Clinical Research Directory

Browse clinical research sites, groups, and studies.

Sites Groups Studies

Back to Studies

RECRUITING

NCT05895786

PHASE3

A Study to Understand How the Study Medicine (PF-06823859) Works in People With Active Idiopathic Inflammatory Myopathies [Dermatomyositis (DM) and Polymyositis (PM)]

Sponsor: Pfizer

View on ClinicalTrials.gov

Summary

The purpose of the study is to understand how the study medicine PF-06823859 (dazukibart) works in people with idiopathic inflammatory myopathies (DM and PM). These disorders cause inflammation that weakens the muscles that are important for movement and may also cause skin rash in people with DM. This study is seeking participants who: * Are 18 years of age or older or minimum legal adult age as defined per local regulation, whichever is greater * Have active DM or active PM. * Are receiving a stable dose of 1 corticosteroid taken by mouth and/or 1 traditional immunosuppressant. * Note: Corticosteroids and immunosuppressants are medicines that help reduce inflammation and may signal to the immune system not to attack the body. Dermatomyositis (DM) is a rare disease that causes muscle inflammation that results in muscle weakness and low muscle stamina. Patients with DM have a characteristic skin rash. Polymyositis (PM) is a rare disease that involves mainly muscle inflammation resulting in muscle weakness, that can sometimes be painful. Patients with DM and PM may have trouble going up the steps, walking or getting to a standing position. Some of the participants will receive the study medicine (dazukibart) and some will receive placebo (which is similar to study medicine but contains no medicine in it). The study medicine or placebo will be given as an intravenous (IV) infusion (directly into the veins), which takes about 1 hour; every 4 weeks from Day 1 to Week 48 of the study. Both dazukibart and placebo and will be given at the study site. The study will compare the experiences of people receiving study medication to those of the people who do not. This will help to see if dazukibart is safe and effective. Participants will take part in this study for about 13 months. During this time, participants will have 15 study visits. These visits will be performed at the study site.

Official title: A PHASE 3, MULTICENTER, DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED STUDY TO EVALUATE THE EFFICACY AND SAFETY OF PF-06823859 IN PARTICIPANTS WITH ACTIVE IDIOPATHIC INFLAMMATORY MYOPATHIES (INCLUDING PARTICIPANTS WITH ACTIVE DERMATOMYOSITIS OR POLYMYOSITIS)

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

318

Start Date

2023-05-20

Completion Date

2030-07-29

Last Updated

2026-09-15

Healthy Volunteers

Conditions

Myositis

Interventions

DRUG

PF-06823859

anti-interferon beta therapy

DRUG

Placebo

Placebo for PF-06823859

Inclusion Criteria: * Male or female adults (≥18 years old or minimum legal adult age as defined per local regulation, whichever is greater) * Active dermatomyositis (DM) or polymyositis (PM) with age of onset * 18 years old. * Must be receiving a stable dose of standard of care (SOC) background medications at the time of enrollment. Exclusion Criteria: * Myositis due to non-Idiopathic inflammatory myopathies (non-IIM) * Existing diagnosis of inclusion body myositis (IBM) * Presence of immune-mediated necrotizing myositis (IMNM) * Myositis with end-stage organ involvement * Active bacterial, viral or fungal infections or hospitalizations for serious infections within 60 days prior to enrollment * History of recurrent bacterial, viral, fungal, mycobacterial or other infections * Clinically significant finding on a chest x-ray * Have cancer or a history of cancer within 5 years of screening * Significant current or prior disease conditions that may interfere with the response to or safety of the study medicine, including but not limited to: * history of major organ transplant * acute coronary syndrome or any history of significant cerebrovascular disease within 24 weeks of screening * preexisting demyelinating disorder such as multiple sclerosis, or other severe neurological disorder * major surgery within 4 weeks of screening, or scheduled to occur during the study, excluding diagnostic surgery * previous treatment with total lymphoid irradiation * history of any lymphoproliferative disorder such as Epstein Barr Virus, history of lymphoma, leukemia, or symptoms of current lymphatic or lymphoid disease * Clinically significant depression, suicidal ideation, or previous history of suicidal behaviors * Other medical or laboratory abnormality that may increase the risk of study participation * Previous administration with an investigational product (drug or vaccine) within 30 days or of the first dose of study medicine * Current use or incomplete appropriate washout period of any prohibited medication(s) or known exposure to anti-interferon beta (PF-06823859) or any type of anti-interferon beta therapy * Prior SOC medication that does not fulfill the criteria * Certain laboratory results from screening assessments that may interfere with study participation. * Investigator site staff directly involved in the conduct of the study and their family members, site staff and sponsor and sponsor delegate employees directly involved in the conduct of the study and their family members

Locations (138)

Arizona Arthritis & Rheumatology Research, PLLC

Glendale, Arizona, United States

Neuromuscular Research Center

Phoenix, Arizona, United States

Mayo Clinic Hospital

Phoenix, Arizona, United States

Mayo Clinic in Arizona - Scottsdale

Scottsdale, Arizona, United States

200 UCLA Medical Plaza

Los Angeles, California, United States

UCLA Clinical & Translational Research Center (CTRC)

Los Angeles, California, United States

UCLA

Los Angeles, California, United States

Center for Clinical Research - Chapman Pavilion

Orange, California, United States

UCI Douglas Hospital

Orange, California, United States

UCI Health Center for Innovative Health Therapies

Orange, California, United States

University of California - Irvine

Orange, California, United States

Samir Macwan, M.D., Inc.

Rancho Mirage, California, United States

Mayo Clinic in Florida

Jacksonville, Florida, United States

Lal Bhagchandani, M.D

Margate, Florida, United States

University of Miami

Miami, Florida, United States

University of Miami Dermatology Clinical Trials Unit

Miami, Florida, United States

University of Miami

Miami, Florida, United States

Unviversity of Miami

Miami, Florida, United States

Omega Research Orlando

Orlando, Florida, United States

IRIS Research and Development, LLC

Plantation, Florida, United States

West Broward Pulmonary Consultants

Plantation, Florida, United States

West Broward Rheumatology Associates

Tamarac, Florida, United States

Brigham and Women's Hospital

Boston, Massachusetts, United States

CTC - Brigham & Women's Hospital

Boston, Massachusetts, United States

CTH - Brigham & Women's Hospital

Boston, Massachusetts, United States

Washington University Pulmonary Function Laboratory

St Louis, Missouri, United States

Washington University School of Medicine

St Louis, Missouri, United States

NYU Langone Health - Clinical and Translational Science Institute Research Pharmacy