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DESTINY Breast Respond HER2-(Ultra)Low Europe
Sponsor: Daiichi Sankyo Europe, GmbH, a Daiichi Sankyo Company
Summary
Trastuzumab deruxtecan (T-DXd) as monotherapy is indicated for the treatment of adult patients with unresectable or metastatic HER2-low breast cancer who have received prior chemotherapy in the metastatic setting or developed disease recurrence during or within 6 months of completing adjuvant chemotherapy. Based on the extended therapeutic indication of Trastuzumab deruxtecan (Enhertu®), a new patient population will be enrolled, comprising adult patients with unresectable or metastatic HR-positive, HER2-low, or HER2-(ultra)low breast cancer who have received at least one endocrine therapy in the metastatic setting and are not considered suitable for endocrine therapy as the next line of treatment.
Official title: A Prospective, Non-interventional Study (NIS) With Trastuzumab Deruxtecan For Patients With HER2-(Ultra)Low Expressing Unresectable and/or Metastatic Breast Cancer Accompanied By a Disease Registry of Patients Treated With Conventional Chemotherapy (DESTINY Breast Respond HER2-(Ultra)Low Europe)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
2295
Start Date
2023-10-24
Completion Date
2030-12-31
Last Updated
2026-08-19
Healthy Volunteers
No
Conditions
Interventions
Trastuzumab deruxtecan
This is a non-interventional study and medication will be administered according to the SmPC as local standard of care and as part of the routine clinical practice. Trastuzumab (T-DXd) to be administered according to the SmPC. Conventional therapy (eg. capecitabine, eribulin, gemcitabine, paclitaxel, nab paclitaxel) to be administered according to the SmPC.
Locations (216)
Medizinische Universität Graz
Graz, Austria
Medizinische Universität Graz
Graz, Austria
Medizinische Universität Innsbruck
Innsbruck, Austria
Klinikum Klagenfurt am Wörthersee
Klagenfurt, Austria
LKH Hochsteiermark-Leoben
Leoben, Austria
Ordensklinikum Linz GmbH Barmherzige Schwestern
Linz, Austria
Interne II, LKH Feldkirch
Rankweil, Austria
KH der Barmherzigen Brüder Salzburg
Salzburg, Austria
Uniklinikum Salzburg
Salzburg, Austria
Medical University of Vienna
Vienna, Austria
Medizinische Universität Wien
Vienna, Austria
Krankenhaus Hietzing
Vienna, Austria
Salzkammergut Klinikum Vöcklabruck
Vöcklabruck, Austria
Klinikum Wels-Grieskirchen GmbH
Wels, Austria
Landesklinikum Wiener Neustadt
Wiener Neustadt, Austria
ASZ Aalst
Aalst, Belgium
Chirec Delta Hospital
Auderghem, Belgium
Imeldaziekenhuis Bonheiden
Bonheiden, Belgium
AZ Klina
Brasschaat, Belgium
AZ Sint-Jan Brugge av
Bruges, Belgium
CHU Brugmann
Brussels, Belgium
Cliniques universitaires Saint-Luc
Brussels, Belgium
Chu Helora- Hôpital de La Louvière- site Jolimont
Haine-Saint-Paul, Belgium
Jessa Ziekenhuis
Hasselt, Belgium
CHU Tivoli
La Louvière, Belgium
CHC MontLegia
Liège, Belgium
Hôpital de la Citadelle
Liège, Belgium
CHU UCL Namur/Site Sainte Elisabeth
Namur, Belgium
Clinique Saint Pierre Ottignies
Ottignies, Belgium
VITAZ
Sint-Niklaas, Belgium
CHR Verviers East Belgium
Verviers, Belgium
Aalborg Universitetshospital, Syd
Aalborg, Denmark
Aarhus University Hospital
Aarhus N, Denmark
Herlev Hospital
Herlev, Denmark
Onkologisk og Palliativ afdeling, Nordsjællands Hospital
Hillerød, Denmark
Naestved Hospital
Næstved, Denmark
Sygehus Sønderjylland, Sønderborg
Sønderborg, Denmark
CHU Amiens Picardie
Amiens, France
Clinique de l'Europe
Amiens, France
Hôpital Privé d'Antony
Antony, France
Hôpital Privé les Bonnettes
Arras, France
Institut du Cancer Avignon Provence
Avignon, France
CH Cote Basque
Bayonne, France
Clinique Belharra
Bayonne, France
Chu Jean Minjoz Besancon
Besançon, France
Clinique Tivoli-Ducos
Bordeaux, France
Centre hospitalier Fleyriat
Bourg-en-Bresse, France
Centre Francois Baclesse
Caen, France
Centre Hospitalier William Morey
Chalon-sur-Saône, France
CH Metropole Savoie
Chambéry, France
Pole Sante Leonard De Vinci
Chambray-lès-Tours, France
CH Cholet
Cholet, France
Centre Jean Perrin
Clermont-Ferrand, France
Polyclinique St Côme
Compiègne, France
Hôpital Henri Mondor
Créteil, France
Centre Léonard de Vinci
Dechy, France
Centre Georges Francois Leclerc
Dijon, France
CHU Martinique
Fort de France Cedex, France
CHI Frejus Saint Raphael
Fréjus, France
Groupe Hospitalier Mutualiste (GHM) de Grenoble - Institut Daniel Hollard (IDH)
Grenoble, France
Polyclinique De Blois
La Chaussée-Saint-Victor, France
La Tronche - CHU Grenoble
La Tronche, France
Centre de cancerologie de la Sarthe
Le Mans, France
Centre Hospitalier Emile Roux
Le Puy-en-Velay, France
Hôpital Franco-Britannique Cognac Jay
Levallois-Perret, France
Centre Oscar Lambret
Lille, France
CHU Lille
Lille, France
Hôpital Prive Le Bois
Lille, France
CHU de Limoges
Limoges, France
Hospices Civils De Lyon
Lyon, France
Hôpital Jean Mermoz
Lyon, France
Hôpital-Clinique Claude Bernard
Metz, France
GH Havre
Montivilliers, France
Clinique Clementville
Montpellier, France
Groupe Hospitalier privé Ambroise Pare Hartmann
Neuilly-sur-Seine, France
Hopital Americain de Paris
Neuilly-sur-Seine, France
Centre Antoine Lacassagne
Nice, France
Centre Hospitalier de Niort
Niort, France
Centre Médical ONCOGARD
Nîmes, France
Institut Curie
Paris, France
Groupement Hospitalier Diaconesses Croix Saint Simon
Paris, France
Hopital Europeen Georges Pompidou
Paris, France
Hôpital Saint Joseph
Paris, France
Centre Hospitalier de Pau
Pau, France
CHU Poitiers
Poitiers, France
Institut Godinot
Reims, France
Polyclinique Courlancy
Reims, France
Centre Eugene Marquis
Rennes, France
Clinique Saint Hilaire
Rouen, France
Clinique Mathilde
Rouen, France
Saint Cloud -Rene Huguenin Institut Curie
Saint-Cloud, France
CHU Réunion Site Sud
Saint-Paul, France
Institut De Cancerologie Paris Nord
Sarcelles, France
Centre Hospitalier de Sens
Sens Cédex, France
Hôpital Foch
Suresnes, France
CHR Metz Thionville
Thionville, France
HIA Sainte-Anne
Toulon, France
Centre Hospitalier de Troyes
Troyes, France
Hopital Prive Drome Ardeche
Valence, France
Nouvelle Clinique Des Dentellières
Valenciennes, France