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Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients
Sponsor: Summit Therapeutics
Summary
This is a Phase 3 Randomized, double-blind, Multiregional Study of Ivonescimab Combined with Chemotherapy Versus Pembrolizumab Combined with Chemotherapy for the First-line Treatment of Metastatic Non-small Cell Lung Cancer. The primary endpoint is overall survival and progression free survival assessed by investigator. The key secondary endpoints include response and safety.
Official title: A Randomized, Double-blind, Multiregional Phase 3 Study of Ivonescimab Combined With Chemotherapy Versus Pembrolizumab Combined With Chemotherapy for the First-line Treatment of Metastatic Non-small Cell Lung Cancer (HARMONi-3)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
1600
Start Date
2023-10-26
Completion Date
2029-12-31
Last Updated
2026-10-08
Healthy Volunteers
No
Conditions
Interventions
Ivonescimab Injection
Subject will receive ivonescimab and chemotherapy as an IV injection
Pembrolizumab Injection
Subject will receive pembrolizumab and chemotherapy as an IV injection
Locations (260)
Banner University Medical Center
Phoenix, Arizona, United States
TMC Healthcare
Tucson, Arizona, United States
Genesis Cancer and Blood Institute
Hot Springs, Arkansas, United States
University of Arkansas
Little Rock, Arkansas, United States
LA Cancer Network
Anaheim, California, United States
The Oncology Institute of Hope & Innovation
Cerritos, California, United States
University of Southern California (USC)
Los Angeles, California, United States
Cedar Sinai Medical Center
Los Angeles, California, United States
Valkyrie Clinical Trials
Los Angeles, California, United States
Sutter Institute for Medical Research
Sacramento, California, United States
UC Davis Medical Center
Sacramento, California, United States
University of California Los Angeles (UCLA)
Santa Monica, California, United States
Providence Medical Foundation
Santa Rosa, California, United States
Kaiser Permanente
Vallejo, California, United States
Rocky Mountain Cancer
Lone Tree, Colorado, United States
Banner MD Anderson Cancer Center at North Colorado Medical Center
Loveland, Colorado, United States
Hartford Hospital
Hartford, Connecticut, United States
Yale University
New Haven, Connecticut, United States
Florida Cancer Specialists & Research Institute (FCS)-East
Fort Myers, Florida, United States
BioResearch Partner- Hialeah Hospital
Hialeah, Florida, United States
Memorial Healthcare System
Hollywood, Florida, United States
Mayo Clinic
Jacksonville, Florida, United States
Cancer Specialists of North Florida
Jacksonville, Florida, United States
Ocala Oncology
Ocala, Florida, United States
Cancer Care of Brevard
Palm Bay, Florida, United States
Ascension Sacred Heart Health System
Pensacola, Florida, United States
Exigent Network
Petersburg, Florida, United States
BRCR Medical Center Inc
Plantation, Florida, United States
Florida Cancer Specialists & Research Institute (FCS) - North
St. Petersburg, Florida, United States
BRCR Medical Center Inc.
Tamarac, Florida, United States
Florida Cancer Specialists & Research Institute (FCS)-South
West Palm Beach, Florida, United States
Central Georgia Cancer Care
Macon, Georgia, United States
Northwestern Memorial Hospital
Chicago, Illinois, United States
Illinois Cancer Care P.C.
Peoria, Illinois, United States
University of Kansas Cancer Center
Westwood, Kansas, United States
Baptist Health
Lexington, Kentucky, United States
Sidney Kimmel Comprehensive Cancer Center
Baltimore, Maryland, United States
Ascension Saint Agnes Hospital
Baltimore, Maryland, United States
Lahey Hospital
Burlington, Massachusetts, United States
University of Michigan
Ann Arbor, Michigan, United States
Trinity Health
Ann Arbor, Michigan, United States
Karmanos Cancer Insitute
Detroit, Michigan, United States
Henry Ford Hospital
Detroit, Michigan, United States
Mayo Clinic
Rochester, Minnesota, United States
Park Nicollet Institute
Saint Paul, Minnesota, United States
American Oncology Partners, PA
Kansas City, Missouri, United States
Washington University St.Louis
St Louis, Missouri, United States
St. Vincent Cancer Center
Billings, Montana, United States
University of Nebraska Medical Center (UNMC)
Omaha, Nebraska, United States
Dartmouth-Hitchcock Medical Center
Lebanon, New Hampshire, United States
Mount Sinai
New York, New York, United States
Memorial Sloan Kettering
New York, New York, United States
SUNY Upstate Medical University
Syracuse, New York, United States
University of North Carolina
Chapel Hill, North Carolina, United States
Levine Center
Charlotte, North Carolina, United States
Oncology Hematology Care (OHC), Inc
Cincinnati, Ohio, United States
University Hospitals Case Medical Center
Cleveland, Ohio, United States
Cleveland Clinic
Cleveland, Ohio, United States
Willamette Valley Cancer Institute and Research Center (WVCI)
Eugene, Oregon, United States
Medical University of South Carolina (MUSC)
Charleston, South Carolina, United States
Prisma Health-Upstate
Greenville, South Carolina, United States
West Cancer Center
Memphis, Tennessee, United States
SCRI-Nashville
Nashville, Tennessee, United States
Texas Oncology- Austin
Austin, Texas, United States
Texas Oncology-Dallas
Dallas, Texas, United States
UT Southwestern Medical Center
Dallas, Texas, United States
Houston Methodist Hospital
Houston, Texas, United States
MD Anderson Cancer Center
Houston, Texas, United States
Texas Oncology-San Antonio
San Antonio, Texas, United States
Texas Oncology-Tyler
Tyler, Texas, United States
University of Texas at Tyler
Tyler, Texas, United States
Virginia Oncology Associates
Norfolk, Virginia, United States
Virginia Cancer
Reston, Virginia, United States
Swedish Cancer Institute
Seattle, Washington, United States
Cancer Care NW Centers
Spokane, Washington, United States
Carbone Cancer Center
Madison, Wisconsin, United States
az Glorieux
Ronse, Belgium
CHU UC Louvain Namur
Yvoir, Belgium
London Regional (LRCP)
London, Ontario, Canada
Ottawa Cancer Center
Ottawa, Ontario, Canada
Saskatchewan Cancer
Regina, Saskatchewan, Canada
Fu Yang People's Hospital
Yangzhou, Anhui, China
Beijing Chest Hospital
Tongzhou, Beijing Municipality, China
Fujian Cancer Hospital
Fuzhou, Fujian, China
Gansu Provincial Cancer Hospital
Lanzhou, Gansu, China
Fujian Cancer Hospital
Guangzhou, Guangdong, China
The First Affiliated Hospital of Guangxi Medical University
Nanning, Guangxi, China
Hainan General Hospital
Haikou, Hainan, China
The Fourth Hospital of Hebei Medical University
Shijiazhuang, Hebei, China
Harbin Medical University Cancer Hospital
Harbin, Heilongjiang, China
Henan University of Science and Technology Affiliated Anyang Cancer Hospital
Anyang, Henan, China
Nanyang Central Hospital
Nanyang, Henan, China
Henan Cancer Hospital
Zhengzhou, Henan, China
The First Affiliated Hospital of Yangtze University
Jingzhou, Hubei, China
Xiangyang Central Hospital
Xiangyang, Hubei, China
Xiangya Hospital of Central South University
Changsha, Hunan, China
Hunan Cancer Hospital Thoracic Medicine 1
Changsha, Hunan, China
The First Affiliated Hospital Of University Of South China
Hengyang, Hunan, China
The Affiliated Hospital of Xuzhou Medical University
Xuzhou, Jiangsu, China
The Affiliated Hospital of Xuzhou Medical University
Xuzhou, Jiangsu, China