Clinical Research Directory
Browse clinical research sites, groups, and studies.
Study to Assess Speed of Onset and Durability of Effectiveness of Upadacitinib in Adult Participants With Moderate to Severe Crohn's Disease (CD) in Real World Clinical Practice.
Sponsor: AbbVie
Summary
Crohn's disease (CD) is an incurable chronic inflammatory disorder of the gastrointestinal tract. This study will assess how safe and effective upadacitinib is in treating moderately to severely active CD in real world. Speed of onset and durability of effectiveness will be assessed. Upadacitinib is a drug approved for the treatment of CD. All study participants will receive upadacitinib as prescribed by their study doctor in accordance with approved local label. Approximately 1200 participants will be enrolled in approximately 230 sites across the world. Participants will receive upadacitinib as prescribed by their physician according to their routine clinical practice and local label. Participants will be followed for up to 3 years. There is expected to be no additional burden for participants in this trial. Study visits may be conducted on-site or virtually as per standard of care.
Official title: A Multi-country, Prospective, Post-marketing Study of UPadacitinib Evaluating Speed of Onset and Durability of Effectiveness for Patients With Moderate to Severe Crohn's Disease for 3 Years in Real-world Clinical Practice (UPlift)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
1200
Start Date
2024-02-19
Completion Date
2028-09
Last Updated
2025-07-17
Healthy Volunteers
No
Conditions
Locations (180)
Blacktown Hospital /ID# 258574
Blacktown, New South Wales, Australia
Macquarie University Hospital /ID# 268722
Macquarie University, New South Wales, Australia
Mater Misericordiae Limited /ID# 258535
South Brisbane, Queensland, Australia
Ibd Sa /Id# 268335
Kurralta Park, South Australia, Australia
The Queen Elizabeth Hospital /ID# 258536
Woodville South, South Australia, Australia
Monash Health - Monash Medical Centre /ID# 258538
Clayton, Victoria, Australia
The Alfred Hospital /ID# 258537
Melbourne, Victoria, Australia
Gastro Med EOOD /ID# 267777
Pazardzhik, Plovdiv, Bulgaria
ET dr Nikolay Tsonev /ID# 267584
Samokov, Sofia, Bulgaria
MC Higia HB /ID# 267575
Sofiya, Sofia, Bulgaria
Umbal Kaspela /ID# 267562
Plovdiv, Bulgaria
Diagnostic consultative center Focus-5 /ID# 267576
Sofia, Bulgaria
Diagnostic consultative center Focus-5 /ID# 268600
Sofia, Bulgaria
AIPSMP dr Mirchev EOOD /ID# 267583
Varna, Bulgaria
MC Nadejda Femily EOOD /ID# 267585
Varna, Bulgaria
DCC Mladost M /ID# 267586
Varna, Bulgaria
Foothills Medical Centre /ID# 263475
Calgary, Alberta, Canada
Dr. J Siffledeen Profess Pract /ID# 262713
Edmonton, Alberta, Canada
Fraser Clinical Trials Inc /ID# 262347
New Westminster, British Columbia, Canada
University of Manitoba & Shared Health /ID# 265853
Winnipeg, Manitoba, Canada
Queen Elizabeth II Health Sciences Centre - Victoria General /ID# 262764
Halifax, Nova Scotia, Canada
Barrie GI Associates /ID# 268436
Barrie, Ontario, Canada
London Health Sciences Center- University Hospital /ID# 262693
London, Ontario, Canada
West GTA Endoscopy /ID# 262946
Mississauga, Ontario, Canada
Scott Shulman Medicine Professional Corporation /ID# 262060
North Bay, Ontario, Canada
Toronto Immune and Digestive Health Institute Inc /ID# 262540
North York, Ontario, Canada
ABP Research Services Corp. /ID# 263111
Oakville, Ontario, Canada
Toronto Digestive Disease Associates /ID# 262050
Vaughan, Ontario, Canada
Universite de Montreal - Hopital Maisonneuve-Rosemont /ID# 266264
Montreal, Quebec, Canada
Disc_Royal Victoria Hospital / McGill University Health Centre /ID# 262692
Montreal, Quebec, Canada
Diex Recherche Quebec Inc. /ID# 268256
Québec, Canada
Peking Union Medical College Hospital (East) - Dongdan Campus /ID# 265873
Beijing, Beijing Municipality, China
Chongqing General Hospital /ID# 268384
Chongqing, Chongqing Municipality, China
The First Affiliated Hospital, Sun-Yat Sen University /ID# 264189
Guangzhou, Guangdong, China
The Sixth Affiliated Hospital of Sun Yat-sen University /ID# 265673
Guangzhou, Guangdong, China
Nanjing Drum Tower Hospital /ID# 266205
Nanjing, Jiangsu, China
Ruijin Hospital /ID# 266869
Shanghai, Shanghai Municipality, China
West China Hospital of Sichuan University /ID# 265674
Chengdu, Sichuan, China
Sichuan Provincial People's Hospital /ID# 270703
Chengdu, Sichuan, China
Jinhua Central Hospital /ID# 265871
Jinhua, Zhejiang, China
Fakultní Nemocnice Brno - Jihlavská /ID# 268351
Brno, Brno-mesto, Czechia
SurGal Clinic /ID# 268757
Brno, South Moravian, Czechia
Nemocnice Ceske Budejovice /ID# 264492
České Budějovice, Czechia
Herlev Hospital /ID# 262487
Herlev, Capital Region, Denmark
Hvidovre Hospital /ID# 262613
Hvidovre, Capital Region, Denmark
West Tallinn Central Hospital /ID# 270144
Tallinn, Harju, Estonia
East Tallinn Central Hospital - Magdaleena Unit /ID# 266653
Tallinn, Harju, Estonia
Tartu University Hospital /ID# 270148
Tartu, Tartu, Estonia
Chu de Nice-Hopital L'Archet Ii /Id# 261060
Nice, Alpes-Maritimes, France
CHU Clermont-Ferrand /ID# 259294
Clermont, Auvergne-Rhône-Alpes, France
Hopital Edouard Herriot /ID# 266844
Lyon, Auvergne-Rhône-Alpes, France
APHM - Hopital Nord /ID# 259304
Marseille, Bouches-du-Rhone, France
Chu Dijon /Id# 265910
Dijon, Bourgogne-Franche-Comté, France
Centre Hospitalier Universitaire de Bordeaux /ID# 259298
Pessac, Gironde, France
CHU Toulouse - Hopital Rangueil /ID# 258636
Toulouse, Haute-Garonne, France
Clinique Beau Soleil /ID# 259289
Montpellier, Herault, France
CHU de Montpellier - Hopital Saint Eloi /ID# 269938
Montpellier, Herault, France
Ch Chalons En Champagne /Id# 259344
Châlons-en-Champagne, Marne, France
CHRU Lille - Hopital Claude Huriez /ID# 259302
Lille, Nord, France
Cabinet du docteur Médina Boualit /ID# 259291
Saint-Amand-les-Eaux, Nord, France
AP-HP - Hopital Bicetre /ID# 259118
Le Kremlin-Bicêtre, Paris, France
CHU de Nantes, Hotel Dieu -HME /ID# 259293
Nantes, Pays de la Loire Region, France
Centre Hospitalier Universitaire de Saint Etienne - Hopital Nord /ID# 259303
St-Priest-en-Jarez, Pays de la Loire Region, France
Centre Hospitalier de la Cote Basque /ID# 259297
Bayonne, Pyrenees-Atlantiques, France
GH Mutualiste Les Portes Du Sud /ID# 259299
Vénissieux, Rhone, France
Hôpital Nord Ouest - Villefranche-sur-Saône /ID# 266999
Villefranche-sur-Saône, Rhone, France
CHU Amiens-Picardie Site Sud /ID# 259121
Amiens, Somme, France
Pole Sante Saint-Jean /ID# 259296
Cagnes-sur-Mer, France
Centre Hospitalier de CHOLET /ID# 259288
Cholet, France
CH DREUX - Hopital Victor Jousselin /ID# 258635
Dreux, France
AP-HP - Hopital Saint-Antoine /ID# 259116
Paris, France
CHRU Pontchaillou /ID# 259347
Rennes, France
CHU de Strasbourg /ID# 259343
Strasbourg, France
Hopital Beaujon /ID# 259287
Clichy, Île-de-France Region, France
Centre Medico Chirurgical Ambroise Pare Hartmann /ID# 259339
Neuilly-sur-Seine, Île-de-France Region, France
Medizinisches Versorgungszentrum Dachau /ID# 273294
Dachau, Bavaria, Germany
Klinikum Lueneburg /ID# 256107
Lüneburg, Lower Saxony, Germany
Verein für Wissenschaft und Forschung /ID# 265880
Oldenburg, Lower Saxony, Germany
Dres. Kamp & Partner /ID# 267560
Minden, North Rhine-Westphalia, Germany
Praxis S. Tetzlaff /ID# 264613
Buedelsdorf, Schleswig-Holstein, Germany
Praxis fuer Gastroenterologie /ID# 256106
Lübeck, Schleswig-Holstein, Germany
Universitaetsklinikum Jena /ID# 273284
Jena, Thuringia, Germany
Charite Universitaetsmedizin Berlin - Campus Mitte /ID# 264097
Berlin, Germany
Gastro Studien GbR /ID# 264617
Berlin, Germany
Krankenhaus Waldfriede /ID# 264616
Berlin, Germany
Dr. Janschek /ID# 273218
Dresden, Germany
SKH Studien GmbH /ID# 256100
Hamburg, Germany
Private Practice - Dr. Matthias Eichler /ID# 256105
Hamburg, Germany
Medizinische Hochschule Hannover /ID# 256109
Hanover, Germany
GSGH Gastroenterologische Studiengesellschaft Herne GbR /ID# 268434
Herne, Germany
Gastropraxis Magdeburg /ID# 266789
Magdeburg, Germany
Praxis Dres Brendel /ID# 256103
Nuremberg, Germany
Praxis Dr. Kempelmann /ID# 256110
Tostedt, Germany
Evangelismos Hospital /ID# 268132
Athens, Attica, Greece
General Hospital of Athens G. Gennimatas /ID# 271501
Athens, Attica, Greece
General Hospital of Athens Ippokratio /ID# 270248
Athens, Attica, Greece
General Hospital of Athens Laiko /ID# 266262
Athens, Attica, Greece
University General Hospital of Heraklion /ID# 266260
Heraklion, Crete, Greece
University General Hospital of Alexandroupoli /ID# 270161
Alexandroupoli, Evros, Greece
Sotiria Thoracic Diseases Hospital of Athens /ID# 264352
Athens, Greece