Shapero, MD, PA
Bangor, Maine, United States
Exordia Medical Research, Inc.
Fall River, Massachusetts, United States
Pulmonary Research Institute of Southeast Michigan
Farmington Hills, Michigan, United States
Flushing Road Internal Medicine and Pediatrics - F
Flint, Michigan, United States
Revive Research Institute
Southfield, Michigan, United States
Oakland Medical Research Center
Troy, Michigan, United States
The Lung Research Center
Chesterfield, Missouri, United States
Hannibal Regional Healthcare System HRMG Hannibal
Hannibal, Missouri, United States
Midwest Chest Consultants
Saint Charles, Missouri, United States
Washington University School of Medicine in St. Louis
St Louis, Missouri, United States
Midwest Clinical Research LLC
St Louis, Missouri, United States
The Machuca Foundation Inc
Las Vegas, Nevada, United States
Sierra Clinical Research - ClinEdge - PPDS
Las Vegas, Nevada, United States
Renown Regional Medical Center Hospital
Reno, Nevada, United States
AES - DRS - Synexus Clinical Research US, Inc. - New York
New York, New York, United States
American Health Research Inc.
Charlotte, North Carolina, United States
Research Carolina Elite
Denver, North Carolina, United States
Clinical Research of Gastonia
Gastonia, North Carolina, United States
Pulmonix LLC
Greensboro, North Carolina, United States
Carolina Research Center
Shelby, North Carolina, United States
Southeastern Research Center
Winston-Salem, North Carolina, United States
OK Clinical Research
Edmond, Oklahoma, United States
The Oregon Clinic.
Portland, Oregon, United States
Clinical Research Associates Of Central Pa , Llc
DuBois, Pennsylvania, United States
Temple University Hospital
Philadelphia, Pennsylvania, United States
Allergy & Clinical Immun Assoc
Pittsburgh, Pennsylvania, United States
Medtrial, LLC
Columbia, South Carolina, United States
Velocity Clinical Research - Gaffney - PPDS
Gaffney, South Carolina, United States
Lowcountry Lung and Critical Care
North Charleston, South Carolina, United States
Clinical Research of Rock Hill
Rock Hill, South Carolina, United States
ClinSearch, LLC
Chattanooga, Tennessee, United States
Tennessee Comprehensive Lung & Sleep Center
Hendersonville, Tennessee, United States
South Texas Medical Research Institute, Inc., dba TTS Research ? ClinEdge ? PPDS
Boerne, Texas, United States
Corsicana Medical Research
Corsicana, Texas, United States
Trio Clinical Trials
Houston, Texas, United States
Baylor College of Medicine
Houston, Texas, United States
Houston Pulmonary Medicine Associates, PA - Biopharma Informatic, LLC
Houston, Texas, United States
Metroplex Pulmonary and Sleep Medicine Center
McKinney, Texas, United States
Sherman Clinical Research - ClinEdge - PPDS
Sherman, Texas, United States
Vermont Lung Center at the University of Vermont
Colchester, Vermont, United States
University of Virginia Health System
Charlottesville, Virginia, United States
Western Washington Medical Group
Everett, Washington, United States
Allergy Asthma and Sinus Center-Greenfield
Greenfield, Wisconsin, United States
Centro Medico Capital
La Plata, Buenos Aires, Argentina
CEMLO - Centro de Especialidades Médicas Lobos - Patagones 94
Lobos, Buenos Aires, Argentina
Consultorios Medicos Organizacion de Buen Ayre SRL
Buenos Aires, Argentina
Centro de Investigaciones Clínicas Belgrano
Buenos Aires, Argentina
Fundacion Cidea
Buenos Aires, Argentina
Fundacion Faicep
Buenos Aires, Argentina
Instituto de Investigaciones En Alergia Y Enfermedades Respiratorias
Buenos Aires, Argentina
AES - AS - Glenny Corp. S.A. Buenos Aires
Buenos Aires, Argentina
CARE - Centro de Alergia y Enfermedades Respiratorias
CABA, Argentina
Nexo Salud Investigacion Clinica - Riobamba 429
Ciudad Autonoma Buenos Aires, Argentina
CINME S.A. ? Centro de Investigaciones Metabolicas - Rx Trials LLC
Ciudad Autonoma Buenos Aires, Argentina
Centro Médico Dra de Salvo
Ciudad Autonoma Buenos Aires, Argentina
Centro de Medicina Respiratoria
Concepción del Uruguay, Argentina
Sanatorio de la Canada
Córdoba, Argentina
Instituto de Medicina Respiratoria, IMeR
Córdoba, Argentina
Centro Privado de Medicina Respiratoria
Entre Ríos, Argentina
Framingham Centro Medico
La Plata, Argentina
Centro Platense en Investigaciones Respiratorias
La Plata, Argentina
Centro de Investigaciones Medicas Mar Del Plata
Mar del Plata, Argentina
Instituto de Investigaciones Clinicas-Mar del Plata
Mar del Plata, Argentina
Instituto Ave Pulmo
Mar del Plata, Argentina
Centro Medico Dharma
Mendoza, Argentina
Fundacion Scherbovsky
Mendoza, Argentina
INSARES
Mendoza, Mendoza City, Argentina
Centro Respiratorio Quilmes
Quilmes, Argentina
Sala de primeros auxilios Alberto Mignaburu
Ranelagh, Berazategui, Argentina
Instituto Medico de la Fundacion Estudios Clinicos
Rosario, Argentina
Sanatorio Parque de Rosario
Rosario, Argentina
Instituto Medico Fundacion Grupo Colaborativo Rosario Investigacion y Prevencion Medica
Rosario, Argentina
Servicio de Investigacion de Patologias Alergicas-Instituto ABC
Rosario, Argentina
Centro Medico IPAM
Rosario, Argentina
Centro Médico Respire
San Fernando, Argentina