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NCT05882045

PHASE3

A Study of Retatrutide (LY3437943) in Participants With Obesity and Cardiovascular Disease

Sponsor: Eli Lilly and Company

View on ClinicalTrials.gov

Summary

The main purpose of this study is to evaluate the efficacy and safety of retatrutide once weekly in participants with obesity and established cardiovascular disease (CVD). The study will last about 113 weeks.

Official title: A Randomized, Double-Blind, Phase 3 Study to Investigate the Efficacy and Safety of LY3437943 Once Weekly Compared to Placebo in Participants With Severe Obesity and Established Cardiovascular Disease

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

1946

Start Date

2023-05-30

Completion Date

2026-05-14

Last Updated

2026-07-30

Healthy Volunteers

Conditions

Obesity Cardiovascular Diseases

Interventions

DRUG

Retatrutide

Administered SC

DRUG

Placebo

Administered SC

Locations (169)

Central Phoenix Medical Clinic

Phoenix, Arizona, United States

Valley Clinical Trials, Inc.

Covina, California, United States

Neuro-Pain Medical Center

Fresno, California, United States

Valley Research

Fresno, California, United States

Collaborative Neuroscience Research, LLC

Los Alamitos, California, United States

Velocity Clinical Research, Westlake

Los Angeles, California, United States

Valley Clinical Trials, Inc.

Northridge, California, United States

Velocity Clinical Research, Panorama City

Van Nuys, California, United States

Chase Medical Research, LLC

Waterbury, Connecticut, United States

Indago Research & Health Center, Inc

Hialeah, Florida, United States

Clinical Neuroscience Solutions, Inc. dba CNS Healthcare

Jacksonville, Florida, United States

Clinical Neuroscience Solutions, Inc.

Orlando, Florida, United States

Charter Research - Winter Park

Orlando, Florida, United States

Progressive Medical Research

Port Orange, Florida, United States

Pacific Diabetes & Endocrine Center

Honolulu, Hawaii, United States

Elite Clinical Trials

Blackfoot, Idaho, United States

Humphreys Diabetes Center

Boise, Idaho, United States

Northwestern University

Chicago, Illinois, United States

Great Lakes Clinical Trials - Gurnee

Gurnee, Illinois, United States

Central Illinois Diabetes and Clinical Research a Division of Prairie Education and Research Cooperative

Springfield, Illinois, United States

Brengle Family Medicine

Indianapolis, Indiana, United States

Iowa Diabetes and Endocrinology Research Center

West Des Moines, Iowa, United States

Cotton O'Neil Diabetes & Endocrinology

Topeka, Kansas, United States

MedVadis Research Corporation

Waltham, Massachusetts, United States

StudyMetrix Research

City of Saint Peters, Missouri, United States

Las Vegas Medical Research

Las Vegas, Nevada, United States

Palm Research Center Tenaya

Las Vegas, Nevada, United States

IMA Clinical Research Warren

Warren Township, New Jersey, United States

Weill Cornell Medical College

New York, New York, United States

Rochester Clinical Research, LLC

Rochester, New York, United States

Carteret Medical Group

Morehead City, North Carolina, United States

Cleveland Clinic

Cleveland, Ohio, United States

Altoona Center For Clinical Research

Duncansville, Pennsylvania, United States

UPMC Montefiore University Hospital

Pittsburgh, Pennsylvania, United States

Tribe Clinical Research, LLC

Greenville, South Carolina, United States

Trial Management Associates

Myrtle Beach, South Carolina, United States

Tribe Clinical Research - Spartanburg

Spartanburg, South Carolina, United States

Texas Diabetes & Endocrinology, P.A.

Austin, Texas, United States

Pinnacle Clinical Research

Austin, Texas, United States

South Texas Clinical Research

Corpus Christi, Texas, United States

Southern Endocrinology Associates

Mesquite, Texas, United States

Texas Diabetes & Endocrinology, P.A.

Round Rock, Texas, United States

Sleep Therapy Research Center

San Antonio, Texas, United States

Consano Clinical Research, LLC

Shavano Park, Texas, United States

Advanced Research Institute

Ogden, Utah, United States

Rainier Clinical Research Center

Renton, Washington, United States

Fundación Respirar

Buenos Aires, Buenos Aires, Argentina

CEDIC

CABA, Buenos Aires, Argentina

Centro de Investigaciones Metabólicas (CINME)

Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina

IDIM - Instituto de Investigaciones Metabólicas

Ciudad de Buenos Aires, Buenos Aires, Argentina

MICA - Medicina e Investigación Cardiometabólica

Del Viso, Buenos Aires, Argentina

Instituto de Investigaciones Clínicas Mar del Plata

Mar del Plata, Buenos Aires, Argentina

DIM Clínica Privada

Ramos Mejía, Buenos Aires, Argentina

Consultorio de Investigación Clínica EMO SRL